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| 1 | IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice显示文摘Strigolactones (SL ) ,一组类胡萝卜素导出 terpenoid 内酯,是压制射击由禁止腋的芽的长出分叉的 root-to-shoot 植物激素。矮子 53 (D53 ) ,表明小径的 SL 的关键抑压者,被推测调整 SL 反应的下游的 transcriptional 网络。然而, D53 指向的下游的抄写因素还都没被报导。这里,我们报导那理想的植物体系结构 1 (IPA1 ) ,在米饭的植物体系结构的一个关键管理者,在调整 tiller 数字和导致 SL 的基因表示作为 D53 的一个直接下游的部件工作。我们证明 D53 在 vivo 并且在 vitro 与 IPA1 交往并且压制 IPA1 的 transcriptional 激活活动。我们进一步证明 IPA1 能直接绑在 D53 倡导者并且在导致 SL 的 D53 表示的反馈规定起一个关键作用。这些调查结果表明 IPA1 是可能的与 D53 行动到的长推测的抄写因素之一调停在米饭的调整 SL 的 tiller 发展。 | Xiaoguang Song Zefu Lu Hong Yu Gaoneng Shao Jinsong Xiong Xiangbing Meng Yanhui Jing Guifu Liu Guosheng Xiong Jingbo Duan Xue-Feng Yao Chun-Ming Liu Hongqing Li Yonghong Wang Jiayang Li | 2017 | Cell Research2017，27，9： | 48 |
| 2 | Construction of a Genome-Wide Mutant Library in Rice Using CRISPR/Cas9显示文摘 | Meng, Xiangbing Yu, Hong Zhang, Yi Zhuang, Fengfeng Song, Xiaoguang Gao, Songsong Gao, Caixia Li, Jiayang | 2017 | Molecular Plant2017，10，9： | 46 |
| 3 | Development of gene-tagged molecular markers for starch synthesis-related genes in rice显示文摘Improving grain quality is an important goal in breeding new elite rice varieties,requiring effective tools for the identification of target genotypes.Molecular marker-aided selection(MAS),combined with conventional breeding approaches,enables us to pre-cisely identify the individual genotypes that are associated with different grain quality features,which can dramatically improve the breeding efficiency.However,to date,the number of molecular markers used in MAS for grain quality improvement is still somewhat limited.In this study,based on our previous study that rice grain quality is strongly associated with starch synthesis in the endosperm,we developed 51 gene-tagged molecular markers according to sequence variations in 18 starch synthesis-related genes from 16 typical rice cultivars.These markers can discriminate the different alleles among rice germplasms.These novel markers will provide effective tools in improving grain quality via the breeding new elite rice varieties. | TIAN ZhiXi YAN ChangJie QIAN Qian YAN Song XIE HuiLan WANG Fang XU JieFen LIU GuiFu WANG YongHong LIU QiaoQuan TANG ShuZhu LI JiaYang GU MingHong | 2010 | Chinese Science Bulletin2010，55，33： | 12 |
| 4 | Robust genome editing of CRISPR-Cas9 at NAG PAMs in rice显示文摘Dear Editor,The CRISPR-Cas9(clustered regularly interspaced short palindromic repeats/Cas9)system has been widely used for a variety of applications,including targeted gene knockout,gene insertion,gene replacement and base editing.Despite its wide use,the genome editing using CRISPR-Cas9 is performed almost exclusively at sites containing canonical NGG protospacer adjacent motifs(PAMs).To overcome the PAM constraint of the CRISPR-Cas9 system,many attempts have been made to develop various Cas9 orthologs | Xiangbing Meng Xixun Hu Qing Liu Xiaoguang Song Caixia Gao Jiayang Li Kejian Wang | 2018 | Science China(Life Sciences)2018，61，1： | 11 |
| 5 | Multicenter phaseⅡstudy of apatinib single or combination therapy in HER2-negative breast cancer involving chest wall metastasis显示文摘Objective:Breast cancer(BC)with chest wall metastasis(CWM)usually shows rich neovascularization.This trial explored the clinical effect of apatinib on human epidermal growth factor receptor 2(HER2)-negative advanced BC involving CWM.Methods:This trial involved four centers in China and was conducted from September 2016 to March 2020.Patients received apatinib 500 mg/d[either alone or with endocrine therapy if hormone receptor-positive(HR+)]until disease progression or unacceptable toxicity.Progression-free survival(PFS)was the primary endpoint.Results:We evaluated 26 patients for efficacy.The median PFS(mPFS)and median overall survival(mOS)were4.9[range:2.0-28.5;95%confidence interval(95%CI):2.1-8.3]months and 18(range:3-55;95%CI:12.9-23.1)months,respectively.The objective response rate(ORR)was 42.3%(11/26),and the disease-control rate was76.9%(20/26).In the subgroup analysis,HR+patients compared with HR-negative patients had significantly improved mPFS of 7.0(95%CI:2.2-11.8)months vs.2.3(95%CI:1.2-3.4)months,respectively(P=0.001);and mPFS in patients without or with chest wall radiotherapy was 6.4(95%CI:1.6-19.5)months vs.3.0(95%CI:1.3-4.6)months,respectively(P=0.041).In the multivariate analysis,HR+status was the only independent predictive factor for favorable PFS(P=0.014).Conclusions:Apatinib was highly effective for BC patients with CWM,especially when combined with endocrine therapy.PFS improved significantly in patients with HR+status who did not receive chest wall radiotherapy.However,adverse events were serious and should be carefully monitored from the beginning of apatinib treatment. | Huiping Li Cuizhi Geng Hongmei Zhao Hanfang Jiang Guohong Song Jiayang Zhang Yaxin Liu Xinyu Gui Jing Wang Kun Li Zhongsheng Tong Fangyuan Zhao Junlan Yang Guoliang Chen Qianyu Liu Xu Liang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 4 |
