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您的检索式：作者名="Jincong Zhou"
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| 1 | R-loopAtlas:An integrated R-loop resource from 254 plant species sustained by a deep-learningbased tool显示文摘R-loops are chromatin structures consisting of anRNA:DNA hybrid and the other single-stranded DNA,which widely exist among genomes from bacteria to higher eukaryotes and participate in a variety of biological processes(Zhou et al.,2022).Currently,a variety of approaches to detect genome-wide R-loops have been developed,and ssDRIP-seq(single-strand DNA ligation-based library preparation from DNA:RNA hybrid immunoprecipitation,followed by sequencing)is one of the widely utilized methods(Xu et al.,2022).However,there are many limitations to genome-wide R-loop mapping based on high-throughput methods.For example,the activity of restriction enzymes for genomic DNA fragmentation. | Kuan Li Zhenzhen Wu Jincong Zhou Wei Xu Ling Li Chao Liu Wei Li Chengjun Zhang Qianwen Sun | 2023 | Molecular Plant2023，16，3： | 0 |
| 2 | R-loop:The new genome regulatory element in plants显示文摘An R-loop is a three-stranded chromatin structure that consists of a displaced single strand of DNA and an RNA:DNA hybrid duplex,which was thought to be a rare by-product of transcription.However,recent genome-wide data have shown that R-loops are widespread and pervasive in a variety of genomes,and a growing body of experimental evidence indicates that R-loops have both beneficial and harmful effects on an organism.To maximize benefit and avoid harm,organisms have evolved several means by which they tightly regulate R-loop levels.Here,we summarize our current understanding of the biogenesis and effects of R-loops,the mechanisms that regulate them,and methods of R-loop profiling,reviewing recent research advances on R-loops in plants.Furthermore,we provide perspectives on future research directions for R-loop biology in plants,which might lead to a more comprehensive understanding of R-loop functions in plant genome regulation and contribute to future agricultural improvements. | Jincong Zhou Weifeng Zhang Qianwen Sun | 2022 | Journal of Integrative Plant Biology2022，64，12： | 0 |
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