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| 1 | Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells显示文摘人的导致的 pluripotent 茎(iPS ) 房间类似于胚胎的茎(ES ) 房间,和罐头强烈地增殖并且区分进许多房间类型。然而,人的 iPS 房间的肝的区别还没被报导了。在这份报告,人的 iPS 房间被导致由一个逐步的协议区分进肝的房间。肝房间标记的表达式和人的 iPS 的肝相关的函数导出房间的房间被监视并且与区分的人的 ES 房间和主要人的 hepatocytes 的相比。在白天 7 点的约 60% 区分的人的 iPS 房间表示了肝的标记 alpha fetoprotein 和白长袍的。在白天 21 点的区分的房间包括白朊 Asecretion,肝糖合成,脲生产和可诱导的细胞色素 P450 活动展出了肝房间功能。肝的标记的表示和 iPS 的肝相关的功能导出房间的肝的房间比得上人的 ES 导出房间的肝的房间的。这些结果证明人的 iPS 房间,类似于人的 ES 房间,能高效地被导致区分房间进象 hepatocyte 一样。 | Zhihua Song Jun Cai Yanxia Liu Dongxin Zhao Jun Yong Shuguang Duo Xijun Song Yushan Guo Yang Zhao Han Qin Xiaolei Yin Chen Wu Jie Che Shichun Lu Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，11： | 63 |
| 2 | Magmatism during continental collision, subduction, exhumation and mountain collapse in collisional orogenic belts and continental net growth: A perspective显示文摘Continental orogens on Earth can be classified into accretionary orogen and collisional orogen.Magmatism in orogens occurs in every periods of an orogenic cycle,from oceanic subduction,continental collision to orogenic collapse.Continental collision requires the existence of prior oceanic subduction zone.It is generally assumed that the prerequisite of continental deep subduction is oceanic subduction and its drag force to the connecting passive-margin continental lithosphere during continental collision.Continental subduction and collision lead to the thickening and uplift of crust,but the formation time of the related magmatism in orogens depends on the heating mechanism of lithosphere.The accretionary orogens,on the other hand,have no strong continental collision,deep subduction,no large scale of crustal thrusting,thickening and uplift,and no UHP eclogite-facies metamorphic rocks related to continental deep subduction.Even though arc crust could be significantly thickened during oceanic subduction,it is still doubtful that syn-or post-collisional magmatism would be generated.In collisional orogens,due to continental deep subduction and significant crustal thickening,the UHP metamorphosed oceanic and continental crusts will experience decompression melting during exhumation,generating syn-collisional magmatism.During the orogen unrooting and collapse,post-collisional magmatism develops in response to lithosphere extension and upwelling of asthenospheric mantle,marking the end of an orogenic cycle.Therefore,magmatism in orogens can occur during the continental deep subduction,exhumation and uplift after detachment of subducted oceanic crust from continental crust,and extensional collapse.The time span from continental collision to collapse and erosion of orogens(the end of orogenic cycle)is 50–85 Myr.Collisional orogens are the key sites for understanding continental deep subduction,exhumation,uplift and orogenic collapse.Magmatism in collisional orogens plays important roles in continental reworking and net growth. | SONG ShuGuang WANG MengJue WANG Cao NIU YaoLing | 2015 | Science China Earth Sciences2015，58，8： | 39 |
| 3 | Early Paleozoic granite in Nujiang River of northwest Yunnan in southwestern China and its tectonic implications显示文摘沿着在西方的云南的中国缅甸边阶的 Nujiang 区域收到了很多注意并且被认为是西藏的高原的向东南的逃跑的重要隧道。这条隧道被红 River-Ailao 山左文字的 strick 滑倒差错在这条隧道以内在西方在东方和英雄传奇 Gaoligong 正确文字的 strick 滑倒差错毗邻,它仍然不对贡尚·布洛克哪个构造单位合适清楚。尽管一些研究人员建议它是 Sundaland 岩层的北方结束,它的构造定义是相当模糊的。这篇论文报导我们 U-Pb 同位素的 geochronological 在贡尚·布洛克以内在 Gudang 片麻岩的花岗石上学习的新锆石。这研究在理解起源和西北的云南的构造环境起一个重要作用。 | SONG ShuGuang JI JianQing WEI ChunJing SU Li ZHENG YaDong SONG Biao ZHANG LiFei | 2007 | Chinese Science Bulletin2007，52，17： | 31 |
