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| 1 | Thin films as an emerging platform for drug delivery显示文摘Pharmaceutical scientists throughout the world are trying to explore thin films as a novel drug delivery tool. Thin films have been identified as an alternative approach to conventional dosage forms. The thin films are considered to be convenient to swallow, selfadministrable, and fast dissolving dosage form, all of which make it as a versatile platform for drug delivery. This delivery system has been used for both systemic and local action via several routes such as oral, buccal, sublingual, ocular, and transdermal routes. The design of efficient thin films requires a comprehensive knowledge of the pharmacological and pharmaceutical properties of drugs and polymers along with an appropriate selection of manufacturing processes. Therefore, the aim of this review is to provide an overview of the critical factors affecting the formulation of thin films, including the physico-chemical properties of polymers and drugs, anatomical and physiological constraints, as well as the characterization methods and quality specifications to circumvent the difficulties associated with formulation design. It also highlights the recent trends and perspectives to develop thin film products by various companies. | Sandeep Karki Hyeongmin Kim Seon-Jeong Na Dohyun Shin Kanghee Joa Jaehwi Lee | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 6 |
| 2 | Mercury in sediments and vegetation in a moderately contaminated salt marsh (Tagus Estuary, Portugal)显示文摘Depth variations of total mercury (Hg) and methylmercury (MeHg) concentrations were studied in cores from non-colonized sediments, sediments colonized by Halimione portulacoides, Sarcocornia fruticosa and Spartina maritima and belowground biomass, in a moderately contaminated salt marsh (Tagus Estuary, Portugal). Concentrations in belowground biomass exceeded up to 3 (Hg) and 15 (MeHg) times the levels in sediments, and up to 198 (Hg) and 308 (MeHg) times those found in aboveground parts. Methylmercury in colonized sediments reached 3% of the total Hg, 50 times above the maximum values found in non-colonized sediments. The absence of correlations between total Hg concentrations in sediments and the corresponding MeHg levels suggested that methylation was only dependent on the environmental and microbiological factors. The analysis of belowground biomass at high-depth resolution (2 cm) provided evidence that Hg and MeHg were actively absorbed from sediments, with higher enrichment factors at layers where higher microbial activity was probably occurring. The results obtained in this study indicated that the biotransformation of Hg to the toxic MeHg could increase the toxicity of plant-colonized sediments. | Joao Canário Carlos Vale Laurier Poissant Marta Nogueira Martin Pilote Vasco Branco | 2010 | Journal of Environmental Sciences2010，22，8： | 4 |
| 3 | A peer-to-peer zone-based two-level link state routing for mobile ad hoc networks显示文摘 | Joa Ng M Lu I T | 1999 | IEEE Journal on Selected Areas in Communications1999，17，8： | 1 |
| 4 | Chemopreventive properties of the ethanol extract of Chinese licorice (Glycyrrhiza uralensis) root:induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells显示文摘 | Eun-Hye Joa Sung-Hoon Kim | 2005 | Cancer Letters2005，230，： | 1 |
| 5 | WebTurning:Teleoperation of a CNC turning center through the Internet显示文摘 | Alberto Jose ' A' lvares Joa~o Carlos Esp' ndola Ferreira | 2006 | Journal of Materials Procesing Technology2006，，179： | 1 |
| 6 | Phenylpropanoid ester from Zingiber officinale and their inhibitory effects on the production of nitric oxide显示文摘 | Seong Su Hong Joa Sub Oh | 2012 | Archives of Pharmacal Research2012，，： | 1 |
| 7 | Autonomic dysreflexia- induced reversible posterior leukoencephalopathy syndrome in patients with spinal cord injury: two case reports 显示文摘 | Joa KL Shin YI Suh H | 2013 | J Spinal Cord Med2013，36，3： | 1 |
| 8 | A one year study of the macular pigment:the effect of 140 days of a lutein supplement显示文摘 | Landrum J T Bone R A Joa H | 1997 | Experimental Eye Research1997，65，1： | 1 |
| 9 | Diabetes self-efficacy and self-care behaviour of Chinese patients living in Shanghai显示文摘 | Wang JOa Tak-Ying Shiu A | 2004 | J Clin Nurs2004，13，6： | 1 |
| 10 | Some peculiarities in the specific adsorption of phosphate ions on hematite and γ -Al2O3 as reflected by radiotracer studies 显示文摘 | Horanyi G Joa P | 2002 | Journal of Colloid and Interface Science2002，247，1： | 1 |
| 11 | Prevalence of cardiovascular disorders and risk factors in two 75-year-old birth cohorts examined in 1976--1977 and 2005--2006显示文摘 | Zhi X Joas E Waern M | 2013 | Aging Clin Exp Res2013，25，4： | 1 |
| 12 | Autonomie dysreflexia-in- duced reversible posterior leukoencephalopathy syndrome in patients with spinal cord injury: two case reports显示文摘 | Joa KL Shin YI Suh H | 2013 | J Spinal Cord Med2013，36，3： | 1 |
| 13 | Cryopreservation of mature monocyte-derived human dendritic cells for vaccination:influence on phenotype and functional显示文摘 | Jorg Westermann Ida J Korner Joa chim Kopp | 2003 | Cancer Immunol Immunother2003，52，3： | 1 |
| 14 | Youth risk behavior surveillance,United States,2003显示文摘 | JoA Laura K Steve K | 2004 | J School Health2004，74，8： | 1 |
| 15 | Integration and Competition in the European Financial Markets显示文摘 | Juan Fernandez De Guevara Joa QuinM audos Franciscoperez | 2007 | Journal of International Money and Finance2007，26，1： | 1 |
| 16 | Kinetic sofwater absorbency in AA/AMPS copolymers 显示文摘 | Fatima R Joa B Miguel C | 2002 | Pol- ymer2002，43，： | 1 |
| 17 | Leaf: fruits ratio and irrigation supply affect seasonal changes in minerals, organic acids and sugars of mango fruits 显示文摘 | Lechaudel M Joas J Caro Y | 2005 | J Sci Food Agric2005，，85： | 1 |
| 18 | The frequency of CLA1 CD81 T cells in the blood of psoriasis patients correlates closely with the severity of their disease显示文摘 | SIGMUNDSDOATTIR H GUDJOANSSON JE JOA NSDOATTIR I | 2001 | Clin Exp Immunol2001，126，： | 1 |
| 19 | Prevalence of cardiovascular disorders and risk factors in two 75-year-old birth cohorts examined in 1976- 1977 and 2005-2006显示文摘 | Zhi X Joas E Waern M | 2013 | Aging Clin Exp Res2013，25，4： | 1 |
| 20 | A one year study of the macular pigment: the effect of 140 days of a lutein supplement 显示文摘 | Landrum JT Bone RA Joa H Kilburn MD Moore LL Spraque KE | 1997 | Exp Eye Res1997，65，1： | 1 |
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