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| 1 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 2 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 3 | Soil-air exchange of nitric oxide: An overview of processes, environmental factors, and modeling studies显示文摘 | J?rg Ludwig Franz X. Meixner Bernhard Vogel Jochen F?rstner | 2001 | Biogeochemistry2001，，3： | 2 |
| 4 | Muller,Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in sediments from Hong Kong显示文摘 | Jochen F | 2002 | Marine Pollution Bulletin2002，45，： | 1 |
| 5 | Mass flow during unloading of agricultural bulk materials from silos depending on particle form, flow properties and geometry of the discharge opening显示文摘 | Jochen Mellmann Thomas Hoffmann Christian Fürll | 2014 | Powder Technology2014，，： | 1 |
| 6 | Probabilistic failure assessment of ferritic steels using the master curve approach including constraint effects显示文摘 | Jorg H Jochen H Valérie F | 2007 | Engineering Fracture Mechanics2007，74，： | 1 |
| 7 | The influence of bile salts and mixed micelles on the pharmacokinetics of quinine in rabbits显示文摘 | Bertram F Jochen G | 2005 | European Journal of Pharmaceutics and Biopharmaceutics2005，60，1： | 1 |
| 8 | Hindsight Bias: On Being Wise After the Event显示文摘 | Hartmut B Jochen M Rudiger F P | 2007 | Social Cognition2007，，1： | 1 |
| 9 | Genome-wide investigation of gene–environment interactions in colorectal cancer显示文摘 | Sabine Siegert Jochen Hampe Clemens Schafmayer Witigo Sch?nfels Jan-Hendrik Egberts Asta F?rsti Bowang Chen Jesús Lascorz Kari Hemminki Andre Franke Michael Nothnagel Ute N?thlings Michael Krawczak | 2013 | Human Genetics2013，，2： | 1 |
| 10 | Standarodized MRI stroke protocol comparison with CT in hyperacute intracerebral hemorrhage显示文摘 | PETER D S OLAV J JOCHEN B F | 1999 | Stroke1999，30，： | 1 |
| 11 | Monitoring PAHs in the Brisbane River and Moreton Bay, Australia, using semipermeable membrane devices and EROD activity in yellowfin bream, Acanthopagrus australis显示文摘 | Shaw M Tibbetts I R Jochen M F | 2004 | Chemosphere2004，56，： | 1 |
| 12 | Development of fluid eonduits in the auriferous shear zone of the Hutti Gold Mine,India: evidence for spatially and temporally heterogeneous fluid flow显示文摘 | JOCHEN K AMANDA R MICHAEL M F | 2004 | Tectonophysics2004，378，12： | 1 |
| 13 | Imaging-based decision making in thrombolytic therapy for isehemic stroke: present status显示文摘 | Peter D S Jochen B F Werner H | 2003 | Stroke2003，34，2： | 1 |
| 14 | Diagnostic potential of breath analysis-focus on volatile organic compounds 显示文摘 | Wolfram M Jochen K Gabriele F E | 2004 | Clin Chim Acta2004，347，1： | 1 |
| 15 | Tau-mediated cytotoxicity in a pseudohyper-phosphorylation model of Alzheimer's disease显示文摘 | Thomas F Jochen E Roland B | 2002 | J Neuroscience2002，22，22： | 1 |
| 16 | Monitoring PAHs in the Brisbane River and Moreton Bay,Australia,using semipermeable membrane devices and EROD activity in Yellowfin Bream,Acanthopagrus Australis显示文摘 | Melanie S Ian R T Jochen F M | 2004 | Chemosphere2004，56，： | 1 |
| 17 | PAHs, PCDD/Fs, PCBs and HCB in leaves from Brisbane, Australia显示文摘 | Jochen F Müller Darryl W Hawker Michael S McLachlan Des W Connell | 2001 | Chemosphere2001，，4： | 1 |
| 18 | Time dependent deformations during tunnelling and stability of tunnel faces in fine-grained soils under groundwater显示文摘 | ROGER H JOCHEN F NORBERT V | 2008 | Acta Geotechnica2008，3，4： | 1 |
| 19 | Soil-air exchange of nitric oxide: An overview of processes, environmental factors, and modeling studies显示文摘 | J?rg Ludwig Franz X. Meixner Bernhard Vogel Jochen F?rstner | 2001 | Biogeochemistry2001，，3： | 1 |
| 20 | Muller, Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in sediments from Hong Kong显示文摘 | Jochen F | 2002 | Marine Pollution Bulletin2002，45，： | 1 |
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