| 4 | Forming age and tectono-petrogenises of the Jiugequan ophiolite in the North Qilian Mountain,NW China显示文摘The Jiugequan ophiolite is one of the representative ophiolite fragments in the Early Paleozoic orogenic belt of the North Qilian Mountain.It has been drawn much attention and extensively studied in recent years.In this study,ion microprobe(SHRIMP) U-Pb dating was carried out for zircons from isotropic gabbro from the Jiugequan ophiolite.Eighteen analyses yield a relatively consistent apparent 206Pb/238U ages from 480 to 508 Ma with a weighted mean age of 490±5 Ma(MSWD=1.06),which is believed to be the crystallization age of the gabbro and thus the forming age of the Jiugequan ophiolite.Major and trace element geochemical study indicates that the diabase-basalts from the Jiugequan ophiolite have N-MORB and E-MORB characteristics with some subduction-related signatures.The petrological,geochemical and chronological data enable us to conclude that the Jiugequan ophiolite is most likely to be formed at a spreading center of back-arc basin during the early Ordovician,while the ancient Qilian oceanic plate subducted northwards.The acquisition of forming age and determination of tectonic setting for Jiugequan ophiolite provide significant constraints on the evolution of intra-oceanic subduction system in the North Qilian orogenic belt during the Early Paleozoic era. | XIA XiaoHong SONG ShuGuang | 2010 | Chinese Science Bulletin2010，55，18： | 33 |
| 5 | Qi-Qin Accretionary Belt in Central China Orogen: accretion by trench jam of oceanic plateau and formation of intra-oceanic arc in the Early Paleozoic Qin-Qi-Kun Ocean显示文摘Most orogenic belts have experienced a complex accretionary process with multiple episodes of sea?oor subduction and trench retreat.This accretionary process is important in continenta development and growth[1,2].Three giant orogens extend in China,e.g.,the Central Asian Orogen in the north,the Central China Orogen in the middle and the Himalayan Orogen in the southwest.They are keys for the formation of the Eurasian continent(Fig.1a).The Central China Orogen | Shuguang Song Liming Yang Yuqi Zhang Yaoling Niu Chao Wang Li Su Yanlin Gao | 2017 | Science Bulletin2017，62，15： | 28 |
| 6 | The geological characteristics of oceanic-type UHP metamorphic belts and their tectonic implications: Case studies from Southwest Tianshan and North Qaidam in NW China显示文摘The geological characteristics of ultrahigh-pressure (UHP) metamorphic belts formed by deep subduction of oceanic crust are summarized in this paper. Oceanic-type UHP metamorphic belt is characterized by its protolithic assemblage of typical oceanic crust, the peak metamorphic temperature <600℃, P-T path undergoing blueschist facies during prograde and retrograde metamorphic evolution, respectively, with low geothermal gradient of cold subduction. The further study of oceanic-type UHP metamorphic belt is very significant for constructing metamorphic reaction series of cold subduction zone, for understanding how aqueous fluids were transported into deep mantle and for classifying the types of UHP metamorphism in cold subduction zone. The uplift and exhumation mechanism of oceanic UHP metamorphic rocks is one of the most challenging problems in the study of UHP metamorphism, which is very important for understanding the geodynamic mechanism of solid Earth. As a traveler subducted into the mantle depth and then uplifted to the surface, oceanic-type UHP metamorphic belts witness the bulk process from the subduction to exhumation and is an ideal target to study the geochemical behavior and cycling of elements in subduction zones. The tectonic evolution of one convergent orogenic belt can be usually divided into two stages of oceanic subduction and followed continental subduction and collision, and the two best-established examples of orogenic belts are Alps and Himalaya. Therefore, the study of oceanic-type UHP metamorphic belt is the frontier of the current plate tectonic theory. As two case studies, the current status and existing problems of oceanic-type UHP metamorphic belts in Southwest Tianshan and North Qaidam, NW China, are reviewed in this paper. | ZHANG LiFei LU Zeng ZHANG GuiBin SONG ShuGuang | 2008 | Chinese Science Bulletin2008，53，20： | 22 |
