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| 1 | Genetic Architecture of Natural Variation in Rice Chlorophyll Content Revealed by a Genome-Wide Association Study显示文摘 | Quanxiu. Wang Weibo Xie Hongkun Xing Ju Yan Xiangzhou Meng Xinglei Li Xiangkui Fu Jiuyue Xu Xingming Lian Sibin Yu Yongzhong Xing Gongwei Wang | 2015 | Molecular Plant2015，8，6： | 20 |
| 2 | Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites显示文摘 | Maolu Yin Jiuyu Wang Min Wang Xinmei Li Mo Zhang Qiang Wu Yanli Wang | 2017 | Cell Research2017，27，11： | 9 |
| 3 | VNF-FG design and VNF placement for 5G mobile networks显示文摘Network function virtualization(NFV) is envisioned as one of the critical technologies in 5thGeneration(5G) mobile networks. This paper investigates the virtual network function forwarding graph(VNFFG) design and virtual network function(VNF) placement for 5G mobile networks. We first propose a two-step method composed of flow designing and flow combining for generating VNF-FGs according to network service requests. For mapping VNFs in the generated VNF-FG to physical resources, we then modify the hybrid NFV environment with introducing more types of physical nodes and mapping modes for the sake of completeness and practicality, and formulate the VNF placement optimization problem for achieving lower bandwidth consumption and lower maximum link utilization simultaneously. To resolve this problem, four genetic algorithms are proposed on the basis of the frameworks of two existing algorithms(multiple objective genetic algorithm and improved non-dominated sorting genetic algorithm). Simulation results show that Greedy-NSGA-II achieves the best performance among our four algorithms. Compared with three non-genetic algorithms(random, backtracking mapping and service chains deployment with affiliation-aware), Greedy-NSGA-II reduces 97.04%, 87.76% and88.42% of the average total bandwidth consumption, respectively, and achieves only 13.81%, 25.04% and 25.41%of the average maximum link utilization, respectively. Moreover, using our VNF-FG design method and GreedyNSGA-II together can also reduce the total bandwidth consumption remarkably. | Jiuyue CAO Yan ZHANG Wei AN Xin CHEN Jiyan SUN Yanni HAN | 2017 | Science China(Information Sciences)2017，60，4： | 8 |
| 4 | Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids显示文摘The re-emergence of Zika virus(ZIKV)in the Western Hemisphere has resulted in global public health crisis since 2015.ZIKV preferentially infects and targets human neural progenitor cells(hNPCs)and causes fetal microcephaly upon maternal infection.hNPCs not only play critical roles during fetal brain development,but also persist in adult brain throughout life.Yet the mechanism of innate antiviral immunity in hNPCs remains largely unknown.Here,we show that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs,but not in the more differentiated progenies or somatic cells.Ablation of key RNAi machinery components significantly enhances ZIKV replication in hNPCs.Furthermore,enoxacin,a broad-spectrum antibiotic that is known as an RNAi enhancer,exerts potent anti-ZIKV activity in hNPCs and other RNAi-competent cells.Strikingly,enoxacin treatment completely prevents ZIKV infection and circumvents ZIKV-induced microcephalic phenotypes in brain organoid models that recapitulate human fetal brain development.Our findings highlight the physiological importance of RNAi-mediated antiviral immunity during the early stage of human brain development,uncovering a novel strategy to combat human congenital viral infections through enhancing RNAi. | Yan-Peng Xu Yang Qiu Boya Zhang Guilai Chen Qi Chen Miao Wang Fan Mo Jiuyue Xu Jin Wu Rong-Rong Zhang Meng-Li Cheng Na-Na Zhang Bao Lyu Wen-Liang Zhu Meng-Hua Wu Qing Ye Da Zhang Jiang-Hong Man Xiao-Feng Li Jie Cui Zhiheng Xu Baoyang Hu Xi Zhou Cheng-Feng Qin | 2019 | Cell Research2019，29，4： | 8 |
| 5 | A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses显示文摘 | Jiuyu Wang Jun Ma Zhi Cheng Xu Meng Lilan You Min Wang Xinzheng Zhang Yanli Wang | 2016 | Cell Research2016，26，10： | 6 |
| 6 | Internal short circuit detection method for battery pack based on circuit topology显示文摘Internal short circuit(ISCr) is one of the major obstacles to the improvement of the battery safety. The ISCr may lead to the battery thermal runaway and is hard to be detected in the early stage. In this work, a new ISCr detection method based on the symmetrical loop circuit topology(SLCT) is introduced. The SLCT ensures that every battery has the same priority in the circuit and every battery will contribute the same amount of short-circuit current to the ISCr once the ISCr happens. The ISCr battery could be identified by the combination of the ratio of the short-circuit currents and the sign of the short-circuit currents. The recursive least square method is adopted for the real-time application and the optimized ammeters allocation is derived from the mathematic deduction. The battery pack based on the individual DP(dual polarization) battery model is established to verify the ISCr detection method. The 1–1000 Ω s ISCr(the early stage ISCr) can be effectively detected within 1–125 s. The SLCT provides the possibility of new battery pack designs and new battery management methods. The proposed ISCr detection method shows excellent effectiveness and efficiency on the identification of the ISCr battery in the early stage. | ZHANG MingXuan DU JiuYu LIU LiShuo SIEGEL Jason LU LanGuang HE XiangMing OUYANG MingGao | 2018 | Science China(Technological Sciences)2018，61，10： | 6 |
