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| 1 | Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis显示文摘The sequence of events associated with the development of gastric cancer has been described as 'the gastric precancerous cascade'. This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori(H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the mostrelevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and mi RNAs in this context. | Manuel A Valenzuela Jimena Canales Alejandro H Corvalán Andrew FG Quest | 2015 | World Journal of Gastroenterology2015，21，45： | 33 |
| 2 | Speckle tracking echocardiography to assess regional ventricular function in patients with apical hypertrophic cardiomyopathy显示文摘AIM To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy(HCM).METHODS We prospectively assessed 20 patients(mean age 53 ± 16 years,range:18-81 years,10 were male),with apical HCM. We measured global longitudinal peak systolic strain(GLPSS) in the midwall and endocardium of the left ventricle. RESULTS The diastolic thickness of the 4 apical segments was 16.25 ± 2.75 mm. All patients had a normal global systolicfunction with a fractional shortening of 50% ± 8%. In spite of supernormal left ventricular(LV) systolic function,midwall GLPSS was decreased in all patients,more in the apical(-7.3% ±-8.8%) than in basal segments(-15.5% ±-6.93%),while endocardial GLPPS was significantly greater and reached normal values(apical:-22.8% ±-7.8%,basal:-17.9% ±-7.5%). CONCLUSION This study shows that two-dimensional strain was decreased mainly confined to the mesocardium,while endocardium myocardial deformation was preserved in HCM and allowed to identify subclinical LV dysfunction. This transmural heterogeneity in systolic strain had not been previously described in HCM and could be explained by the distribution of myofibrillar disarray in deep myocardial areas. The clinical application of this novel finding may help further understanding of the pathophysiology of HCM. | María Cristina Saccheri Tomás Francisco Cianciulli Luis Alberto Morita Ricardo JoséMéndez Martín Alejandro Beck Juan Enrique Guerra Alberto Cozzarin Luciana Jimena Puente Lorena Romina Balletti Jorge Alberto Lax | 2017 | World Journal of Cardiology2017，9，4： | 7 |
| 3 | Denervated muscle extract promotes recovery of muscle atrophy through activation of satellite cells. An experimental study显示文摘Purpose: The objective of the present study was to determine whether a denervated muscle extract(DmEx) could stimulate satellite cell response in denervated muscle.Methods: Wistar rats were divided into 4 groups: normal rats, normal rats treated with DmEx, denervated rats, and denervated rats treated with DmEx. The soleus muscles were examined using immunohistochemical techniques for proliferating cell nuclear antigen, desmin, and myogenic differentiation antigen(MyoD), and electron microscopy was used for analysis of the satellite cells.Results: The results indicate that while denervation causes activation of satellite cells, DmEx also induces myogenic differentiation of cells localized in the interstitial space and the formation of new muscle fibers. Although DmEx had a similar effect in nature on innervated and denervated muscles, this response was of greater magnitude in denervated vs. intact muscles.Conclusion: Our study shows that treatment of denervated rats with DmEx potentiates the myogenic response in atrophic denervated muscles. | Eduardo Aguera Salvador Castilla Evelio Luque Ignacio Jimena Ignacio Ruz-Caracuel Fernando Leiva-Cepas Jos Pea | 2019 | Journal of Sport and Health Science2019，8，1： | 4 |
