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1篇 您的检索式:作者名="JingLIU AnningLIN"
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1Role of JNK activation in apoptosis:Adouble-edged sword显示文摘JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF- κB activation, prolonged JNK activation contributes to TNF-α induced apoptosis. JNK is also essential for UV induced apoptosis. However, recent studies reveal that JNK can suppress apoptosis in IL-3-dependent hematopoietic cells via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Thus, JNK has pro- or antiapoptotic functions, depend- ing on cell type, nature of the death stimulus, duration of its activation and the activity of other signaling pathways.JingLIU AnningLIN 2005Cell Research2005,15,1:74
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