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| 1 | Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy显示文摘Tumor nanovaccines have potential applications in the prevention and treatment of malignant tumors.However,it remains a longstanding challenge in exploiting efficient nanocarriers for inducing potent specifically cellular immune responses.Toward this objective,we herein explore an intensive tumor immunotherapeutic strategy by combining mannosylated nanovaccines and gene regulated PD-L1 blockade for immune stimulation and killing activity.Here,we fabricate a mannose modified PLL-RT(Man-PLL-RT)mediated nanovaccines with dendritic cells(DCs)targeting capacity.Man-PLL-RT is capable of co-encapsulating with antigen(ovalbumin,OVA)and adjuvant(unmethylated cytosine-phosphate-guanine,CpG)by electrostatic interaction.This positively charged Man-PLL-RT/OVA/CpG nanovaccines can facilitate the endocytosis,maturation and cross presentation in DCs.However,the nanovaccines arouse limited inhibition of tumor growth,which is mainly due to the immunosuppressed microenvironment of tumors.Combining tumor nanovaccines with gene regulated PD-L1 blockade leads to an obvious tumor remission in B16F10 melanoma bearing mice.The collaborative strategy provides essential insights to boost the benefits of tumor vaccines by regulating the checkpoint blockade with gene therapy. | Jie Chen Huapan Fang Yingying Hu Jiayan Wu Sijia Zhang Yuanji Feng Lin Lin Huayu Tian Xuesi Chen | 2022 | Bioactive Materials2022，7，1： | 2 |
| 2 | News in Brief | LIU Jiayan & QIAN Fang | 2009 | China City Planning Review2009，18，4： | 0 |
| 3 | 共担与赋能:有温度的社区与住房显示文摘Introduction On Apr.15-16,2023,the 2022 Annual Conference of the Housing and Community Planning Committee of the Urban Planning Society of China(UPSC)was successfully held at the Chongqing Planning Exhibition Gallery,Chongqing.The conference was hosted by the Housing and Community Planning Committee of the UPSC. | 尹稚 王宇 江维 Yu Ying Liu Jiayan Yao Nan Wang Chenghui Fang Xiaotao Wang Ying Xi Wenqin Pan Chenyue Mou Yanchuan Wei Wei Li Yun Xiao Xiao Chen Yulin Zhao Di Liu Wei Zhang Jiuhe Deng Yi | 2023 | China City Planning Review2023，32，4： | 0 |
| 4 | PBK/TOPK promotes chemoresistance to oxaliplatin in hepatocellular carcinoma cells by regulating PTEN显示文摘Oxaliplatin(OXA)resistance limits the efficiency of treatment for hepatocellular carcinoma(HCC).Studies have shown that the PDZ-binding kinase(PBK)plays important roles in tumors.However,the role of PBK in HCC is still a problem.In this study,we explored whether PBK is involved in the chemoresistance to OXA in HCC.Expressions of PBK in six HCC cell lines and one human hepatocytes line were determined by real-time quantitative PCR and western blot analysis.SNU-182 and HepG2 cells were chosen to induce OXA resistance.PBK was silenced or overexpressed in OXA-resistant and sensitive cell lines.Then,cell proliferation,migration,and invasion were measured by cholecystokinin-8 assay and Transwell assay,respectively.The Cancer Genome Atlas dataset showed that PBK is highly expressed in HCC and signifies poor prognosis to patient with HCC.Results showed that expression of PBK in HCC cells was significantly higher than that in THLE2 cells,and it was further increased in OXA-resistant HCC cells.Silencing of PBK promoted the sensitivity of drug-resistant HCC cells to OXA.Overexpression of PBK relieved the apoptosis induced by OXA and promoted the migration and invasion of OXA-sensitive HCC cells.Thus,this study revealed that high PBK expression is correlated with OXA resistance in HCC cells,which may provide a promising therapeutic target for treating HCC. | Hongmin Cao Mei Yang Yufeng Yang Jiayan Fang Yejia Cui | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 0 |
| 5 | Silver-Mediated N-Trifluoromethylation of Amides and Peptides显示文摘Summary of main observation and conclusion We report herein the direct N-trifluoromethylation of N-H amides.Promoted by AgOTf and 2-fluoro-pyridine,the reaction of a variety of amides with Selectfluor,TMSCF3 and CsF proceeds smoothly at room temperature leading to the corresponding N-trifluoromethylated products in satisfactory yields.The protocol is also applicable to amino acid derivatives,resulting in efficient and chemoselective W-trifluoromethylation of di-and tri-peptides with retention of configuration.A mechanism involving reductive elimination of Ag(Ⅲ)intermediates to form N—CF3 bonds is proposed. | Zhenzhen Zhang Jiayan He Lin Zhu Haiwen Xiao Yewen Fang Chaozhong Li | 2020 | Chinese Journal of Chemistry2020，38，9： | 0 |
| 6 | 城市环境对心理健康的影响研究进展显示文摘Neuroscience research shows that the environment shapes people’s physical and mental health through its effects on the brain and nervous system.Currently,mental health issues are increasingly highlighted,and research on the psychological impacts of the urban environment brought by urbanization has received increasing attention.This article,from an view of multidisciplinary perspective,gives a brief overview of the concepts and theories relating to urban environment and mental health,using Citespace to investigate various domestical and international studies in this field,and introducing research progresses in terms of the overall characteristics of urban environment,their impacts on mental health,and the main environmental influence factors and functional mechanism.It then summarizes the weakness of the studies in China and makes proposals for furthering the research in the future,such as setting up a multidisciplinary integrated theoretical method framework,deepening factor identification,process analysis,and mechanism interpretation,promoting the establishment of evidence-based healthy city planning and design,and finally exploring research paradigms suitable for Chinese conditions and pushing for the development of urban public mental health enhancement strategies with Chinese characteristics. | 戚均慧 罗非 林戈 Shan Feng Qian Fang(Translated) Liu Jiayan(Proofread) | 2023 | China City Planning Review2023，32，2： | 0 |
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