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| 1 | An Adaptive RBF Neural Network Control Method for a Class of Nonlinear Systems显示文摘This paper focuses on designing an adaptive radial basis function neural network(RBFNN) control method for a class of nonlinear systems with unknown parameters and bounded disturbances. The problems raised by the unknown functions and external disturbances in the nonlinear system are overcome by RBFNN, combined with the single parameter direct adaptive control method. The novel adaptive control method is designed to reduce the amount of computations effectively.The uniform ultimate boundedness of the closed-loop system is guaranteed by the proposed controller. A coupled motor drives(CMD) system, which satisfies the structure of nonlinear system,is taken for simulation to confirm the effectiveness of the method.Simulations show that the developed adaptive controller has favorable performance on tracking desired signal and verify the stability of the closed-loop system. | Hongjun Yang Jinkun Liu | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，2： | 23 |
| 2 | Distributed disturbance-observer-based vibration control for a flexible-link manipulator with output constraints显示文摘The issue of output constraints is studied for a flexible-link manipulator in the presence of unknown spatially distributed disturbances. The manipulator can be taken as an Euler-Bernoulli beam and its dynamic is expressed by partial differential equations. On account of the uncertainty of disturbances, we present a disturbance observer to estimate infinite dimensional disturbances on the beam. The observer is proven exponentially stable. Considering the problem of output constraints in the practical engineering, we propose a novel distributed vibration controller based on the disturbance observer to fulfill the position regulation of the joint angle and suppress elastic deflections on the flexible link, while confining the regulating errors of output in a suitable scope that we can assign. The closed-loop system is demonstrated exponentially stable based on an integral-barrier Lyapunov function. Simulations validate the effectiveness of the design scheme. | YANG HongJun LIU JinKun HE Wei | 2018 | Science China(Technological Sciences)2018，61，10： | 4 |
| 3 | Protective effects of Buyinqianzheng Formula on mitochondrial morphology by PINK1/Parkin pathway in SH-SY5Y cells induced by MPP^(+)显示文摘Objective:Buyinqianzheng Formula(BYQZF)is clinically employed in traditional Chinese medicine to treat Parkinson's disease(PD)by improving mitochondrial dysfunction.However,the underlying mechanisms by which BYQZF affects mitochondrial morphology remain unknown.Therefore,we observed the effects of BYQZF on mitochondria from the perspective of the PINK1/Parkin pathway.Methods:Cell survival rates were assessed by Cell Counting Kit-8 assay.Expression levels of PINK1 and Parkin mRNA were examined by qRT-PCR.Protein expression levels of PINK1,PINK1-Ser228,Parkin,Parkin-Ser65,Drp1,and Drp1-Ser637 were examined by western blotting.PINK1,Parkin,and MitoTracker?Red CMXRos(MTR)were stained by triple-labeled immunofluorescence,and observed under laser confocal microscopy.Results:Cell survival rate,mitochondrial form factor,mean length and number of mitochondrial network branches,mitochondrial activity,m RNA expression levels of PINK1 and Parkin,and protein expression levels of PINK1,Parkin,and Drp1-Ser637 were reduced after 1-methyl-4-phenylpyridinium(MPP^(+))intervention.In contrast,Pearson's correlation coefficients between PINK1 and Parkin,and between Parkin and MTR,as well as protein expression levels of PINK1-Ser228,Parkin-Ser65,and Drp1 increased significantly after MPP^(+) intervention.Treatment with BYQZF increased cell survival rate,mitochondrial form factor,mean length and number of mitochondrial network branches,mitochondrial activity,m RNA expression levels of PINK1 and Parkin,and expression of PINK1,Parkin,and Drp1-Ser637 proteins.Pearson's correlation coefficients between PINK1 and Parkin,and between Parkin and MTR,as well as protein expression levels of PINK1-Ser228,Parkin-Ser65,and Drp1 decreased after BYQZF treatment.Conclusion:These results demonstrate that BYQZF has a protective effect on mitochondrial molecular mechanisms in the PD cell model,and the mechanism is related to the PINK1/Parkin pathway. | Haojie Ma Zhenyu Guo Cong Gai Cuicui Cheng Jinkun Zhang Yuxin Zhang Luping Yang Wandi Feng Yushan Gao Hongmei Sun | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，3： | 3 |
