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| 1 | Oxidative stress in neurodegenerative diseases显示文摘Reactive oxygen species are constantly produced in aerobic organisms as by-products of normal oxygen metabolism and include free radicals such as superoxide anion (O2-) and hydroxyl radical (OH-), and non-radical hydrogen peroxide (H2O2). The mitochondrial respiratory chain and enzymatic reactions by various enzymes are endogenous sources of reactive oxygen species. Exogenous reactive oxygen species -inducing stressors include ionizing radiation, ultraviolet light, and divergent oxidizing chemicals. At low concentrations, reactive oxygen species serve as an important second messenger in cell signaling; however, at higher concentrations and long-term exposure, reactive oxygen species can damage cellular macromolecules such as DNA, proteins, and lipids, which leads to necrotic and apoptotic cell death. Oxidative stress is a condition of imbalance between reactive oxygen species formation and cellular antioxidant capacity due to enhanced ROS generation and/or dysfunction of the antioxidant system. Biochemical alterations in these macromolecular components can lead to various pathological conditions and human diseases, especially neurodegenerative diseases. Neurodegenerative diseases are morphologically featured by progressive cell loss in specific vulnerable neuronal cells, often associated with cytoskeletal protein aggregates forming inclusions in neurons and/or glial cells. Deposition of abnormal aggregated proteins and disruption of metal ions homeostasis are highly associated with oxidative stress. The main aim of this review is to present as much detailed information as possible that is available on various neurodegenerative disorders and their connection with oxidative stress. A variety of therapeutic strategies designed to address these pathological processes are also described. For the future therapeutic direction, one specific pathway that involves the transcription factor nuclear factor erythroid 2-related factor 2 is receiving considerable attention. | Xueping Chen Chunyan Guo Jiming Kong | 2012 | Neural Regeneration Research2012，7，5： | 12 |
| 2 | Dynamical Mechanisms of Effects of Landslides on Long Distance Oil and Gas Pipelines显示文摘According to the investigations on the oil and gas pipelines such as the Lan-Cheng-Chong pipeline and the Southwest pipeline, there are two ways of laying pipeline: pipelines paralleling (approximately) to the main slide direction and pipelines perpendicular (approximately) to the main slide direction. If earth-retaining walls have been built for pipelines paralleling to the main slide direction, they will prevent the lands from sliding; On the contrary, without earth-retaining walls, the sharp broken rocks in the backfilling soil will scratch the safeguard of the pipeline when the landslides take place. Pipelines perpendicular to the main slide direction can be classified into four types according to the relative positions between pipelines and landslides: Pipelines over the slide planes, pipelines inside the fracture strips of slide planes, pipelines below the slide planes and pipelines behind the backsides of landslides. The different dynamical mechanisms of the process in which landslide acts against pipelines are analyzed based on whether the pipelines are equipped with fixed frusta, because the sliding resistance depends on whether and how many fixed frusta are equipped and the distance between frusta. | MA Qingwen WANG Chenghua KONG Jiming | 2006 | Wuhan University Journal of Natural Sciences2006，11，4： | 7 |
| 3 | Analysis of Rockfall and Its Impact on the Cut-and-Cover Tunnel in Dynamics显示文摘This paper presents the effect of thickness of Buffer layer on the safety of cut-and-cover tunnel under the given magnitude and height of rockfall, and the limit load of the structure. To establish calculating models of rockfall in different conditions, the dynamics of the fall down to the surface of the slope is taken into account and the exterior characteristics of the rockfall is analyzed. We have derived the formula for calculating velocity of rocks before and after collision, calculated the impact load upon the structures below and the limit load, and compared the impact force and limit load to judge the safety of the structure. Finally, the validity of models is approved by the safety evaluation of cut-and-cover tunnel in the mouth of Heshang Mountain in Nandan County. | SONG Shuzhi KONG Jiming WANG Chenghua CHENG Zefu YANG Zongji | 2006 | Wuhan University Journal of Natural Sciences2006，11，4： | 5 |
