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| 1 | Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1显示文摘Background:Mitochondria are dynamic organelles that constantly change their morphology through fission and fusion processes.Recently,abnormally increased mitochondrial fission has been observed in several types of can-cer.However,the functional roles of increased mitochondrial fission in lipid metabolism reprogramming in cancer cells remain unclear.This study aimed to explore the role of increased mitochondrial fission in lipid metabolism in hepa-tocellular carcinoma(HCC)cells.Methods:Lipid metabolism was determined by evaluating the changes in the expressions of core lipid metabolic enzymes and intracellular lipid content.The rate of fatty acid oxidation was evaluated by[PH]-labelled oleic acid.The mito-chondrial morphology in HCC cells was evaluated by fluorescent staining.The expression of protein was determined by real-time PCR,imnmunohistochemistry and Western blotting.Results:Activation of mitochondrial fission significantly promoted de novo fatty acid synthesis in HCC cells through upregulating the expression of lipogenic genes fatty acid synthase(FASN),acetyl-CoA carboxylasel(ACCI),and elonga-tion of very long chain fatty acid protein 6(ELOVL6),while suppressed fatty acid oxidation by downregulating carnitine palmitoyl transferase 1A(CPTIA)and acyl-CoA oxidase 1(ACOX1).Consistently,suppressed mitochondrial fission exhibited the opposite effects.Moreover,in vitro and in vivo studies revealed that mitochondrial fission-induced lipid metabolism reprogramming significantly promoted the proliferation and metastasis of HCC cells.Mechanistically,mito-chondrial fission increased the acetylation level of sterol regulatory element-binding protein 1(SREBPI)and peroxisome proliferator-activated receptor coaC-tivator 1 alpha(PGC-1a)by suppressing nicotinamide adenine dinucleotide(NAD+)/Sirtuin 1(SIRTI)signaling.The elevated SREBP1 then upregulated the expression of FASN,ACC1 and ELOVL6 in HCC cells,while PGC-1c/PPARa sup-pressed the expression of CPTIA and ACOXL Conclusions:Increased mitochondrial fission plays a crucial role in the repro-gramming of lipid metabolism in HCC cells,which provides strong evidence for the use of this process as a drug target in the treatment of this malignancy. | Dan Wu Yi Yang Yiran Hou Zifeng Zhao Ning Liang Peng Yuan Tao Yang Jinliang Xing Jibin Li | 2022 | Cancer Communications2022，42，1： | 4 |
| 2 | Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer显示文摘Colorectal cancer is one of the leading causes of cancer death worldwide.According to global genomic status,colorectal cancer can be classified into two main types:microsatellite-stable and microsatellite-instable tumors.Moreover,the two subtypes also exhibit different responses to chemotherapeutic agents through distinctive molecular mechanisms.Recently,mitochondrial DNA depletion has been shown to induce apoptotic resistance in microsatellite-instable colorectal cancer.However,the effects of altered mitochondrial DNA copy number on the progression of microsatellite-stable colorectal cancer,which accounts for the majority of colorectal cancer,remain unclear.In this study,we systematically investigated the functional role of altered mitochondrial DNA copy number in the survival and metastasis of microsatellite-stable colorectal cancer cells.Moreover,the underlying molecular mechanisms were also explored.Our results demonstrated that increased mitochondrial DNA copy number by forced mitochondrial transcription factor A expression significantly facilitated cell proliferation and inhibited apoptosis of microsatellitestable colorectal cancer cells both in vitro and in vivo.Moreover,we demonstrated that increased mitochondrial DNA copy number enhanced the metastasis of microsatellite-stable colorectal cancer cells.Mechanistically,the survival advantage conferred by increased mitochondrial DNA copy number was caused in large part by elevated mitochondrial oxidative phosphorylation.Furthermore,treatment with oligomycin significantly suppressed the survival and metastasis of microsatellite-stable colorectal cancer cells with increased mitochondrial DNA copy number.Our study provides evidence supporting a possible tumor-promoting role for mitochondrial DNA and uncovers the underlying mechanism,which suggests a potential novel therapeutic target for microsatellite-stable colorectal cancer. | Xiacheng Sun Lei Zhan Yibing Chen Gang Wang Linjie He Qian Wang Feng Zhou Fang Yang Jin Wu Yousheng Wu Jinliang Xing Xianli He Qichao Huang | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 3 |
