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| 1 | Fault feature enhancement of gearbox in combined machining center by using adaptive cascade stochastic resonance显示文摘The difficulty to select the best system parameters restricts the engineering application of stochastic resonance(SR) . An adaptive cascade stochastic resonance(ACSR) is proposed in the present study. The proposed method introduces correlation theory into SR,and uses correlation coefficient of the input signals and noise as a weight to construct the weighted signal-to-noise ratio(WSNR) index. The influence of high frequency noise is alleviated and the signal-to-noise ratio index used in traditional SR is improved accordingly. The ACSR with WSNR can obtain optimal parameters adaptively. And it is not necessary to predict the exact frequency of the target signal. In addition,through the secondary utilization of noise,ACSR makes the signal output waveform smoother and the fluctuation period more obvious. Simulation example and engineering application of gearbox fault diagnosis demonstrate the effectiveness and feasibility of the proposed method. | LI Bing LI JiMeng HE ZhengJia | 2011 | Science China(Technological Sciences)2011，54，12： | 6 |
| 2 | Influence of herb-partitioned moxibustion at Qihai (CV6) and bilateral Tianshu (ST25) and Shangjuxu (ST37) acupoints on toll-like receptors 4 signaling pathways in patients with ulcerative colitis显示文摘OBJECTIVE: To evaluate the efficacy of herb-partitioned moxibustion(HPM) at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints in relieving symptoms and the immune regulation of HPM on the toll-like receptors 4(TLR4) signaling pathway in ulcerative colitis(UC) patients.METHODS: A randomized, single-blind study was conducted 63 patients to receive HPM or sham HPM treatment. The efficacy outcomes included scores of the Mayo, Baron, inflammatory bowel disease questionnaire(IBDQ), self-rating depression scale(SDS), self-rating anxiety scale(SAS). HE staining was used to observe the histopathological changes of the colon. The expression of inflammatory cytokines and TLR4 signaling pathway related molecules were determined by enzyme-linked immunosorbent assay and immunohistochemistry.RESULTS: Baron, SDS, SAS scores were significantly decreased in moxibustion group(P < 0.05), IBDQ score was significantly greater in the moxibustion group than in the sham moxibustion group(P < 0.05). Histopathology of mucosal biopsies showed that both two groups improved in mucosa after treatment. The expression levels of tumor necrosis factor-α, interleukin-2, interleukin-12, interferon-γ, and TLR4, lipopolysaccharide, myeloid differentiation factor 88, interleukin receptor associated kinase, tumor necrosis factor receptor associated factor 6 and nuclear factor kappa-B p65 were significantly lower in the moxibustion group than in the sham moxibustion group(P < 0.05).CONCLUSION: This study showed that HPM at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints is effective to relieve symptoms, anxiety, depression and improving life quality in UC patients,which may be related to the immune regulation of HPM on TLR4 signaling pathway. | QI Qin Hyoyoung Im LI Kunshan GU Muen WU Huangan YANG Ling HUANG Yan ZHAO Jimeng CUI Yunhua LIU Huirong WU Luyi | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 5 |
| 3 | Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer显示文摘Enolase 2(ENO2)is a key glycolytic enzyme in the metabolic process of glycolysis,but its potential function in pancreatic ductal adenocarcinoma(PDAC)is unclear.In this study,we observed a significant overexpression of ENO2 in PDAC tissues,and its expression was correlated with metastasis and poor prognosis in PDAC patients.K394 was identified as a major acetylation site in ENO2 that regulates its enzymatic activity,cell metabolism and PDAC progression.Knockdown of ENO2 suppressed tumor growth and liver metastasis in PDAC.Re-expression of wild-type(WT)ENO2,but not the K394 acetylation mimetic mutant,could reverse the decreased tumor malignancy.We further characterized histone deacetylase 3(HDAC3)and P300/CBP-associated