| 7 | SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells显示文摘Dear Editor,Coronaviruses (Co Vs) are large enveloped non-segmented positive-strand RNA viruses that broadly distribute among humans and other animal species, including bats, mice and birds. SARS-Co V-2 infections can cause diseases, named the 2019 novel coronavirus disease (COVID-19). The symptoms of COVID-19 range from mild symptoms to severe respiratory syndromes, including pneumonia, and even death(Chen et al., 2020b;Jiang and Shi, 2020;Xia et al., 2020). | Jingfang Mu Jiuyue Xu Leike Zhang Ting Shu Di Wu Muhan Huang Yujie Ren Xufang Li Qing Geng Yi Xu Yang Qiu Xi Zhou | 2020 | Science China(Life Sciences)2020，63，9： | 5 |
| 8 | Progress review of US-China joint research on advanced technologies for plug-in electric vehicles显示文摘The United States and China are the world's largest automobile markets and oil consumers, and both face a severe challenge to conserve energy and reduce tailpipe emissions. Thus, both countries urgently need to transform conventional internal combustion engines to electrified powertrains. Targeting the advanced core technologies of plug-in electric vehicles(PEVs), a joint research collaboration between China and the US, called the 'Clean Vehicle Consortium'(CVC), was set up in 2010. Six years of collaboration on PEV technologies has resulted in significant progress in three technical areas. Based on CVC publications,we review herein the progress made by the CVC research efforts on three key advanced PEV technologies. This includes the development of a safe battery with an energy density of 260 W h kg^(-1) and a systematic method for designing safe traction battery systems. Thus, a breakthrough in high power density and efficient traction motor systems has occurred. In addition to discussing advanced electric-drive powertrains, we also discuss global energy management strategies that aim to improve PEV energy efficiency. This discussion covers scientific and comprehensive analysis methods to analyze energy systems, which include costbenefit analyses of plug-in hybrid electric vehicles, life-cycle assessments for evaluating vehicle emissions, and PEV-ownership projections. | OUYANG MingGao DU JiuYu PENG Huei WANG HeWu FENG XuNing SONG ZiYou | 2018 | Science China(Technological Sciences)2018，61，10： | 5 |
| 9 | A novel true triaxial test system for microwave-induced fracturing of hard rocks显示文摘This study introduces a test system for microwave-induced fracturing of hard rocks under true triaxial stress.The test system comprises a true triaxial stress loading system,an open-ended microwaveinduced fracturing system,a data acquisition system,an acoustic emission(AE)monitoring system,and an auxiliary specimen loading system.Microwave-induced surface and borehole fracturing tests under true triaxial stress were fulfilled for the first time,which overcomes the problem of microwave leakage in the coupling loading of true triaxial stress and microwave.By developing the dynamic monitoring system,the thermal response and fracture evolution were obtained during microwave irradiation.The monitoring system includes the infrared thermometry technique for monitoring rock surface temperature,the distributed optic fiber sensing technique for monitoring temperature in borehole in rock,the AE technique and two-dimensional digital speckle correlation technique for monitoring the evolution of thermal damage and the rock fracturing process.To validate the advantages of the test system and investigate the characteristics of microwave-induced fracturing of hard rocks,the study demonstrates the experimental methods and results for microwave-induced surface and borehole fracturing under true triaxial stress.The results show that thermal cracking presented intermittent characteristics(calm eactiveecalm)during microwave-induced surface and borehole fracturing of basalt.In addition,true triaxial stress can inhibit the development and distribution of thermal cracks during microwave-induced surface fracturing.When microwave-induced borehole fracturing occurs,it promotes the distribution of thermal cracks in rock,but inhibits the width of cracks.The results also prove the reliability of the test system. | Xia-Ting Feng Jiuyu Zhang Chengxiang Yang Jun Tian Feng Lin Shiping Li Xiangxin Su | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，5： | 5 |