| 4 | Testing final closure time of the Paleo-Asian Ocean along the Solonker suture by a transition of compressional and extensional setting显示文摘The giant Central Asian Orogenic Belt is an extensive accretionary orogen,of which the Solonker suture,as a major regional suture,coincides closely with an early Permian paleobiogeographical boundary.This suture is considered to mark the location of the final closure of the Paleo-Asian Ocean between the North China Craton and the Mongolian Terrane.Although the closure time of the Paleo-Asian Ocean along the Solonker suture has generally been regarded as Late Permian-Early Triassic,uncertainty remains because of a lack of typical collisionrelated features(e.g.,high-grade regional metamorphism and well-developed fold-thrust structures)and a scarcity of outcrops.The present study reports Early Permian foliated gabbros and dikes(288-275 Ma)and Middle-Late Permian undeformed layered gabbros,strongly peraluminous granites,and I-type granites(265-254 Ma)in the Xinhure area along the northern margin of the North China Craton.The Early Permian foliated intrusions have a subduction-related geochemical signature and were derived from partial melting of lithospheric mantle modified by subduction-related melts or fluids at the active margin of the North China Craton.In contrast,the Late Permian undeformed layered gabbros and strongly peraluminous granites were derived from partial melting of lithospheric mantle and middle-upper crust,respectively,triggered by asthenospheric upwelling.Therefore,a transition from an end-compressional to an extensional environment according to a transition from collision termination to postcollision of the North China Craton and Mongolian Terrane may have occurred between 275 Ma and 262 Ma.This time span can be considered as the final closure time of the Paleo-Asian Ocean along the Solonker suture. | Haidong Zhang Jianchao Liu Jinkun Yang Jiakun Ge Jinya Wang Zhen Li | 2020 | Geoscience Frontiers2020，11，6： | 2 |
| 5 | Characteristics Analysis and Risk Assessment of Extreme Water Levels Based on 60-Year Observation Data in Xiamen, China显示文摘Extreme water levels are related to astronomical tides and storm surges.Eleven typhoon systems,which have caused extreme water level rises,were selected based on 60-yr water level data from the Xiamen tide gauge station.In these 11 typhoon systems,the astronomical tide component accounts for 71%-95%of the total water level.The Gumbel distribution of extreme water level rise was estimated,and the impact of typhoon surges on water levels during the return period was analyzed.The ex-treme tide levels caused by typhoons Herb(1996)and Dujuan(2015)are much higher than those of other typhoons and correspond to the return period of 76 yr and 71 yr,respectively.The differences of sea levels in the presence and absence of these two typhoons in the 10-100 yr return period are 5.8-11.1 cm.For the 100-yr return period,the total risks within 10,25,50,and 100 yr increase by 94.3%,85.4%,72.9%,and 54.4%,respectively,if the Herb and Dujuan are not considered.Assuming that typhoon Herb(1996)occurred during the highest astronomical tide,it will produce a water level higher than that of the 1000-yr return period.Sea level rise has an important influence on the water level return period,and the contribution of nonlinear sea level rise in the next 100 yr is estimated to be 10.34%. | MIAO Qingsheng YUE Xinyang YANG Jinkun WANG Zhifeng XU Shanshan YANG Yang CHU Siqi | 2022 | Journal of Ocean University of China2022，21，2： | 0 |
