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1篇 您的检索式：作者名="John AKessler"

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		题名	作者	年代	出处	被引量
	1	Inhibition of immune checkpoints prevents injury-induced heterotopic ossification显示文摘Heterotopic ossification(HO),true bone formation in soft tissue,is closely associated with abnormal injury/immune responses.We hypothesized that a key underlying mechanism of HO might be injury-induced dysregulation of immune checkpoint proteins(ICs).We found that the earliest stages of HO are characterized by enhanced infiltration of polarized macrophages into sites of minor injuries in an animal model of HO.The non-specific immune suppressants,Rapamycin and Ebselen,prevented HO providing evidence of the central role of the immune responses.We examined the expression pattern of ICs and found that they are dysregulated in HO lesions.More importantly,loss of function of inhibitory ICs(including PD1,PD-L1,and CD152)markedly inhibited HO,whereas loss of function of stimulatory ICs(including CD40L and OX-40L)facilitated HO.These findings suggest that IC inhibitors may provide a therapeutic approach to prevent or limit the extent of HO.	Chen Kan Jiazhao Yang Ding Na Yuanhong Xu Baixia Yang Haodong Zhao Huadong Lu Yuyun Li Keqin Zhang Tammy LMcGuire John AKessler Lixin Kan	2019	Bone Research2019，7，4：	1

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