| 3 | Comparative first-principles study of elastic constants of covalent and ionic materials with LDA,GGA,and meta-GGA functionals and the prediction of mechanical hardness显示文摘Accurate prediction of single-crystal elastic constants is critical for materials design and for understanding phase transition and elastic interactions in materials.In this work,the accuracy of elastic constants calculated with three density functional approximations has been compared,including the local density approximation(LDA),the generalized gradient approximation(GGA),and the recently developed strongly constrained and appropriately normed(SCAN)meta-GGA.The results show that SCAN and PBE describe elastic constants better than LDA.The strong correlation between the mechanical hardness and the stiffness of the softest eigenmode(SSE)has been given for above three density functionals.The correlation is capable of predicting accurately the hardness of covalent,ionic,and mixed covalent-ionic crystals,and providing us a convenient indicator for the discovery of hard or superhard materials. | XING WanDong MENG FanYan NING JinLiang SUN JianWei YU Rong | 2021 | Science China(Technological Sciences)2021，64，12： | 2 |
| 4 | Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis-associated cancer显示文摘Background:Mitochondria are key regulators in cell proliferation and apoptosis.Alterations in mitochondrial function are closely associated with inflammation and tumorigenesis.This study aimed to investigate whether mitochondrial transcription factor A(TFAM),a key regulator of mitochondrial DNA transcription and replication,is involved in the initiation and progression of colitis-associated cancer(CAC).Methods:TFAM expression was examined in tissue samples of inflammatory bowel diseases(IBD)and CAC by immunohistochemistry.Intestinal epithelial cell(IEC)-specific TFAM-knockout mice(TFAM^(△IEC))and colorectal cancer(CRC)cells with TFAM knockdown or overexpression were used to evaluate the role of TFAMin colitis and the initiation and progression ofCAC.The underlying mechanisms of TFAMwere also explored by analyzingmitochondrial respiration function and biogenesis.Results:The expression of TFAM was downregulated in active IBD and negatively associated with the disease activity.The downregulation of TFAM in IECs was induced by interleukin-6 in a signal transducer and activator of transcription 3(STAT3)/miR-23b-dependent manner.In addition,TFAM knockout impaired IECturnover to promote dextran sulfate sodium(DSS)-induced colitis inmice.Of note,TFAMknockout increased the susceptibility of mice to azoxymethane/DSSinduced CAC and TFAM overexpression protected mice from intestinal inflammation and colitis-associated tumorigenesis.By contrast,TFAM expression was upregulated in CAC tissues and contributed to cell growth.Furthermore,it was demonstrated that β-catenin induced the upregulation of TFAM through c-Myc in CRC cells.Mechanistically,TFAMpromoted the proliferation of both IECs and CRC cells by increasing mitochondrial biogenesis and activity.Conclusions:TFAM plays a dual role in the initiation and progression of CAC,providing a novel understanding of CAC pathogenesis. | Shirong Yang Xianli He Jing Zhao Dalin Wang Shanshan Guo Tian Gao Gang Wang Chao Jin Zeyu Yan Nan Wang Yongxing Wang Yilin Zhao Jinliang Xing Qichao Huang | 2021 | Cancer Communications2021，41，8： | 2 |
| 5 | GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis显示文摘 | Jinliang Xing Ronald E. Myers Xianli He Falin Qu Feng Zhou Xi Ma Terry Hyslop Guoqiang Bao Shaogui Wan Hushan Yang Zhinan Chen | 2011 | European Journal of Cancer2011，，11： | 1 |
| 6 | Potentially functional genetic variants in microRNA processing genes and risk of HBV‐related hepatocellular carcinoma显示文摘 | Li Liu Jiaze An Jibin Liu Juan Wen Xiangjun Zhai Yao Liu Shandong Pan Jie Jiang Yang Wen Zheng Liu Yixin Zhang Jianguo Chen Jinliang Xing Guozhong Ji Hongbing Shen Zhibin Hu Zhining Fan | 2013 | Mol Carcinog2013，，1： | 1 |
| 7 | Irradiation-induced telomerase activity and the risk of lung cancer: a pilot case-control study 显示文摘 | Chen Meng Gu Jian Xing Jinliang | 2007 | Cancer2007，109，6： | 1 |
| 8 | Differential induction in telomerase activity among bladder cancer patients and controls on gamma-radiation显示文摘 | Xing Jinliang Zhu Yong Zhao Hua | 2007 | Cancer Epidemiol Biomarkers Prev2007，16，3： | 1 |
| 9 | Hybrid intelligent parameter estimation based on grey case-based reasoning for laminar cooling process显示文摘 | XING Guishan DING Jinliang CHAI Tianyou | 2012 | Engineering Applications of Artificial Intelligence2012，25，2： | 1 |
| 10 | Hybrid intelligent parameter estimation based on grey case-based reasoning for laminar cooling process显示文摘 | Guishan Xing Jinliang Ding Tianyou Chai Puya Afshar Hong Wang | 2011 | Engineering Applications of Artificial Intelligence2011，，2： | 1 |