| 7 | A huge oceanic-type UHP metamorphic belt in southwestern Tianshan, China: Peak metamorphic age and P-T path显示文摘Recent progress in the study of the UHP metamorphic belt in southwestern Tianshan,China,is summarized in this paper.This about 80-km-long and over 10-km-wide UHP belt has been recognized by the discovery of coesite,coesite pseudomorphs and other UHP minerals.It is the largest oceanic-type UHP metamorphic belt reported so far.It has formed due to northward subduction of the Tianshan Paleo-Ocean.U-Pb dating of metamorphic rims of zircons from a coesite-bearing garnet-phengite schist yields a peak UHP metamorphic ages of 320±3.7 Ma.Combined with ages of 233–226 Ma obtained from rims of zircons from retrograded eclogites,a long retrograde metamorphic evolution(>70 Ma)has been revealed.According to phase equilibria modeling,the P-T paths of both coesite-bearing eclogites and garnet-phengite schists are characterized by thermal relaxation,i.e.,the metamorphic temperature peak lags behind the pressure peak,indicating that the UHP rocks experienced slow and long heating and decompression during exhumation in the subduction channel.On the basis of the field observation that a small amount of eclogite lenses is wrapped in large volumes of metapelites,and the similar P-T paths of both rock types,we propose that the exhumation of the UHP eclogites from southwestern Tianshan,China,may have resulted from the exhumation of large volumes of low-density metapelites,which carried the denser eclogites to the Earth’s surface. | ZHANG LiFei DU JinXue Lü Zeng YANG Xin GOU LongLong XIA Bin CHEN ZhenYu WEI ChunJing SONG ShuGuang | 2013 | Chinese Science Bulletin2013，58，35： | 19 |
| 8 | Petrogenesis of Aoyougou high-silica adakite in the North Qilian orogen,NW China:Evidence for decompression melting of oceanic slab显示文摘A trondhjemitic body occurs in the Aoyougou area,the western part of the North Qilian orogen.It is geochemically characterized by high SiO 2,Na 2 O (high Na/K),elevated Sr/Y and (La/Yb) N,positive Sr anomaly,relatively enriched large ion lithophile elements (LILEs) and light rare earth elements (LREEs),and depleted Nb,Ta,Ti,resembling the high-silica adakite.Zircon U-Pb SHRIMP dating yields a weighted mean age of 438±3 Ma.This age is significantly younger than eclogitization ages of 460-490 Ma in the North Qilian orogen,suggesting that formation of the adakite postdates the subduction of oceanic crust in association with closure of the ancient Qilian Ocean.Whole-rock Sr and Nd isotopic analyses give initial ratios of I Sr =0.7044 0.7047 and Nd (t)=3.0 4.1,indicating that they are derived from partial melting of the juvenile oceanic crust.In view of the tectonic evolution of the North Qilian orogen,the high-silica adakite was probably derived from decompression melting of the exhumed eclogite at the depth of ~60 km. | YuXiao Chen XiaoHong Xia ShuGuang Song | 2012 | Chinese Science Bulletin2012，57，18： | 16 |
| 9 | ^(40)Ar/^(39)Ar isochron ages of lawsonite blueschists from Jiuquan in the northern Qilian Mountain,NW China,and their tectonic implications显示文摘Using laser 40Ar/39Ar dating method,we have gotten the metamorphic ages of lawsonite blueschist and epidote blueschist from Jiuquan,northern Qilian Mountain,NW China.The high quality laser 40Ar/39Ar dating of glaucophane from lawsonite blueschist gives an isochron age of 413±5 Ma.The isochron age obtained from phengite in epidote blueschist is 415±7 Ma.These data,combining with peak metamorphic P-T conditions and regional geological setting,allow us to infer that the lower limit of the ages of the prograde subduction metamorphism from lawsonite blueschist facies to epidote blueschist facies occurred at ca.413-415 Ma,which also suggests that the formation of lawsonite blueschist in the northern Qilian Mountain maybe resulted from the corner flow in the cold subduction zone.This study shows that the final closing time of the northern Qilian remnant oceanic basin is about 413-415 Ma,which also represents the convergent age between the North China Craton and the Qaidam block. | LIN YiHui ZHANG LiFei JI JianQing WANG QianJie SONG ShuGuang | 2010 | Chinese Science Bulletin2010，55，19： | 15 |