| 4 | Locomotor activity and anxiety status, but not spatial working memory,are affected in mice after brief exposure to cuprizone显示文摘Chronic long-term exposure to cuprizone causes severe brain demyelination in mice,which leads to changes in locomotion,working memory and anxiety.These findings suggest the importance of intact myelin for these behaviors.This study aimed to investigate the possible behavioral changes in mice with mild oligodendrocyte/myelin damage that parallels the white matter changes seen in the brains of patients with psychiatric disporders.We used the cuprizonetreated mouse model to test both tissue changes and behavioral functions(locomotor activity,anxiety status,and spatial working memory).The results showed that mice given cuprizone in their diet for 7 days had no significant myelin breakdown as evaluated by immunohistochemical staining for myelin basic protein,while the number of mature oligodendrocytes was reduced.The number and length of Caspr protein clusters,a structural marker of the node of Ranvier,did not change.The locomotor activity of the cuprizonetreated mice increased whereas their anxiety levels were lower than in normal controls;spatial working memory,however,did not change.These results,for the first time,link emotion-related behavior with mild white matter damage in cuprizone-treated mice. | Handi Zhang Yanbo Zhang Haiyun Xu Lingyan Wang Jinsong Zhao Junhui Wang Zhijun Zhang Qingrong Tan Jiming Kong Qingjun Huang Xin-Min Li | 2013 | Neuroscience Bulletin2013，29，5： | 4 |
| 5 | Forecast Method of Multimode System for Debris Flow Risk Assessment in Qingping Town,Sichuan Province,China显示文摘The Wenchuan Earthquake of May 12,2008 triggered large numbers of geo-hazards.The heavy rain on 13 August 2010 triggered debris flows with total volume of more than 6 million cubic meters and the debris flows destroyed 500 houses and infrastructure built after the Wenchuan Earthquake.The study area Qingping Town was located in the northwestern part of the Sichuan Basin of China,which needs the second reconstructions and the critical evaluation of debris flow.This study takes basin as the study unit and defines collapse,landslide and debris flow hazard as a geo-hazard system.A multimode system composed of principal series system and secondary parallel system were established to evaluate the hazard grade of debris flow in 138 drainage basins of Qingping Town.The evaluation result shows that 30.43% of study basins(42 basins) and 24.58% of study area,are in extremely high or high hazard grades,and both percentage of basin quantity and percentage of area in different hazard grades decrease with the increase of hazard grade.According to the geo-hazard data from the interpretation of unmanned plane image with a 0.5-m resolution and field investigation after the Wenchuan Earthquake and 8.13 Big Debris Flow,the ratio of landslides and collapses increased after the Wenchuan Earthquake and the ratios of extremely high or high hazard grades were more than moderate or low hazard grades obviously.23 geo-hazards after8.13 Big Debris Flow in Qingping town region all occurred in basins with extremely high or high hazard grades,and 9 debris flows were in basins with extremely high hazard grade.The model of multimode system for critical evaluation could forecast not only the collapse and landslide but also the debris flow precisely when the basin was taken as the study unit. | KONG Jiming | 2011 | Journal of Mountain Science2011，8，4： | 3 |
| 6 | Criterions and Measures of Route Selection of Shallowly Embedded Long-Distance Oil and Gas Pipeline in Mountain Areas显示文摘According to the engineering investigation of long-distance oil and gas pipelines, the criterions and measures of route selection are drawn as follows: the flat landform is the first choice in route alignment. The foot of mountain is the first choice when the route passes by the valley. The route should pass by but the shady and deposited slope and not in sunny and erosive slope as possible as it can. The pipeline should be vertical to contour climbing and descending the mountain except steep slope. Tunnel can be used in crossing foothill. Perpendicularly traversing the river is better than beveling; the worst choice is to put the pipeline along the river. Bypass is the best choice in karsts area . The order of route selection should be pre-choosing, investigation, optimization and adjustment. | WANG Chenghua MA Qingwen KONG Jiming CHEN Zefu LI Xiuzhen | 2006 | Wuhan University Journal of Natural Sciences2006，11，4： | 1 |