| 6 | The Change Features of the West Boundary Bifurcation Line of the North Equatorial Current in the Pacific显示文摘The equatorial Current in the North Pacific(NEC) is an upper layer westward ocean current, which flows to the west boundary of the ocean, east of the Philippines, and bifurcates into the northerly Kuroshio and the main body of the southerly Mindanao current. Thus, NEC is both the south branch of the Subtropical Circulation and the north branch of the Tropical Circulation. The junction of the two branches extends to the west boundary to connect the bifurcation points forming the bifurcation line. The position of the North Pacific Equatorial Current bifurcation line of the surface determines the exchange between and the distribution of subtropical and tropical circulations, thus affecting the local or global climate. A new identification method to track the line and the bifurcation channel was used in this study, focusing on the climatological characteristics of the western boundary of the North Equatorial Current bifurcation line. The long-term average NEC west boundary bifurcation line shifts northwards with depth. In terms of seasonal variation, the average position of the western boundary of the bifurcation line is southernmost in June and northernmost in December, while in terms of interannual variation, from spring to winter in the years when ENSO is developing, the position of the west boundary bifurcation line of NEC is relatively to the north(south) in EI Ni?o(La Ni?a) years as compared to normal years. | GUO Junru LIU Yulong SONG Jun BAO Xianwen LI Yan CHEN Shaoyang YANG Jinkun | 2015 | Journal of Ocean University of China2015，14，6： | 0 |
| 7 | A highly conserved amino acid in high molecular weight glutenin subunit 1Dy12 contributes to gluten functionality and processing quality in wheat显示文摘Bread wheat(Triticum aestivum L.)is one of the most commonly consumed staples worldwide,with widespread uses in foods such as breads,noodles,cakes,and cookies(Veraverbeke and Delcour,2002).The specific cooking properties of wheat products are mainly conferred by the gluten proteins contained in wheat grains(Delcour et al.,2012).High molecular weight glutenin subunits(HMW-GSs)are important constituents of wheat gluten proteins,largely determining gluten elasticity and processing quality(Branlard and Dardevet,1985;Payne et al.,1988). | Changfeng Yang Qian Chen Mingming Xin Zhenqi Su Jinkun Du Weilong Guo Zhaorong Hu Jie Liu Huiru Peng Zhongfu Ni Qixin Sun Yingyin Yao | 2023 | Journal of Genetics and Genomics2023，50，11： | 0 |
| 8 | Inhibitory effects of Pseudomonas aeruginosa mannose-sensitive hemagglutinin on rat C6 glioma cell proliferation显示文摘BACKGROUND: Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) parenteral injection is used as a broad-spectrum immunomodulator. It remains unclear whether PA-MSHA exhibits inhibitory effects on tumor cell growth. OBJECTIVE: To investigate inhibitory mechanisms of PA-MSHA-induced proliferation in rat C6 glioma cells in vitro. DESIGN, TIME AND SETTING: Comparative observation and in vitro experiments were performed at the Key Laboratory of Natural Medicine, Kunming Medical College, China from July 2008 to April 2009. MATERIALS: Rat C6 glioma cell line (Shanghai Institute of Cell Biology, Chinese Academy of Sciences, China) and PA-MSHA parenteral injection (Beijing Wanteer Bio-Pharmaceutical, China) were used in the present study. METHODS: Rat C6 glioma cells in logarithmic growth phase were harvested in vitro. Adherent monolayer cells were respectively treated with PA-MSHA at final colony-forming units (cfu) of 1 × 108 cfu/mL, 2 × 108 cfu/mL, 4 × 108 cfu/mL, 6 × 108 cfu/mL, and 8 × 108 cfu/mL following 24 hours of conventional culture. MAIN OUTCOME MEASURES: MTT colorimetric assay was utilized to determine the inhibitory rate of C6 glioma cells following treatment with various concentrations of PA-MSHA at different times. Cell apoptosis was detected by fluorescent microscopy following Hoechst 33258 staining. Flow cytometry was used to measure PA-MSHA effects on C6 cell cycle. RESULTS: Inhibitory rate of C6 glioma cells increased with prolonged time and increased dose. Hoechst 33258 staining revealed obvious morphological changes in apoptotic C6 glioma cells. Flow cytometry revealed hypodiploid peaks, i.e., apoptotic peak, and the apoptotic rate in cells during S-phase significantly increased with increased concentrations in the experimental groups. CONCLUSION: With in vitro experiments, PA-MSHA preparations inhibited C6 glioma cell proliferation in a time- and dose-dependent manner. These mechanisms are likely associated with cell apoptosis induction and inhibition of the S phase. | Jie Sun Jianchang Cen Qian Chang Ping Su Zhiyong Yang Jinkun Wang Peng Ding Hang Yin Zhiqiang Shen Peng Chen Dianhua Wang Ligong Bian Xiaobin Song Jun Liu | 2010 | Neural Regeneration Research2010，5，11： | 0 |
