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| 1 | Concentration of circulating microparticles:a new biomarker of acute heart failure after cardiac surgery with cardiopulmonary bypass显示文摘Acute heart failure(AHF)is a severe complication after cardiac surgery with cardiopulmonary bypass(CPB).Although some AHF biomarkers have been used in clinic,they have limitations when applied in the prediction and diagnosis of AHF after cardiac surgery with CPB,and there are still no effective and specific biomarkers.We and other researchers have shown that circulating microparticles(MPs)increased in a variety of cardiovascular diseases.However,whether the concentration of circulating MPs could be a new biomarker for AHF after cardiac surgery remains unknown.Here,90 patients undergoing cardiac surgery with CPB and 45 healthy subjects were enrolled.Patients were assigned into AHF(n=14)or non-AHF(n=76)group according to the diagnosis criteria of AHF.The concentrations of circulating MPs were determined before,as well as 12 h and 3 days after operation with nanoparticle tracking analysis technique.MPs concentrations in patients before surgery were significantly higher than those of healthy subjects.Plasma levels of MPs were significantly elevated at 12 h after surgery in patients with AHF,but not in those without AHF,and the circulating MPs concentrations at 12 h after surgery were higher in AHF group compared with non-AHF group.Logistic regression analysis indicated that MPs concentration at postoperative 12 h was an independent risk factor for AHF.The area under receiver operating characteristic curve for MPs concentration at postoperative 12 h was 0.87 and the best cut-off value is 5.20×10~8 particles mL~(–1)with a sensitivity of 93%and a specificity of 70%.These data suggested that the concentration of circulating MPs might be a new biomarker for the occurrence of AHF after cardiac surgery with CPB. | Yuquan Li Haoxiang Yuan Caiyun Chen Chao Chen Jian Ma Yating Chen Yan Li Yupeng Jian Donghong Liu Zhijun Ou Jingsong Ou | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 2 | L-4F,an apohpoprotein A-1 minetic,restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells显示文摘 | Zhijtm Ou Jingsong Ou Ackerman AW | 2003 | Circulation2003，107，： | 1 |
| 3 | L-4F, an Apolipoprotein A-1 Mimetic, Restores Nitric Oxide and Superoxide Anion Balance in Low-Density Lipoprotein-Treated Endothelial Cells显示文摘 | Zhijun Ou Jingsong Ou Allan W. Ackerman Keith T. Oldham Kirkwood A. Pritchard | 2003 | Circulation: Journal of the American Heart Association2003，，11： | 1 |
| 4 | Effects of D-4F on Vasodilation and Vessel Wall Thickness in Hypercholesterolemic LDL Receptor–Null and LDL Receptor/Apolipoprotein A-I Double-Knockout Mice on Western Diet显示文摘 | Jingsong Ou Jingli Wang Hao Xu Zhijun Ou Mary G. Sorci-Thomas Deron W. Jones Paul Signorino John C. Densmore Sushma Kaul Keith T. Oldham Kirkwood A. Pritchard | 2005 | Circulation Research2005，，11： | 1 |
| 5 | L-4F, an apolipoprotein A-1 minetic, restores nitric oxide and superox- ide anion balance in low-density lipoprotein-treated endothelial cells显示文摘 | Zhijun Ou Jingsong Ou Ackerman AW | 2003 | Circulation2003，107，11： | 1 |
| 6 | L-4F,an apolipoprotein A-1 minetic,restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells显示文摘 | Zhijun Ou Jingsong Ou Ackerman AW | | 0，，11： | 1 |
| 7 | L - 4F, an apolipoprotein A- 1 minetic, restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells 显示文摘 | Zhijun Ou Jingsong Ou Allan W Ackerman | 2003 | Circulation2003，107，： | 1 |
| 8 | L - 4F, an apolipoprotein A - 1 minetic, restores nitric oxide and superoxide anion balance in low - density lipoprotein - treated endothelial cells显示文摘 | Zhijun Ou Jingsong Ou Allan W Ackerman | 2003 | Circulation2003，107，： | 1 |
| 9 | Two monitoring methods of oral anticoagulation in patients with mechanical heart valve prostheses:a Meta-analysis显示文摘Background Oral anticoagulation with warfarin has become the standard antithrombotic therapy for the patients with mechanical heart valve prothesis.The monitoring method of self-monitoring or self-management is promising to optimize the use of warfarin,but most of the previous studies have included patients with various indications of oral anticoagulant therapy other than valve procedure.This study is intended to evaluate the effects of new monitoring method compared with traditional monitoring in patients with mechanical heart valve prostheses.Methods Relevant literature finished before Dec.2010 were searched through a number of digital database.And then they are pooled by RevMan 4.2 in three fields:rate within the target range,test frequency and occurrence rate of poor events.Results Five randomised control trials with a total of 1662 patients were identified.Pooled estimates showed significant reductions in thromboembolic events(odds ratio 0.55,95%CI 0.35~0.85) and major haemorrhage(0.80,0.54~1.18).Trials of combined self-monitoring and self-adjusted therapy showed significant reductions in thromboembolic events(0.56,0.32~0.98),but not major haemorrhage(1.05,0.60~1.83).No difference was noted in minor haemorrhage and all-cause mortality.All trials reported improvements in the mean proportion of international normalisation ratios in range.Conclusions Self-monitoring can improve the quality of oral anticoagulation therapy in the patients with mechanical.Patients capable of self-monitoring and self-adjusting therapy have fewer thromboembolic events than those who self-monitor alone.However,self-monitoring is not feasible for all patients,and requires identification and education of suitable candidates heart valve prostheses. | XU Zhe,ZHANG Xi,WANG Zhiping,WU Zhongkai,OU Jingsong,YA NG Song (Division of Cardiac Surgery,The First Affiliated Hospital of Sun-Yat-Sen University,Guangzhou,Guangdong 510100, China) | 2011 | 岭南心血管病杂志2011，17，S1： | 0 |
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