| 7 | Deformation and Development Tendency of Shiliushubao Landslide by Numerical Modeling显示文摘On the basis of analysing basic features of Shiliushubao landslide, the landslide ’ s deformation and development tendency are quantitatively studied by using FLAC 3D program. The results accord with monitoring results. The results are indicated that reservoir impounding accelerates the landslide ’ s deformation, and the variation of reservoir water level is key factor of affecting the deformation; The landslide has the characters of pull-behind movement according to the displacement of the landslide body gradually reducing from leading edge to trailing edge; Excavating and deloading slow down the landslide ’ s deformation in the certain degree. On the basis, the deformation developmental tendency of Shiliushubao landslide is predicted by the established simulating model. | LI Xiuzhen KONG Jiming XU Qiang | 2006 | Wuhan University Journal of Natural Sciences2006，11，4： | 1 |
| 8 | A new AOX homologous gene OsIM1 from rice (Oryza sativa L) with an alternative splicing mechanism under salt stress显示文摘 | Kong Jin Gong Jiming Zhang Zhigang | 2003 | Theor Appl Genet2003，107，： | 1 |
| 9 | Improvement on the performance of perovskite solar cells by doctor-blade coating under ambient condition with hole-transporting material optimization显示文摘Numerous fabrication methods have been developed for high-efficiency perovskite solar cells(PSCs). However, these are limited to spin-coating processes in a glove box and are yet to be commercialized. Therefore, there is a need to develop a controllable and scalable deposition technique that can be carried out under ambient conditions. Even though the doctor-blade coating technique has been widely used to prepare PSCs, it is yet to be applied to high-efficiency PSCs under ambient conditions(RH ~45%, RT ~25 °C). In this study, we conducted blade-coating fabrication of modified high-efficiency PSCs under such conditions. We controlled the substrate temperature to ensure phase transition of perovskite and added dimethyl sulfoxide(DMSO) to the perovskite precursor solution to delay crystallization, which can facilitate the formation of uniform perovskite films by doctor-blade coating. The as-prepared perovskite films had large crystal domains measuring up to 100 μm. Solar cells prepared from these films exhibited a current density that was enhanced from 17.22 to 19.98 m A/cm^2 and an efficiency that was increased from 10.98% to 13.83%. However, the open-circuit voltage was only 0.908 V, probably due to issues with the hole-transporting layer. Subsequently, we replaced poly(3,4-ethylenedioxythiophene) polystyrene sulfonate(PEDOT:PSS) with Ni O x as the hole-transporting material and then prepared higher-quality perovskite films by blade-coating under ambient conditions. The as-prepared perovskite films were preferably orientated and had large crystal domains measuring up to 200 μm;The open-circuit voltage of the resulting PSCs was enhanced from 0.908 to 1.123 V, while the efficiency increased from 13.83% to 15.34%. | Deng Wang Jiming Zheng Xingzhu Wang Jishu Gao Weiguang Kong Chun Cheng Baomin Xu | 2019 | Journal of Energy Chemistry2019，28，11： | 1 |
| 10 | An efficient and economical culture approach for the enrichment of purified oligodendrocyte progenitor cells显示文摘 | Jianqin Niu Lingyun Wang Shubao Liu Chengren Li Jiming Kong Hai-Ying Shen Lan Xiao | 2012 | Journal of Neuroscience Methods2012，，1： | 1 |
| 11 | Fetal cell microchimerism in the maternal mouse spinal cord显示文摘Fetal cell microchimerism refers to the persistence of fetal cells in the maternal tissues following pregnancy. It has been detected in peripheral organs and the brain, but its existence in the spinal cord has not been reported. Our aim was to detect fetal cell microchimerism in the spinal cord of maternal mice. C57BL/6 female mice were crossed with GFP transgenic male mice and sacrificed after their first or third delivery. GFP-positive cells, which were presumably from fetuses whose fathers were GFP transgenic, were detected in the spinal cord by fluorescence microscopy and immunohistochemistry. PCR was also performed to detect GFP DNA, which must come from GFP hemizygous fetuses. We found GFP-positive cells and detectable GFP DNA in most of the maternal spinal cords. Twenty percent (1/5) of the mice that were only pregnant once had detectable fetal cells, while 80% (4/5) of those that were pregnant three times had detectable fetal cells. Some fetal cells, which not only emitted green fluorescence but also expressed NeuN, were detected in the spinal cords from maternal mice. These results indicate that fetal cells migrate into the spinal cord of a maternal mouse during and/or after the gestational period, and the fetal cells may differentiate into neurons in the spinal cord. | Guohui Zhang Yunan Zhao Xin-Min Li Jiming Kong | 2014 | Neuroscience Bulletin2014，30，1： | 1 |
