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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Degradation of nitrobenzene by a Pseudomonas pseudoalcaligenes显示文摘 | Shirley F Nishino Jim C Spain | 1993 | Apply Environ Microbiol1993，59，7： | 1 |
| 3 | Purification and characterization of nitrobenzene nitroreductase from Pseudomonas pseudoalcaligenes JS45显示文摘 | Charles C Somerville Shirley F Nishino Jim C Spain | 1995 | Journal of Bacteriology1995，177，13： | 1 |
| 4 | Iron-binding ability of melanoidins from food and model systems显示文摘 | MORALES F J FERN(A)NDEZ-FRAGUAS C JIM(E)NEZ-P(E)REZ S | | 0，，04： | 1 |
| 5 | The banana(Musa acuminata)genome andthe evolution of monocotyledonous plants显示文摘 | HONT A D DENOEUD F AURY J M BAURENSF C CARREELF GARSMEUR O NOEL B BOCS S DROC G ROUARD M SILVA C D JABBARI K CARDI C POULAIN J SOUQUET M LABADIEK JOURDA C LENGELLE J MARGUERITE R G ALBERTI A BERNARD M CORREA M AYYAMPALAYAM S MCKAIN M R JIM L M | 2012 | Nature2012，488，： | 1 |
| 6 | Degradation of Nitrobenzene by a Pseudomonas pseudoalcaligenes显示文摘 | Shirley F Nishino Jim C Spain | 1993 | Appl Environ Microbiol1993，59，8： | 1 |
| 7 | Indoor pedestrian navigation using an INS/EKF framework for yaw drift reduction and a foot-mounted IMU显示文摘 | Jiménez A R Seco F Prieto J C | 2010 | Institute of Electrical&Electronics Engineers2010，，： | 1 |
| 8 | Mice lacking Pinl develop normally,but are defective in entering cell cycle from G(0)arrest显示文摘 | Fu JIM Ori F Takahashik U Chida C | 1999 | Biochem Biophys Res Commun1999，265，： | 1 |
| 9 | New cements for the 21st century:The pursuit of an alternative to Portland cement显示文摘 | Shi C J Jiménez A F Palomo A A | 2011 | Cement and Concrete Research2011，41，7： | 1 |
| 10 | The pH as a key parameter in the choice between coagulation and electrocoagulation for the treatment of wastewaters显示文摘 | Ca(n)izares P Jiménez C Martínez F | | 0，，01： | 1 |
| 11 | Local responses to inundation and defarming in the Reservoir Region of the Three Gorges Project (China) 显示文摘 | Jim C Y Yang F Y | 2006 | Environmental Management2006，38，4： | 1 |
| 12 | Degradation of nitrobenzene by a Pseudomonas pseudoalcaligene显示文摘 | Jim C S | 1993 | Appl Environ Microbiol1993，59，8： | 1 |
| 13 | 3D collision detection:a survey显示文摘 | JIM(E)NEZ P THOMAS F TORRAS C | 2001 | Computers and Graphics2001，25，2： | 1 |
| 14 | Development of a genetic linkage map and identification of homologous linkage groups in sweetpotato using muhiple-dose AFLP markers显示文摘 | Jim C C F Yencho G C Albert K | 2008 | Mol Breeding2008，21，： | 1 |
| 15 | Band-gap Tailoring of ZnO by Means of Heavy Al doping显示文摘 | Sernelius B E Berggren K F Jim Z C | 1988 | Physics Review B1988，37，10： | 1 |
| 16 | Joint channel and frequency offset estimation in MIMO-OFDM systems with insuffi-cient cyclic prefix显示文摘 | AMO C P D JIMéNEZ V P G GARCíA M J F G | | 0，，22： | 1 |
| 17 | Biogenic amines in meat and meat products显示文摘 | Ruiz-Capillas C Jim 6 nez-Colmenero F | 2004 | Critical Reviews in Food Science and Nutrition2004，44，： | 1 |
| 18 | Oxidative desulfurization of diesel using promising heterogeneous tungsten catalysts and hydrogen peroxide显示文摘 | GARCíA-GUTIéRREZ J L LAREDO G C GARCíA-GUTIéRREZ P JIMNEZ-CRUZ F | 2014 | Fuel2014，138，： | 1 |
| 19 | The response of nutrient assimilation and biochemical composition of Arctic seaweeds to a nutrient input in summer显示文摘 | GordiUo F J L Aguilera J Jim~nez C | 2006 | Journal of Experimental Botany2006，57，11： | 1 |
| 20 | Growth of Dunaliella viridis Teodoresco: effect of salinity, temperature and mirogen concentration显示文摘 | Jiménez C Niell F X | 1991 | J Appl Phycol1991，3，： | 1 |
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