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| 1 | Enhancement in antinociceptive and anti-inflammatory effects of tramadol by transdermal proniosome gel显示文摘Oral therapy of tramadol,an opiate analgesic,undergoes extensive hepatic metabolism and requires frequent administration.Transdermal therapy by virtue can overcome these issues and can improve the efficacy and reduce abuse liability of tramadol.The aim of this research was to investigate the possibility of transdermal delivery of tramadol by formulating proniosome gel and evaluate its therapeutic potential in vivo.The effect of formulation composition as well as amount of drug on physicochemical characteristics of prepared proniosomes were examined.Best proniosome gel(F4)was selected and evaluated for drug release,stability and transdermal efficacy by ex vivo and in vivo experiments.The vesicles demonstrated optimal properties including spherical shape,nanosize with good entrapment efficiency,adequate zeta potential,higher stability and greater transdermal flux.The amorphization and dispersion of tramadol in the aqueous core of proniosome vesicles was confirmed by differential scanning calorimeter.Release profile of F4 was distinct(P<0.001)from control and displayed steady and prolonged tramadol release by Fickian diffusion.Transdermal therapy of F4 showed prominent reduction of induced twitches(P<0.005)in mice and edema(P<0.05)in rats,as compared to oral tramadol.The improvement in clinical efficacy of tramadol in transdermal therapy is correlated with the pharmacokinetic data observed.In conclusion,the observed improvement in antinociceptive and anti-inflammatory effects from proniosome carriers signifies its potential to be a suitable alternative to oral therapy of tramadol with greater efficacy. | Jigar Shah Anroop B.Nair Hiral Shah Shery Jacob Tamer M.Shehata Mohamed Aly Morsy | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，6： | 3 |
| 2 | Synthesis and in vitro antimicrobial activity of N-arylquinoline derivatives bearing 2-morpholinoquinoline moiety显示文摘A new series of N-arylquinoline derivatives 5a-x bearing 2-morpholinoquinoline moiety has been synthesized by one pot base catalyzed cyclocondensation reaction of 2-morpholinoquinoline-3-carbaldehydes 2a-c,malononitrile 3 andβ-enaminones 4a-h. All the synthesized compounds were screened for their in vitro antimicrobial activity against six bacterial pathogens,namely Streptococcus pneumoniae,Clostridium tetani,Bacillus subtilis,Salmonella typhi,Vibrio cholerae,Escherichia coli and against two fungal pathogens,Aspergillus fumigatus and Candida albicans using broth microdilution MIC method.Of the compounds studied,majority of the compounds were found to active against C.tetani,B.subtilis and C.albicans as compared to first-line standard drugs. | Jigar A.Makawana Manish P.Patel Ranjan G.Patel | 2012 | Chinese Chemical Letters2012，23，4： | 2 |
| 3 | Biomechanical evaluation of surgical constructs for stabilization of cervical teardrop fractures显示文摘 | Allyson Ianuzzi Isidoro Zambrano Jigar Tataria Azeema Ameerally Marc Agulnick Jesse S. Little Goodwin Mark Stephen Partap S. Khalsa | 2006 | The Spine Journal2006，，5： | 1 |
| 4 | Polyurethane adhesive system from biomaterial-based polyol for bonding wood显示文摘 | Sandip D Desai Jigar V Patel Vijay Kumar Sinha | 2003 | International Journal of Adhesion and Adhesives2003，23，： | 1 |
| 5 | TRAVOS: Trust and Reputation in the Context of Inaccurate Information Sources显示文摘 | W. T. Luke Teacy Jigar Patel Nicholas R. Jennings Michael Luck | 2006 | Autonomous Agents and Multi - Agent Systems2006，，2： | 1 |
| 6 | Modeling the effect of heavy vehicles on sign visibility at multilane highways 显示文摘 | Ahmed AI-Kaisy Jigar Bhatt Hesham Rakha | 2005 | Journal of Transportation Engineering2005，131，3： | 1 |
| 7 | Ceric ammonium nitrate induced grafting of polyacrylamide onto carboxymethyl chitosan显示文摘 | Jigar M J Vijay K S | 2007 | Carbohydrate Polymers2007，67，3： | 1 |
| 8 | Polyurethane adhesive system from biomaterial-based polyol for bonding wood显示文摘 | DESAI SANDIP D PATEL JIGAR V SINHA VIJAY KU- MAR | 2003 | International Journal of Adhesion Adhesives2003，23，5： | 1 |
| 9 | Enhancement of dissolution rate of valdecoxib by solid dispersions technique with PVP K30&PEG 4000 : preparation and in vitro evaluation 显示文摘 | Jigar S S Vasanti B Anroop H V | 2009 | Incl Phenom Macrocyel Chem2009，63，： | 1 |
| 10 | A Review on Nu- merical and Expermental Study of Screw Conveyor 显示文摘 | Jigar Patel Sumant Patel Snehal Patel | 2012 | Re- view Article2012，，6： | 1 |
| 11 | Polyurethaneadhesive system from biomaterial-basedpolyol for bondingwood显示文摘 | SANDIP D DESAI JIGAR V PATEL VIJAY K SINHA | 2003 | International Journal of Adhesion & Adhesives2003，，23： | 1 |
| 12 | TRAVOS: trust and reputation in the context of inaccurate information sources显示文摘 | TEACY W T JIGAR P JENN!NGS N R | 2006 | Autonomous Agents and Multi-agent Systems2006，12，2： | 1 |
| 13 | Polyurethane adhesive system from biomaterial-based polyol for bonding wood 显示文摘 | Sandip D Desai Jigar V Patel Vijay Kumar Sinha | 2003 | International Journal of Adhesion and Adhesives2003，，23： | 1 |
| 14 | TRAVOS: Trust and Reputation in the Context of Inaccurate Information Sources显示文摘 | W. T. Luke Teacy Jigar Patel Nicholas R. Jennings Michael Luck | 2006 | Autonomous Agents and Multi - Agent Systems2006，，2： | 1 |
| 15 | TRAVOS: Trust and Reputation in the Context of Inaccurate Information Sources显示文摘 | Luke Teacy W T Patel Jigar Jennings Nicholas R | 2006 | Journal of Autonomous Agent Multi-Agent System2006，12，： | 1 |
| 16 | TRAVOS: Trust and Reputation in the Context of Inaccurate Information Sources显示文摘 | Teacy W T Jigar P Jennings N R | 2006 | Autonomous Agents and Multi-agent Systems2006，12，2： | 1 |
| 17 | Polyurethane adhesive system from biomaterial-based polyol for bonding wood显示文摘 | Sandip D Desai Jigar V Patel Vijay Kumar Sinha | 2003 | International Journal of Adhesion and Adhesives2003，23，： | 1 |
| 18 | Polyurethane adhesive system from biomaterial-based polyol for bonding wood 显示文摘 | Sandip D Desai Jigar V Patel | 2003 | International Journal of Adhesion & Adhesives2003，，23： | 1 |
| 19 | Wilson's disease:‘face of giant panda’and‘trident’signs together显示文摘 | Jigar R Parekh Preetesh R | 2014 | Oxford Medical Case Reports2014，，1： | 1 |
| 20 | Pet Waste Management by Chemical Recycling: A Review显示文摘 | Vijaykumar Sinha Mayank R. Patel Jigar V. Patel | 2010 | Journal of Polymers and the Environment2010，，1： | 1 |
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