| 9 | The construction of OPA1 overexpression plasmid and the cell model显示文摘The purpose of this study is to construct OPA1 overexpression plasmid and transfected into human neuroblastoma SH-SY5Y cells to test the overexpression efficiency.Human neuroblastoma SH SY5Y cells were transfected with the OPA1 overexpression plasmid by Lipo3000 transfection reagent in liposome transduction technology.A total of 3 groups were set up:the control group,negative control group,and OPA1 overexpression model group.RT-PCR technique was used to detect the expression of OPA1 at mRNA level.In addition,Western blot technique was used to detect the expression of OPA1 at protein level.We found that the mRNA and protein expression of OPA1 were significantly increased after transfection with OPA1 overexpression plasmid.These results highlight using liposome transduction technology,the OPA1 overexpression plasmid was successfully transfected into SH-SY5Y cells by Lipo3000 and the cell model of OPA1 gene overexpression was successully established. | Ma Haojie Gai Cong Feng Wandi Cheng Cuicui Zhou Mengqi Zhang Jinkun Zhang Yuxin Yang Luping Guo Zhenyu Sun Hongmei | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 10 | Effect of Timosaponin B-Ⅱ on morphology and function of mitochondria in PD cell model显示文摘Explore the effect of Timosaponin B-Ⅱ on morphology and function of mitochondria in Parkinson's disease(PD)cell model,and lay the foundation for screening and mechanism research of anti-Parkinson's disease drugs.The PD cell model was constructed by applying MPP+to SH-SY5Y cells for 48 h,and they were treated with low,.medium and high concentrations of Timosaponin B-Ⅱ. | Zhou Mengqi Gai Cong Feng Wandi Ma Haojie Cheng Cuicui Zhao Haihong Zhang Yuxin Zhang Jinkun Yang Luping Sun Hongmei | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 11 | Electroacupuncture treatment attenuates stress-induced depressive-like behavior in rats through modulation of PNNs in the mPFC显示文摘The perineuronal nets(PNNs)are a kind of extracellular matrix structure which mainly surround parvalbumin-positive(PV^(+))GABAergic interneurons.The aim of this study is to investigate the role of PNNs in the medial prefrontal cortex(mPFC)in the antidepressant effect of electroacupuncture treatment.Adult rats underwent chronic unpredictable mild stress(CUMS)for 28 days,and electroacupuncture treatment of Baihui and Yintang acupoints was administrated from day 8 to day 28.Then we detected the depressive-and anxiety like behavior of rats,the density of PNNs,the percentage of PV^(+)neurons that surround PNNs,the expression levels of PNNs constituting proteins in the mPFC. | Zhang Yuxcin Hu Die Gai Cong Ma Haojie Cheng Cuicui Zhang Jinkun Yang Luping Sun Hongmei | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 12 | Effects of Buyang Huanwu decoction and its disassembled prescriptions on neurological function and angiogenesis in rats with ischemia stroke显示文摘This study was performed to investigate the effect and mechanism of Buyang Huanwu Decoction(BYHWD)and its disassembled prescriptions on nerve function and angiogenesis in ischemic stroke rats with Qi deficiency and blood stasis syndrome.Rats were randomly divided into six groups:Sham group,Model group,BYHWD group,Qi-tonifying group,Blood-activating group and Butyphthalide group.Rats were used to make permanent middle cerebral artery occlusion(MCAO)after 10 days of simulated intervention with compound factors of Qi deficiency and blood stasis syndrome,followed by the medicine group was administered intragastrically for a week. | Yang Luping Gai Cong Ma Haojie Cheng Cuicui Zhang Jinkun Zhang Yuxin Sun Hongmei | 2021 | 解剖学杂志2021，44，S01： | 0 |
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