| 10 | Characteristics of biomass ashes from different materials and their ameliorative effects on acid soils显示文摘The chemical characteristics,element contents,mineral compositions,and the ameliorative effects on acid soils of five biomass ashes from different materials were analyzed. The chemical properties of the ashes varied depending on the source biomass material. An increase in the concrete shuttering contents in the biomass materials led to higher alkalinity,and higher Ca and Mg levels in biomass ashes,which made them particularly good at ameliorating effects on soil acidity. However,heavy metal contents,such as Cr,Cu,and Zn in the ashes,were relatively high. The incorporation of all ashes increased soil p H,exchangeable base cations,and available phosphorus,but decreased soil exchangeable acidity. The application of the ashes from biomass materials with a high concrete shuttering content increased the soil available heavy metal contents. Therefore,the biomass ashes from wood and crop residues with low concrete contents were the better acid soil amendments. | Renyong Shi Jiuyu Li Jun Jiang Khalid Mehmood Yuan Liu Renkou Xu Wei Qian | 2017 | Journal of Environmental Sciences2017，29，5： | 5 |
| 11 | Hepatitis C Virus NS2 Protein Suppresses RNA Interference in Cells显示文摘RNAi interference(RNAi)is an evolutionarily conserved post-transcriptional gene silencing mechanism and has been well recognized as an important antiviral immunity in eukaryotes.Numerous viruses have been shown to encode viral suppressors of RNAi(VSRs)to antagonize antiviral RNAi.Hepatitis C virus(HCV)is a medically important human pathogen that causes acute and chronic hepatitis.In this study,we screened all the nonstructural proteins of HCV and found that HCV NS2 could suppress RNAi induced either by small hairpin RNAs(shRNAs)or small interfering RNAs(siRNAs)in mammalian cells.Moreover,we demonstrated that NS2 could suppress RNAi via its direct interaction with doublestranded RNAs(dsRNAs)and siRNAs,and further identified that the cysteine 184 of NS2 is required for the RNAi suppression activity through a serial of point mutation analyses.Together,our findings uncovered that HCV NS2 can act as a VSR in vitro,thereby providing novel insights into the life cycle and virus-host interactions of HCV. | Hui Zhou Qi Qian Ting Shu Jiuyue Xu Jing Kong Jingfang Mu Yang Qiu Xi Zhou | 2020 | Virologica Sinica2020，35，4： | 3 |
| 12 | Proteomics Profiling of Host Cell Response via Protein Expression and Phosphorylation upon Dengue Virus Infection显示文摘Dengue virus(DENV)infection is a worldwide public health threat.To date,the knowledge about the pathogenesis and progression of DENV infection is still limited.Combining global profiling based on proteomic analysis together with functional verification analysis is a powerful strategy to investigate the interplay between the virus and host cells.In the present study,quantitative proteomics has been applied to evaluate host responses(as indicated by altered proteins and modifications)in human cells(using K562 cell line)upon DENV-2 infection,as DENV-2 spreads most widely among all DENV serotypes.Comparative analysis was performed to define differentially expressed proteins in the infected cells compared to the mock-control,and it revealed critical pathogen-induced changes covering a broad spectrum of host cellular compartments and processes.We also discovered more dramatic changes(>20%,160 regulated phosphoproteins)in protein phosphorylation compared to protein expression(14%,321 regulated proteins).Most of these proteins/phosphoproteins were involved in transcription regulation,RNA splicing and processing,immune system,cellular response to stimulus,and macromolecule biosynthesis.Western blot analysis was also performed to confirm the proteomic data.Potential roles of these altered proteins were discussed.The present study provides valuable large-scale protein-related information for elucidating the functional emphasis of host cell proteins and their post-translational modifications in virus infection,and also provides insight and protein evidence for understanding the general pathogenesis and pathology of DENV. | Meng Miao Fei Yu Danya Wang Yongjia Tong Liuting Yang Jiuyue Xu Yang Qiu Xi Zhou Xiaolu Zhao | 2019 | Virologica Sinica2019，34，5： | 2 |
| 13 | Mechanism of aluminum release from variable charge soils induced by low-molecular-weight organic acids: Kinetic study显示文摘 | Jiuyu Li Renkou Xu Diwakar Tiwari Guoliang Ji | 2006 | Geochimica et Cosmochimica Acta2006，，11： | 1 |
| 14 | Spant- io-temporal traffic scene modeling for object motion detec- tion显示文摘 | HAO JIUYUE LI CHAO KIM ZUWHAN | 2013 | IEEE Trans on Intelligent Transportation Sys- tems2013，14，1： | 1 |
| 15 | Adsorp- tion of Cu(II) by biochars generated from three crop straws 显示文摘 | Tong Xuejiao Li Jiuyu Yuan Jinhua | 2011 | Chem Eng J2011，172，23： | 1 |