| 6 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 7 | OsMPK4 promotes phosphorylation and degradation of IPA1 in response to salt stress to confer salt tolerance in rice显示文摘Salt stress adversely affects plant growth,development,and crop yield.Rice(Oryza sativa L.)is one of the most salt-sensitive cereal crops,especially at the early seedling stage.Mitogen-activated protein kinase(MAPK/MPK)cascades have been shown to play critical roles in salt response in Arabidopsis.However,the roles of the MPK cascade signaling in rice salt response and substrates of Os MPK remain largely unknown.Here,we report that the salt-induced Os MPK4-Ideal Plant Architecture 1(IPA1)signaling pathway regulates the salt tolerance in rice.Under salt stress,Os MPK4 could interact with IPA1 and phosphorylate IPA1 at Thr180,leading to degradation of IPA1.Genetic evidence shows that IPA1 is a negative regulator of salt tolerance in rice,whereas Os MPK4 promotes salt response in an IPA1-dependent manner.Taken together,our results uncover an Os MPK4-IPA1 signal cascade that modulates the salt stress response in rice and sheds new light on the breeding of salt-tolerant rice varieties. | Meiru Jia Nan Luo Xiangbing Meng Xiaoguang Song Yanhui Jing Liquan Kou Guifu Liu Xiahe Huang Yingchun Wang Jiayang Li Bing Wang Hong Yu | 2022 | Journal of Genetics and Genomics2022，49，8： | 2 |
| 8 | Poisonings Caused by Wild Mushroom Containing Amanitin Toxins—Shaoxing City,Zhejiang Province,China,2019显示文摘What is already known about this topic?Among all food poisoning,poisonings caused by wild mushrooms containing amanitin toxins have the highest case fatality rate.Amanitin toxins can cause acute liver function damage,and symptoms of the poisoning can include vomiting and diarrhea in early stages and progressive liver damage 2–3 days later.What is added by this report?Before 2019,there were about 1–2 cases of wild mushroom containing amanitin toxins poisoning each year in Zhejiang Province.In 2019,10 cases were identified through disease investigation and toxin detection and biological identification in Shaoxing City,Zhejiang Province.All patients had a history of wild mushroom consumption.What are the implications for public health practice?In the summer,some people collect the wild mushrooms for consumption.In China,about 20 species of mushrooms can cause death,and most people lack the ability to identify which mushrooms are edible.To combat this,effective science popularization and prevention and control work will be able to reduce the occurrence of related poisoning events. | Xiaomin Xu Liang Sun Yizhe Zhang Jiayang Song Chao Xing Hongshun Zhang | 2020 | China CDC weekly2020，2，29： | 2 |
| 9 | Nitric oxide negatively regulates gibberellin signaling to coordinate growth and salt tolerance in Arabidopsis显示文摘In response to dynamically altered environments,plants must finely coordinate the balance between growth and stress responses for their survival.However,the underpinning regulatory mechanisms remain largely elusive.The phytohormone gibberellin promotes growth via a derepression mechanism by proteasomal degradation of the DELLA transcription repressors.Conversely,the stress-induced burst of nitric oxide(NO)enhances stress tolerance,largely relying on NO-mediated S-nitrosylation,a redox-based posttranslational modification.Here,we show that S-nitrosylation of Cys-374 in the Arabidopsis RGA protein,a key member of DELLAs,inhibits its interaction with the F-box protein SLY1,thereby preventing its proteasomal degradation under salinity condition.The accumulation of RGA consequently retards growth but enhances salt tolerance.We propose that NO negatively regulates gibberellin signaling via S-nitrosylation of RGA to coordinate the balance of growth and stress responses when challenged by adverse environments. | Lichao Chen Shuhao Sun Chun-Peng Song Jian-Min Zhou Jiayang Li Jianru Zuo | 2022 | Journal of Genetics and Genomics2022，49，8： | 1 |
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