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| 1 | Therapeutic effects of neuregulin-1 gene transduction in rats with myocardial infarction显示文摘 | Jian Xiao Bingong Li Zeqi Zheng Menghong Wang Jingtian Peng Yong Li Zhe Li | 2012 | Coronary Artery Disease2012，，7： | 1 |
| 2 | Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications显示文摘Hydrogen sulfide(H_(2)S)plays an important role in regulating various pathological processes such as protecting mammalian cell from harmful injuries,promoting tissue regeneration,and regulating the process of various diseases caused by physiological disorders.Studies have revealed that the physiological effects of H_(2)S are highly associated with its concentrations.At relatively low concentration,H_(2)S shows beneficial functions.However,long-time and high-dose donation of H_(2)S would inhibit regular biological process,resulting in cell dysfunction and apoptosis.To regulate the dosage of H_(2)S delivery for precision medicine,H_(2)S delivery systems with intelligent characteristics were developed and a variety of biocompatibility polymers have been utilized to establish intelligent polymeric H_(2)S delivery systems,with the abilities to specifically target the lesions,smartly respond to pathological microenvironments,as well as real-timely monitor H_(2)S delivery and lesion conditions by incorporating imaging-capable moieties.In this review,we focus on the design,preparation,and therapeutic applications of intelligent polymeric H_(2)S delivery systems in cardiovascular therapy,inflammatory therapy,tissue regenerative therapy,cancer therapy and bacteria-associated therapy.Strategies for precise H_(2)S therapies especially imaging-guided H_(2)S theranostics are highlighted.Since H_(2)S donors with stimuli-responsive characters are vital components for establishing intelligent H_(2)S delivery systems,the development of H_(2)S donors is also briefly introduced. | Fan Rong Tengjiao Wang Qian Zhou Haowei Peng Jingtian Yang Quli Fan Peng Li | 2023 | Bioactive Materials2023，，1： | 0 |
| 3 | The Effects of Signal Protein SMADs on Rat Cardiocyte Hypertrophy显示文摘 | Jun Huang Chunying Wei Jingtian Peng Zeqi Zheng Xiaoping Peng | 2005 | Journal of US-China Medical Science2005，2，4： | 0 |
| 4 | The Value of PAPP-A and MMP-9 in the Diagnosis and Outcome of ACS Patients显示文摘Objectives To investigate the value of pregnancy-associated plasma protein-A (PAPP-A) and matrix metallo proteinase-9(MMP-9) in the diagnosis and outcomes evaluation of acute coronary syndrome (ACS) patient. Methods 100 ACS patients were divided into UAP group (64 cases) and AMI group (36 cases), and 50 healthy cases served as control group. The levels of PAPP-A, MMP-9, Hs-CRP, CK-MB and cTnI were obtained. The ACS patients with normal CK-MB and cTnI concentration were followed up. During 6 months, the total rates of major cardiovascular events (MACE) were recorded. Results Compared to control group, the PAPP-A, MMP-9, Hs-CRP, CK-MB, cTnI levels of ACS patients were significantly increased (P<0.01), but the levels of PAPP-A, MMP-9 did not correlate well with CK-MB and cTnI. The ACS patients with normal CK-MB and cTnI concentration were followed up 6 months, the levels of PAPP-A, MMP-9 were significantly associated with the MACE (P<0.01). Conclusions The levels of PAPP-A, MMP-9 of ACS patients were not associated with myocardial ischemic necrosis, but could serve as predictor of unstable atherosclerotic plaque, and as valuable index for prognosis monitoring in ACS patients. | Huang Jun Xiao Jing Peng Jingtian Hao Lianman Peng Xiaoping Zhang Zhiliang | 2007 | South China Journal of Cardiology2007，8，2： | 0 |
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