| 11 | Significant heat transfer enhancement for R123 condensation by micromembrane cylinder显示文摘Renewable energy or low grade energy utilizations need high performance of phase change heat exchangers. Suspending micromembrane cylinder in tube(called modulated heat transfer tube) increases the void fractions or vapor qualities near the tube wall to significantly enhance heat transfer. The R123 condensation heat transfer with horizontal position was investigated. The results for the bare tube and modulated heat transfer tube were tested case by case. It is found that the modulated heat transfer tube significantly enhance the condensation heat transfer, with the heat transfer enhancement factors(EF)covering the range of 1.118–2.124. The comprehensive performance evaluation criteria(PEC) had the range of0.71–1.66, with most of runs behaving PEC larger than 1.0.For the two-phase outlet conditions, the EF values are increased with increases in the vapor mass fluxes, Gxin,where G is the mass flux and xinis the inlet vapor mass quality. The EF values are inversely related to Gxinfor the subcooled liquid outlet cases. The enhanced heat transfer mechanisms are analyzed with the observed images together with the discussion of pressure and velocity distributions. | Jian Xie Feng Xing Jinliang Xu Huan Liu | 2014 | Chinese Science Bulletin2014，59，28： | 1 |
| 12 | Circulating cell-free mtDNA as a new biomarker for cancer detection and management显示文摘Cancer is a major cause of death worldwide,and was responsible for 19.29 million new cases and 9.96 million deaths in 2020 alone.The total number of patients with cancer worldwide is estimated to reach 28 million by 2040.The American Association for Cancer Research has also estimated approximately 16.2 million cancer deaths by 20401. | Fan Peng Siyuan Wang Zehui Feng Kaixiang Zhou Huanqin Zhang Xu Guo Jinliang Xing Yang Liu | 2024 | Cancer Biology & Medicine2024，21，2： | 0 |
| 13 | MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth显示文摘Mitochondrial calcium uniporter(MCU)has an important role in regulating mitochondrial calcium(Ca^(2+))homeostasis.Dysregulation of mitochondrial Ca^(2+)homeostasis has been implicated in various cancers.However,it remains unclear whether MCU regulates mitochondrial Ca^(2+)uptake to promote cell growth in colorectal cancer(CRC).Therefore,in the present study the expression of MCU in CRC tissues and its clinical significance were examined.Following which,the biological function of MCUmediated mitochondrial Ca^(2+)uptake in CRC cell growth and the underlying mechanisms were systematically evaluated using in in vitro and in vivo assays,which included western blotting,cell viability and apoptosis assays,as well as xenograft nude mice models.Our results demonstrated that MCU was markedly upregulated in CRC tissues at both the mRNA and protein levels.Upregulated MCU was associated with poor prognosis in patients with CRC.Our data reported that upregulation of MCU enhanced the mitochondrial Ca^(2+)uptake to promote mitochondrial biogenesis,which in turn facilitated CRC cell growth in vitro and in vivo.In terms of the underlying mechanism,it was identified that MCU-mediated mitochondrial Ca^(2+)uptake inhibited the phosphorylation of transcription factor A,mitochondrial(TFAM),and thus enhanced its stability to promote mitochondrial biogenesis.Furthermore,our data indicated that increased mitochondrial Ca^(2+)uptake led to increased mitochondrial production of ROS via the upregulation of mitochondrial biogenesis,which subsequently activated NF-κB signaling to accelerate CRC growth.In conclusion,the results indicated that MCU-induced mitochondrial Ca^(2+)uptake promotes mitochondrial biogenesis by suppressing phosphorylation of TFAM,thus contributing to CRC cell growth.Our findings reveal a novel mechanism underlying mitochondrial Ca^(2+)-mediated CRC cell growth and may provide a potential pharmacological target for CRC treatment. | Yang Liu Mingpeng Jin Yaya Wang Jianjun Zhu Rui Tan Jing Zhao Xiaoying Ji Chao Jin Yongfeng Jia Tingting Ren Jinliang Xing | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 14 | Advanced insulating materials contributing to“carbon neutrality”:Opportunities,issues and challenges显示文摘The vision of 2050 worldwide carbon-neutral ignites a revo-lution in all industries.Enormous innovations in both electrical power equipment and electrified transportation assets are shaping our future energy structure.Insulating materials,as the core element of energy infrastructure,are facing unprece-dented challenges that stand in the pathways to global carbon neutrality.However,researchers from both academic in-stitutions and industrial sections are working to turn the challenges into opportunities. | Chuanyang Li Yunlong Zi Yang Cao Giovanni Mazzanti Davide Fabiani Di Zhang Yunqi Xing Jinliang He | 2022 | High Voltage2022，7，4： | 0 |
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