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| 1 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 2 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 3 | Maghemite nanoparticles and maghemite/silica nanocomposite microspheres as magnetic Fenton catalysts for the removal of water pollutants显示文摘 | Nassira Ferroudj Jimmy Nzimoto Anne Davidson Delphine Talbot Emmanuel Briot Vincent Dupuis Agnès Bée Mohamed Salah Medjram Sébastien Abramson | 2013 | Applied Catalysis B: Environmental2013，，： | 1 |
| 4 | Intrauterine infection, preterm labor, and cytokines 显示文摘 | Roberto R Offer E Jimmy E | 2005 | Gynecol Invest2005，12，7： | 1 |
| 5 | Adjusting Stacked-hedge Ratios for Stochastic Convenience Yield : A Minimum Variance Approach 显示文摘 | Jonathan M Godbey Jimmy E Hilliard | 2007 | Quantitative Finance2007，7，3： | 1 |
| 6 | Clostridium difficile toxins:Mechanism of action and role in disease显示文摘 | Daniel E V Jimmy D B | | 0，，02： | 1 |
| 7 | Venture capital, ownership structure, accounting standards and IPO under pricing显示文摘 | Julie E Jimmy J | 2010 | Journal of Economics and Business2010，62，1： | 1 |
| 8 | An approach to correlate tandem mass spectral data of peptide with amino acid sequences in a protein database显示文摘 | Jimmy K E Ashley L M John R Y | 1994 | J Am Soc Mass Spectrom1994，5，11： | 1 |
| 9 | Effects of a single dose of erythropoietin on subsequent seizure susceptibility in rats exposed to acute hypoxia at P10显示文摘 | MOHAMAD A M JIMMY A E | 2007 | Epilepsia2007，48，1： | 1 |
| 10 | Interactions between inflammation and lipid metabolism: Relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis显示文摘 | Janna A. van Diepen Jimmy F.P. Berbée Louis M. Havekes Patrick C.N. Rensen | 2013 | Atherosclerosis2013，，2： | 1 |
| 11 | Study of nanostructured WC-Co composites 显示文摘 | Jimmy W E | 1995 | International Journey of Refractory Metals &Hard Materials1995，13，5： | 1 |
| 12 | Clostridium difficile toxins: mechanism of action and role in disease 显示文摘 | Daniel E V Jimmy D B | 2005 | Clin Microbiol Rev2005，18，2： | 1 |
| 13 | Valuation of commodity futures and options under stochastic convenience yields, interest rates, and jump diffusions in the spot 显示文摘 | Jimmy E Jorge R | 1998 | Journal of Financial and Quantitative Analysis1998，，33： | 1 |
| 14 | Effi-ciency of various cloned DNA probes for detection of bovine viral diarrhea viruses 显示文摘 | Jimmy Kwang Littledikea E Travis Steve Bolinb | 1991 | Veterinary Microbiology1991，28，3： | 1 |
| 15 | Influence of temperature on water and aqueous glucose absorption spectra in the near-and mid-infrared regions at physiologically relevant temperatures显示文摘 | PETER S J JIMMY B STEFAN A E | 2003 | Applied Spectroscopy2003，57，1： | 1 |
| 16 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database显示文摘 | Jimmy K E Ashley L M John R Y | 1994 | J Am Soc Mass Spectrom1994，5，11： | 1 |
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