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您的检索式：作者名="Jiujiang Zeng"
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| 1 | Microarray Analysis of Gene Expression Changes in Neuroplastin 65-Knockout Mice: Implications for Abnormal Cognition and Emotional Disorders显示文摘Neuroplastin 65(Np65) is an immunoglobulin superfamily cell adhesion molecule involved in synaptic formation and plasticity. Our recent study showed that Np65-knockout(KO) mice exhibit abnormal cognition and emotional disorders. However, the underlying mechanisms remain unclear. In this study, we found 588 differentiallyexpressed genes in Np65-KO mice by microarray analysis.RT-PCR analysis also revealed the altered expression of genes associated with development and synaptic structure,such as Cdh1, Htr3 a, and Kcnj9. In addition, the expression of Wnt-3, a Wnt protein involved in development, was decreased in Np65-KO mice as evidenced by western blotting. Surprisingly, MRI and DAPI staining showed a significant reduction in the lateral ventricular volume of Np65-KO mice. Together, these findings suggest that ablation of Np65 influences gene expression, which may contribute to abnormal brain development. These results provide clues to the mechanisms underlying the altered brain functions of Np65-deficient mice. | Huanhuan Li Jiujiang Zeng Liang Huang Dandan Wu Lifen Liu Yutong Liu Qionglan Yuan | 2018 | Neuroscience Bulletin2018，34，5： | 1 |
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