| 12 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 13 | Application of support vector machine with posterior probability estimates in debris flow hazard assessment 显示文摘 | Li Xiuzben Kong Jiming | 2011 | Disaster Advances2011，4，4： | 1 |
| 14 | Model Test on Deformation andFailure of Excavated Anti - dip Slope under Seismic Loading显示文摘 | Fayou A Jiming Kong Zhenqiang Ni | 2012 | Dis-aster advances2012，5，2： | 1 |
| 15 | Realizing Plain Optimization of the Thermoelectric Properties in BiCuSeO Oxide via Self-Substitution-Induced Lattice Dislocations显示文摘Seeking new strategies to tune the intrinsic defect and optimize the thermoelectric performance via no or less use of external doped elements(i.e.,plain optimization)is an important method to realize the sustainable development of thermoelectric materials.Meanwhile,creating dislocation defects in oxide systems is quite challenging because the rigid and stiff ionic/covalent bonds can hardly tolerate the large strain energy associated with dislocations.Herein,taking BiCuSe_(O) oxide as an example,the present work reports a successful construction of dense lattice dislocations in BiCuSe_(O) by self-doping of Se at the O site(i.e.,Se_(O) self-substitution),and achieves plain optimization of the thermoelectric properties with only external Pb doping.Owing to the self-substitution-induced large lattice distortion and the potential reinforcement effect by Pb doping,high-density(about 3.0×10^(14 )m^(−2))dislocations form in the grains,which enhances the scattering strength of mid-frequency phonon and results in a substantial low lattice thermal conductivity of 0.38 W m^(−1) K^(−1) at 823 K in Pb-doped BiCuSe_(O).Meanwhile,PbBi doping and Cu vacancy markedly improve the electrical conductivity while maintaining a competitively high Seebeck coefficient,thereby contributing to a highest power factor of 942μW m^(−1) K^(−2).Finally,a remarkably enhanced zT value of 1.32 is obtained at 823 K in Bi_(0.94)Pb_(0.06)Cu_(0.97)Se_(1.05)O_(0.95) with almost compositional plainification.The high-density dislocation structure reported in this work will also provide a good inspiration for the design and construction of dislocations in other oxide systems. | Rui Xu Zhiwei Chen Qizhu Li Xiaoyu Yang Han Wan Mengruizhe Kong Wei Bai Nengyuan Zhu Ruohan Wang Jiming Song Zhou Li Chong Xiao Binghui Ge | 2023 | Research2023，，4： | 0 |
| 16 | Functional regeneration of the brain:white matter matters显示文摘In the human brain,white matter makes up about 50%of the brain volume and consumes 43.8%of the brain’s total energy budget for resting potential maintenance(Harris and Attwell,2012).Composed of primarily myelinated axons,the white matter is the'highways and subways of the brain'connecting one region to another and trafficking in and | Teng Guan Jiming Kong | 2015 | Neural Regeneration Research2015，10，3： | 0 |
| 17 | Occurrence Conditions and Process Analysis on Fluidization of Valley Type Landslide:Example of the Fluidization of Landslide in Qiongshan Ravine, Danba显示文摘A big debris flow which was arosed by landslide occurrence at night on July 11, 2003 in Qiongshan Ravine, Danba, Sichuan Province. According to the research, debris flow in Qiongshan Ravine is arosed by the fluidization of landslide. It had been rained about 70 days before debris flow occurred. That made the sediments in the gully to near to saturated or saturated in water. Being affect by the steep geography, the sediments occurrence peristalsis to transform, parts of soil bodies start disintegrate. All the sediments become transforming with water inleakaging to sediments, and than foreside slope flow to gully quickly after becoming fluidization. And the sediments come into being the debris flow with the water of the gully joining. | KONG Jiming CHEN Zefu SONG Shuzhi | 2006 | Wuhan University Journal of Natural Sciences2006，11，4： | 0 |
| 18 | Utilization Alternatives and Potentiality for FGD Gypsum from Coal-Fired Power Plants显示文摘It is estimated that an installed capacity of thermal power units with desulphurization equipment will come up to 40-50 GW by the end of 2020, which affords a good opportunity for opening up and development of the market of the by-product gypsum from thermal power desulphurization. Therefore, it is necessary to research the present situation and restrictive factors in the comprehensive utilization of FGD gypsum. | Tian Hezhong Hao Jiming Zhao Zhe Kong Xiangying Yang Chao Lu Guangjie Liu Hanqiang Xu Fenggang Chu Xue(译) Liu Wenying(审校) | 2006 | Electricity2006，17，2： | 0 |
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