| 10 | Occurrence of Neoproterozoic low-grade metagranite in the western Beihuaiyang zone,the Dabie orogen显示文摘Based on detailed field investigations and petrographic observations,we discovered Neoproterozoic-emplaced granite from the metavolcanics of the Dingyuan Formation in the western Beihuaiyang zone,the Dabie orogen. This study reports the results of zircon U-Pb dating and preliminary petrographic observations on two metagranite samples. The studied rocks experienced epidote-amphibolite facies metamorphism and strong structural deformation. Their U-Pb ages are 726 ± 6 and 758 ± 12 Ma,respectively,similar to those for the Luzhenguan complex in the eastern segment of the Beihuaiyang zone. In combination with previously determined 635 ± 5 Ma low-grade metagabbro,this study suggests the occurrence of at least two types of Neoproterozoic intrusive rocks in the Beihuaiyang zone,the northern margin of the South China Block (SCB):726-758 Ma metagranite and 635 Ma metagabbro. These rocks occur within the metamorphosed Ordovician volcanic zone (originally named the Dingyuan Formation) and are in tectonic contact to each other,but they formed in different tectonic settings. The protolith ages for the Neoproterozoic low-grade metaigneous rocks are in good agreement not only with ages for two episodes of mid-and late-Neoproterozoic mafic and felsic magmatism in the Suizhou and Zaoyang area,Hubei Province,but also agree with protolith ages of ultrahigh-pressure metaigneous rocks in the Dabie-Sulu orogenic belt. In view of their tectonic relationships to country rocks,it appears that these Neoproterozoic low-grade rocks are exotic and they may have been detached and scraped from subducting SCB crust in the early Triassic during the initial continental subduction,and thrusted over Paleozoic metamorphosed rocks in the southern margin of the North China Block during continental collision. | LIU YiCan LIU LiXiang GU XiaoFeng LI ShuGuang SONG Biao | 2010 | Chinese Science Bulletin2010，55，30： | 10 |
| 11 | Single-cell transcriptomic atlas of primate cardiopulmonary aging显示文摘Aging is a major risk factor for many diseases,especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019(COVID-19).Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed.Here,we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung,heart and artery,the top tissues targeted by SARS-CoV-2.Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging.With age,expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2(ACE2)was increased in the pulmonary alveolar epithelial barrier,cardiomyocytes,and vascular endothelial cells.We found that interleukin 7(IL7)accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-κB-dependent manner.Furthermore,treatment with vitamin C blocked IL7-induced ACE2 expression.Altogether,our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2,suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. | Shuai Ma Shuhui Sun Jiaming Li Yanling Fan Jing Qu Liang Sun Si Wang Yiyuan Zhang Shanshan Yang Zunpeng Liu Zeming Wu Sheng Zhang Qiaoran Wang Aihua Zheng Shuguang Duo Yang Yu Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Moshi Song Weiqi Zhang Guang-Hui Liu | 2021 | Cell Research2021，31，4： | 10 |
| 12 | CH_4-rich fluid inclusions in the Yushigou mantle peridotite and their implications, North Qilian Mountains, China显示文摘Studies were carried out on the early phase of fluid inclusions which occur in residual olivines in harzburgite from the Yushigou ophiolitic mantle peridotite, the North Qilian Mountains. Components of these inclusions, analyzed by micro laser Raman spectroscopy, are dominantly CH4 (70%-95%) with minor H2, N2, H2S,CO2,C2H4,C2H6, and C3H6, but | SU Li, SONG Shuguang and WANG ZhihaiXi’an Institute of Geology and Mineral Resources, CAGS, Xi’an 710054, China | 1999 | Chinese Science Bulletin1999，44，21： | 10 |