| 16 | Adsorption of Cu(Ⅱ) by biochars generated from three crop straws显示文摘 | TONG Xuejiao LI Jiuyu YUAN Jinhua | 2011 | Chemical Engineering Journal2011，172，23： | 1 |
| 17 | Adsorption of Cu(II ) by biochars generated from three crop straws 显示文摘 | TONG Xuejiao LI Jiuyu YUAN Jinhua | 2011 | ChemicalEngineering Journal2011，172，23： | 1 |
| 18 | Crystal structure of Cas1 in complex with branched DNA显示文摘Cas1 is a key component of the CRISPR adaptation complex,which captures and integrates foreign DNA into the CRISPR array,resulting in the generation of new spacers.We have determined crystal structures of Thermus thermophilus Cas1 involved in new spacer acquisition both in complex with branched DNA and in the free state.Cas1 forms an asymmetric dimer without DNA.Conversely,two asymmetrical dimers bound to two branched DNAs result in the formation of a DNA-mediated tetramer,dimer of structurally asymmetrical dimers,in which the two subunits markedly present different conformations.In the DNA binding complex,the N-terminal domain adopts different orientations with respect to the C-terminal domain in the two monomers that form the dimer.Substrate binding triggers a conformational change in the loop 164–177 segment.This loop is also involved in the 3′fork arm and 5′fork arm strand recognition in monomer A and B,respectively.This study provides important insights into the molecular mechanism of new spacer adaptation. | Jing Yang Jiazhi Li Jiuyu Wang Gang Sheng Min Wang Hongtu Zhao Yanhua Yang Yanli Wang | 2020 | Science China(Life Sciences)2020，63，4： | 1 |
| 19 | Characterization of the chemical fungicides-responsive and bacterial pathogen-preventing Bacillus licheniformis in rice spikelet显示文摘Seed-borne bacterial pathogens cause severe yield loss and biotoxin contamination in rice,leading to increasing concern on the global food supply and environmental safety.Plant native microbes play an important role in defending against diseases,but their actions are often influ-enced by the chemical fungicides applied in the field.Here,Bacillus licheniformis mmj was isolated from rice spikelet,which uniquely showed not only fungicide-responsiveness but also broad-spectrum antimicrobial activity against major rice bacterial pathogens including Xanthomonas oryzae pv.oryzae,Burkholderia plantari and Burkholderia glumae.To understand the hallmark underlying the environmental adaptation and anti-microbial activity of B.licheniformis mmj,the genome sequence was determined by SMRT and subjected to bioinformatics analysis.Genome sequence analysis enabled the identification of a set of antimicrobial-resistance and antibacterial activity genes together with an array of harsh environment-adaptive genes.Moreover,B.licheniformis mmj metabolites were analyzed with gas chromatography coupled to triple quadrupole mass spectrometry,and the volatile components that were linked with the antimicrobial activity were preliminarily profiled.Collectively,the present findings reveal the genomic and metabolic landscapes underlying fungicide-responsive B.licheniformis,which offers a new opportunity to design harsh environment-adaptive biopesticides to cope with prevalent bacterial phytopathogens. | Chengfang Zhan Mengchen Wu Hongda Fang Xiaoyu Liu Jiuyue Pan Xiaoyan Fan Mengcen Wang Haruna Matsumoto | 2023 | Food Quality and Safety2023，7，2： | 1 |
| 20 | An ultra-fast charging strategy for lithium-ion battery at low temperature without lithium plating显示文摘Conventional charging methods for lithium-ion battery(LIB)are challenged with vital problems at low temperatures:risk of lithium(Li)plating and low charging speed.This study proposes a fast-charging strategy without Li plating to achieve high-rate charging at low temperatures with bidirectional chargers.The strategy combines the pulsed-heating method and the optimal charging method via precise control of the battery states.A thermo-electric coupled model is developed based on the pseudo-twodimensional(P2D)electrochemical model to derive charging performances.Two current maps of pulsed heating and charging are generated to realize real-time control.Therefore,our proposed strategy achieves a 3 C equivalent rate at 0℃ and 1.5 C at-10℃ without Li plating,which is 10–30 times faster than the traditional methods.The entropy method is employed to balance the charging speed and the energy efficiency,and the charging performance is further enhanced.For practical application,the power limitation of the charger is considered,and a 2.4 C equivalent rate is achieved at 0℃ with a 250 kW maximum power output.This novel strategy significantly expands LIB usage boundary,and increases charging speed and battery safety. | Yudi Qin Pengyu Zuo Xiaoru Chen Wenjing Yuan Rong Huang Xiaokan Yang Jiuyu Du Languang Lu Xuebing Han Minggao Ouyang | 2022 | Journal of Energy Chemistry2022，31，9： | 1 |
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