factor(PCAF)as the potential deacetylase and acetyltransferase for ENO2,respectively.HDAC3-mediated deacetylation was shown to lead to ENO2 activation and enhancement of glycolysis.Importantly,insulin-like growth factor-1(IGF-1)was found to decrease K394 acetylation and stimulate ENO2 activity in a dose-and time-dependent manner.The PI3K/AKT/mTOR pathway facilitated the phosphorylation of HDAC3 on S424,which promoted K394 deacetylation and activation of ENO2.Linsitinib,an oral small-molecule inhibitor of IGF-1R,could inhibit IGF-1-induced ENO2 deacetylation by HDAC3 and the PI3K/AKT/mTOR pathway.Furthermore,linsitinib showed a different effect on the growth and metastasis of PDAC depending on the overexpression of WT versus K394-mutant ENO2.Our results reveal a novel mechanism by which acetylation negatively regulates ENO2 activity in the metastasis of PDAC by modulating glycolysis.Blockade of IGF-1-induced ENO2 deacetylation represents a promising strategy to prevent the development of PDAC. | Yan Zheng Chao Wu Jimeng Yang Yue Zhao Huliang Jia Min Xue Da Xu Feng Yang Deliang Fu Chaoqun Wang Beiyuan Hu Ze Zhang Tianen Li Shican Yan Xuan Wang Peter J.Nelson Christiane Bruns Lunxiu Qin Qiongzhu Dong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 4 | Comparative and phylogenomic studies on the mitochondrial genomes of Pentatomomorpha(Insecta:Hemiptera:Heteroptera)显示文摘 | Hua Jimeng Li Ming Dong Pengzhi | 2008 | BMC Genomics2008，9，： | 1 |
| 5 | Spectroscopic properties and energy transfer of Eu 2+ /Tb 3+ co-doped high silica glass显示文摘 | Yinglong Shen Qiang Zhang Jimeng Cheng Qiuchun Sheng Shuang Liu Wentao Li W. Chewpraditkul Danping Chen | 2013 | Materials Letters2013，，： | 1 |
| 6 | Effect of Tb 3+ concentration and sensitization of Ce 3+ on luminescence properties of terbium doped phosphate scintillating glass显示文摘 | Dongbing He Chunlei Yu Jimeng Cheng Shunguang Li Lili Hu | 2010 | Journal of Alloys and Compounds2010，，5： | 1 |
| 7 | Sensory nerves directly promote osteoclastogenesis by secreting peptidyl-prolyl cis-trans isomerase D(Cyp40)显示文摘Given afferent functions,sensory nerves have recently been found to exert efferent effects and directly alter organ physiology.Additionally,several studies have highlighted the indirect but crucial role of sensory nerves in the regulation of the physiological function of osteoclasts.Nonetheless,evidence regarding the direct sensory nerve efferent influence on osteoclasts is lacking.In the current study,we found that high levels of efferent signals were transported directly from the sensory nerves into osteoclasts.Furthermore,sensory hypersensitivity significantly increased osteoclastic bone resorption,and sensory neurons(SNs)directly promoted osteoclastogenesis in an in vitro coculture system.Moreover,we screened a novel neuropeptide,Cyp40,using an isobaric tag for relative and absolute quantitation(iTRAQ).We observed that Cyp40 is the efferent signal from sensory nerves,and it plays a critical role in osteoclastogenesis via the aryl hydrocarbon receptor(AhR)-Ras/Raf-p-Erk-NFATc1 pathway.These findings revealed a novel mechanism regarding the influence of sensory nerves on bone regulation,i.e.,a direct promoting effect on osteoclastogenesis by the secretion of Cyp40.Therefore,inhibiting Cyp40 could serve as a strategy to improve bone quality in osteoporosis and promote bone repair after bone injury. | Junqin Li Bin Liu Hao Wu Shuaishuai Zhang Zhuowen Liang Shuo Guo Huijie Jiang Yue Song Xing Lei Yi Gao Pengzhen Cheng Donglin Li Jimeng Wang Yang Liu Di Wang Nazhi Zhan Jing Xu Lin Wang Guozhi Xiao Liu Yang GuoXian Pei | 2023 | Bone Research2023，11，4： | 0 |
| 8 | Publisher’s Note显示文摘The editorial office decided to start from Volume 4,Issue 3 with the page range starting from 1 and henceforth the page range of all issues onwards will continue to start from 1. | Jimeng Li | 2020 | Visual Informatics2020，4，4： | 0 |
| 9 | Effect of Deep Cryogenic Treatment on Electrical Conductivity of Cu-Base Multicomponent Alloy显示文摘 | Shuqing Chen Jimeng Li Xiaojie Zhao | 2014 | 材料科学与工程(中英文B版)2014，4，2： | 0 |
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