| 13 | Rheological Properties of Mantle Peridotites at Yushigou in the North Qilian Mountains and Their Implicationsfor Plate Dynamics显示文摘This paper discusses in detail the deformation textures, glide system, petrofabrics and olivine dislocation microstructures of mantle peridotites at Yushigou in the North Qilian Mountains, northwestern China. The peridotites have undergone high-pressure, high-temperature and low-strain rate plastic flow deformation. According to the dynamic recrystallized-grain size of olivine and the average spacing between the dislocation walls as well as the chemical composition of enstatite, the authors calculated the rheological parameters of the ancient upper mantle in the study area as follows: temperatures 1025-1093℃; pressures 3043-4278 MPa; depths 95-132 km; deviatoric stress 28-32 MPa; strain rates 0.2×10-14-2.13×10-14s-1 and equivalent viscosities 0.45×1020-4.65×1020 Pa · s. These parameters suggest that the position where plastic flow took place was correspondent to the low-velocity zone beneath the oceanic lithosphere and that oceanization characterized by middle-velocity (1-3 cm/a) sea-floor | SONG Shuguang SU Li | 1998 | Acta Geologica Sinica(English Edition)1998，72，2： | 9 |
| 14 | First discovery of coesite in eclogite from East Kunlun, northwest China显示文摘Ultrahigh-pressure (UHP)metamorphism plays important roles in continental dynamics.Understanding of this process has been enhanced by the discovery of coesite and micro-diamond from supracrustal rocks [1].Such UHP mineral inclusions provide unequivocal evidence that the least dense part of the lithosphere can be buried to 100-150km or more,and then returned to the surface.Coesite,an ultrahigh-pressure polymorph of SiO2stable above 2.7GPa at metamorphic temperatures,is one of the most important index minerals for UHP metamomhism [1,2]. | Hengzhe Bi Shuguang Song Jinlong Dong Liming Yang Shengsheng Qi Mark B.Allen | 2018 | Science Bulletin2018，63，23： | 4 |
| 15 | Exotic origin of the Chinese continental shelf显示文摘The history of western Pacific subduction and its relation to eastern China are big issues for geological investigations[1,2].Many models have been proposed for interpreting the tectonic scenarios of eastern China since the Mesozoic,but most have centered on the lithosphere destruction of the North China Craton[3–6]with increasing emphasis on the effect | Shuguang Song | 2015 | Science Bulletin2015，60，18： | 3 |
| 16 | Application of microprobe-based flank method analysis of Fe^3+ in garnet ofNorth Qilian eclogite and its geological implication显示文摘A newly developed microprobe-based methodology(the Flank Method)for Fe^(3+)/RFe quantification has been successfully applied to some natural garnets from the North Qilian eclogites by JEOL JXA-8100microprobe at Peking University.The results demonstrated an obvious discrepancy in comparison with the outcomes by conventional stoichiometric calculations.This methodology allows to measure theFe^(3+)/Rmeasurement of Fe^(3+)According to the compositional zonation displayed in the studied eclogitic garnets from North Qilian,a prograde metamorphic°C to 22 kbar,600°C was reconstructed.More interestingly,the measured Fe^(3+)/RFe ratios in garnets decreasing from core to rim may probably imply that the oxygen fugacity(f O_2)declines with the depth of the subduction zone. | Xiaoli Li Shuguang Song Lifei Zhang E. Heidi Hofer | 2018 | Science Bulletin2018，63，5： | 3 |
| 17 | Tracing the 850-Ma continental flood basalts from a piece of subducted continental crust in the North Qaidam UHPM belt, NW China显示文摘 | Shuguang Song Li Su Xian-hua Li Guibing Zhang Yaoling Niu Lifei Zhang | 2010 | Precambrian Research2010，，4： | 2 |
| 18 | Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects显示文摘 | Dongxin Zhao Song Chen Shuguang Duo Chengang Xiang Jun Jia Mina Guo Wei Lai Shichun LU Hongkui Deng | 2013 | Cell Research2013，23，1： | 2 |
| 19 | Geochronology of diamond-bearing zircons from garnet peridotite in the North Qaidam UHPM belt, Northern Tibetan Plateau: A record of complex histories from oceanic lithosphere subduction to continental collision显示文摘 | Shuguang Song Lifei Zhang Yaoling Niu Li Su Ping Jian Dunyi Liu | 2005 | Earth and Planetary Science Letters2005，，1： | 1 |
| 20 | Petrology, geochemistry and isotopic ages of eclogites from the Dulan UHPM Terrane, the North Qaidam, NW China显示文摘 | Shuguang Song Jingsui Yang J.G Liou Cailai Wu Rendeng Shi Zhiqin Xu | 2003 | LITHOS2003，，3： | 1 |
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