| 4 | The prolactin family hormones regulate vascular tone through NO and prostacyclin production in isolated rat aortic rings显示文摘目的: 催乳激素家庭荷尔蒙包括生长荷尔蒙,胎盘的促黄体激素和催乳激素,它能调整 angiogenesis 经由没有并且前列腺素。然而,他们脉管的音调上的效果充分没被理解。这研究的目的是在老鼠上评估催乳激素家庭荷尔蒙的效果脉管的在 vitro 的音调。 | Carmen GONZALEZ Hector ROSAS-HERNANDEZ Brenda JURADO-MANZANO Manuel Alejandro RAMIREZ-LEE Samuel SALAZAR-GARClA Pedro Pablo MARTINEZ-CUEVAS Aida Jimena VELARDE-SALCEDO Humberto MORALES- LOREDO Ricardo ESPINOSA-TANGUMA Syed F ALl Rafael RUBIO | 2015 | Acta Pharmacologica Sinica2015，36，5： | 2 |
| 5 | Factors associated with early outcome in patients with large-vessel carotid strokes显示文摘 | Cuadrado-Godia E Jimena S Ois A | 2013 | J Neurol Neurosurg Psychiatry2013，84，3： | 1 |
| 6 | Genetic polymorphism at position-308 in the promoter region of the tumor necrosis factor (TNF) : Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population 显示文摘 | Jimena C Claudio A Perez A | 2001 | Biol Res2001，34，： | 1 |
| 7 | Mechanistic aspects of CPP-mediated intracellular drug delivery: relevance of CPP self- assembly显示文摘 | Silvia P Jimena F C Camenu L I | 2006 | Biochim Biophys Acta2006，1758，36： | 1 |
| 8 | Continuous renal replacement therapy in children after cardiac surgery显示文摘 | Maria José Santiago Jesús López-Herce Javier Urbano Maria José Solana Jimena del Castillo Amelia Sánchez Jose María Bellón | 2013 | The Journal of Thoracic and Cardiovascular Surgery2013，，2： | 1 |
| 9 | New fiber formation in rat soleus muscle following administration of denervaed muscle extract显示文摘 | Pena J Jimena I Luque E | 1995 | Neurol Sci1995，128，1： | 1 |
| 10 | Myotrophic effects of muscle extracts obtained at different intervals after denervation显示文摘 | Jimena I Pena J Luque E | 1998 | Neuropathol Appl Neurobiol1998，24，3： | 1 |
| 11 | Myotrophic effects of muscle extracts obtained at different intervals after denervation显示文摘 | Pena J Luque E | 1998 | Neuropathol Appl Neurobiol1998，24，3： | 1 |
| 12 | New fiber formation in rat soleus muscle following administration of denervaed muscle extract显示文摘 | Jimena I Luque E | 1995 | J Neurol Sci1995，128，1： | 1 |
| 13 | Factors associated with ear- ly outcome in patients with large-vessel carotid strokes 显示文摘 | Cuadrado-Godia E Jimena S Ois A | 2013 | J Neurol N eurosurg Psychiatry2013，84，3： | 1 |
| 14 | Olfactory Bulbectomy Induced Oxidative and Cell Damage in Rat: Protective Effect of Melatonin显示文摘 | Tasset I Medina F J Pe?a J Jimena I Mu?oz M Del Carmen Salcedo M Ruiz C Feijóo M Montilla P Túnez I | 2010 | Physiological Research2010，，1： | 1 |
| 15 | Interaction of modified celluloses and pectins with gluten proteins显示文摘 | Mar t a Jimena Correa Evelina Ferrer Mar f a Cristina Am 6 n | 2014 | Food Hydrocolloids2014，35，： | 1 |
| 16 | Characterising Mycobacterium tuberculosis Rv1510c protein and determining its sequences that specifically bind to two target cell lines显示文摘 | Ricardo Vera-Bravo Elizabeth Torres John J. Valbuena Marisol Ocampo Luis E. Rodríguez álvaro Puentes Javier E. García Hernando Curtidor Jimena Cortés Magnolia Vanegas Zuly J. Rivera Andrea Díaz Martha N. Calderon Manuel A. Patarroyo Manuel E. Patarroyo | 2005 | Biochemical and Biophysical Research Communications2005，，： | 1 |
| 17 | Tumor Suppression and Promotion by Autophagy显示文摘 | Yenniffer ávalos Jimena Canales Roberto Bravo-Sagua Alfredo Criollo Sergio Lavandero Andrew F. G. Quest Arkadiusz Orzechowski | 2014 | BioMed Research International2014，，： | 1 |
| 18 | PPAR-gamma agonist in treatment of diabetes: cardiovascular safety considerations显示文摘 | AAMER A JIMENA B JENNIFER R | 2012 | Cardiovasc Hematol Agents Med Chem2012，10，2： | 1 |
| 19 | Coexisting first and bilateral second branchial fistulas in a child with nonfamilial branchiootic syndrome 显示文摘 | Lapena JF Jr Jimena GL | 2013 | Ear Nose Throat J2013，92，30： | 1 |
| 20 | Continuous Renal Replacement Therapy in Children after Cardiac Surgery显示文摘 | Maria José Santiago Jesús López-Herce Javier Urbano Maria José Solana Jimena del Castillo Amelia Sánchez Jose María Bellón | 2013 | The Journal of Thoracic and Cardiovascular Surgery2013，，： | 1 |
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