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| 1 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 2 | Influence of mass-flow ratio of inner to outer secondary air on gas-particle flow near a swirl burner显示文摘The influence of mass-flow-rate ratio of inner to outer secondary air on gas-particle flow characteristics was determined in the near-burner region of a centrally fuel-rich swirl coal combustion burner.Velocity and particle volume flux profiles and normalized particle number concentrations were obtained.Peaks in tangential mean velocity and three-dimensional root-mean-square fluctuation velocities were found to decrease as the mass-flow-rate ratio increased.Moreover,the peaks in the mean axial velocities and particle volume flux near the wall increased,whereas those near the chamber axis decreased.Simultaneously,both recirculation zone and swirl number decreased as the mass-flow-rate ratio increased. | Jianping Jing Chunming Zhang Wei Suna Jieruo Ana Jinsheng Bia Zhengqi Lib | 2013 | Particuology2013，11，5： | 2 |
| 3 | Spondyloarthritis in China 显示文摘 | Rong J Jieruo G | 2013 | Curr OpinRheumatol2013，25，： | 1 |
| 4 | Low prevalence of hepatitis B virus infection in patients with systemic lupus erythematosus in southern China显示文摘 | Jijun Zhao Minli Qiu Meirong Li Caisheng Lu Jieruo Gu | 2010 | Rheumatology International2010，，12： | 1 |
| 5 | Fractalkine stimulates cell growth and increases its expression via NF ‐κ B pathway in RA ‐ FLS显示文摘 | Xinghua Guo Yunfeng Pan Chuyin Xiao Yuqiong Wu Daozhang Cai Jieruo Gu | 2012 | Int J Rheum Dis2012，，3： | 1 |
| 6 | Spondyloarthritis in China 显示文摘 | Rong J Jieruo G | 2013 | Curr Opin Rheumatol2013，25，4： | 1 |
| 7 | Is there an HEA - B27 - induced endoplasmic reticulum unfolded protein response (UPR) in the synovial cells of spondyloathropathy (SpA) patients显示文摘 | JIERUO G U HERMANN E M BAETEN D | 2001 | Arthritis Rheum2001，45，： | 1 |
| 8 | Spondyloarthritis in China显示文摘 | Rong J Jieruo G | 2013 | Curr Opin Rheumatol2013，25，4： | 1 |
| 9 | Pathogenesis of ankylosing spon-dylitis显示文摘 | Lai-Shan T Jieruo G David Y | 2010 | Nat Rev Rheumatol2010，6，7： | 1 |
| 10 | Is there an HLA-B27-induced endoplasmic reticulum unfold protein response (UPP) in the synovial cells of spondyloathropathy(SpA) patients显示文摘 | Jieruo G U Hermann E M Baeten D | 2001 | Arthritis Rheum2001，45，1： | 1 |
| 11 | Fractalkine stimulates cell growth and increases its expression via NF ‐κ B pathway in RA ‐ FLS显示文摘 | Xinghua Guo Yunfeng Pan Chuyin Xiao Yuqiong Wu Daozhang Cai Jieruo Gu | 2012 | Int J Rheum Dis2012，，3： | 1 |
| 12 | Correction: Autophagy receptor CCDC50 modulates STING-mediated interferon response in viral infection and autoimmune disease显示文摘Correction to:Cellular&Molecular Immunology http://gffzzd3cc09b8251d45dfsukw5nnqukvn960bx.ffgz.tsg.suse.edu.cn/10.1038/s41423-021-00758-w In the version of this article initially published,one unintended error was made during manuscript editing.The title of the article was not in accordance with that of the original manuscript,and the correct statement is“Autophagy receptor CCDC50 modulates STING-mediated interferon response in viral infection and autoimmune disease”.The results and conclusions are not affected. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，12： | 0 |
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