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| 1 | Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis显示文摘AIM: To evaluate the effect of orally administeredplecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine models.METHODS: The cyclic guanosine monophosphate(cG MP) stimulatory potency of plecanatide and dolcanatide was measured using a human colon carcinoma T84 cellbased assay. For animal studies all test agents were formulated in phosphate buffered saline. Sulfasalazine or 5-amino salicylic acid(5-ASA) served as positive controls. Effect of oral treatment with test agents on amelioration of acute colitis induced either by dextran sulfate sodium(DSS) in drinking water or by rectal instillation of trinitrobenzene sulfonic(TNBS) acid, was examined in BALB/c and/or BDF1 mice. Additionally, the effect of orally administered plecanatide on the spontaneous colitis in T-cell receptor alpha knockout(TCRα-/-) mice was also examined. Amelioration of colitis was assessed by monitoring severity of colitis, disease activity index and by histopathology. Frozen colon tissues were used to measure myeloperoxidase activity.RESULTS: Plecanatide and dolcanatide are structurally related analogs of uroguanylin, which is an endogenous ligand of guanylate cyclase-C(GC-C). As expected from the agonists of GC-C, both plecanatide and dolcanatide exhibited potent cG MP-stimulatory activity in T84 cells. Once-daily treatment by oral gavage with either of these analogs(0.05-0.5 mg/kg) ameliorated colitis in both DSS and TNBS-induced models of acute colitis, as assessed by body weight, reduction in colitis severity(P < 0.05) and disease activity index(P < 0.05). Amelioration of colitis by either of the drug candidates was comparable to that achieved by orally administered sulfasalazine or 5-ASA. Plecanatide also effectively ameliorated colitis in TCRα-/- mice, a model of spontaneous colitis. As dolcanatide exhibited higher resistance to proteolysis in simulated gastric and intestinal juices, it was selected for further studies. CONCLUSION: This is the first-ever study reporting the therapeutic utility of GC-C agonists as a new class of orally delivered and mucosally active drug candidates for the treatment of inflammatory bowel diseases. | Kunwar Shailubhai Vaseem Palejwala Krishna Priya Arjunan Sayali Saykhedkar Bradley Nefsky John A Foss Stephen Comiskey Gary S Jacob Scott E Plevy | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 5 |
| 2 | Pushing the boundaries of diode-pumped solid-state lasers for high-energy applications显示文摘We report on the successful demonstration of a 150 J nanosecond pulsed cryogenic gas cooled,diode-pumped multi-slab Yb:YAG laser operating at 1 Hz.To the best of our knowledge,this is the highest energy ever recorded for a diodepumped laser system. | Saumyabrata Banerjee Paul Mason Jonathan Phillips Jodie Smith Thomas Butcher Jacob Spear Mariastefania De Vido Gary Quinn Danielle Clarke Klaus Ertel Cristina Hernez-Gomez Chris Edwards John Collier | 2020 | High Power Laser Science and Engineering2020，8，2： | 4 |
| 3 | 2024 Adult Compendium of Physical Activities:A third update of the energy costs of human activities显示文摘Background:The Compendium of Physical Activities was published in 1993 to improve the comparability of energy expenditure values assigned to self-reported physical activity(PA)across studies.The original version was updated in 2000,and again in 2011,and has been widely used to support PA research,practice,and public health guidelines.Methods:This 2024 update was tailored for adults 19-59 years of age by removing data from those≥60 years.Using a systematic review and supplementary searches,we identified new activities and their associated measured metabolic equivalent(MET)values(using indirect calorimetry)published since 2011.We replaced estimated METs with measured values when possible.Results:We screened 32,173 abstracts and 1507 full-text papers and extracted 2356 PA energy expenditure values from 701 papers.We added303 new PAs and adjusted 176 existing MET values and descriptions to reflect the addition of new data and removal of METs for older adults.We added a Major Heading(Video Games).The 2024 Adult Compendium includes 1114 PAs(912 with measured and 202 with estimated values)across 22 Major Headings.Conclusion:This comprehensive update and refinement led to the creation of The 2024 Adult Compendium,which has utility across research,public health,education,and healthcare domains,as well as in the development of consumer health technologies.The new website with the complete lists of PAs and supporting resources is available at http://gffzz09a845152db44f16sk5u6pvuc05fc6kcf.ffgz.tsg.suse.edu.cn. | Stephen D.Herrmann Erik A.Willis Barbara E.Ainsworth Tiago V.Barreira Mary Hastert Chelsea L.Kracht John M.Schuna Jr. Zhenghui Cai Minghui Quan Catrine Tudor-Locke Melicia C.Whitt-Glover David R. Jacobs Jr. | 2024 | Journal of Sport and Health Science2024，13，1： | 4 |
| 4 | Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart: A Statement for Healthcare Professionals From the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association显示文摘 | Manuel D. Cerqueira Neil J. Weissman Vasken Dilsizian Alice K. Jacobs Sanjiv Kaul Warren K. Laskey Dudley J. Pennell John A. Rumberger Thomas Ryan Mario S. Verani | 2002 | Circulation: Journal of the American Heart Association2002，，： | 2 |
| 5 | A Pooled Analysis of Advanced Colorectal Neoplasia Diagnoses After Colonoscopic Polypectomy显示文摘 | María Elena Martínez John A. Baron David A. Lieberman Arthur Schatzkin Elaine Lanza Sidney J. Winawer Ann G. Zauber Ruiyun Jiang Dennis J. Ahnen John H. Bond Timothy R. Church Douglas J. Robertson Stephanie A. Smith–Warner Elizabeth T. Jacobs David S. Alb | 2009 | Gastroenterology2009，，3： | 2 |
| 6 | Associations between nonalcoholic fatty liver disease and subclinical atherosclerosis in middle-aged adults: The Coronary Artery Risk Development in Young Adults Study显示文摘 | Lisa B. VanWagner Hongyan Ning Cora E. Lewis Christina M. Shay John Wilkins J. Jeffrey Carr James G. Terry Donald M. Lloyd-Jones David R. Jacobs Mercedes R. Carnethon | 2014 | Atherosclerosis2014，，2： | 2 |
| 7 | A Systematic Review of the Risk of Perforation During Esophageal Dilation for Patients with Eosinophilic Esophagitis显示文摘 | John William Jacobs Stuart Jon Spechler | 2010 | Digestive Diseases and Sciences2010，，6： | 2 |
| 8 | Recent developments in chemical modification and characterization of natural fiber-reinforced composites 显示文摘 | Maya Jacob John Rajesh D Anandjiwala | 2008 | Polymer Composites2008，29，2： | 1 |
| 9 | Catalysts for the oxidation of soot from diesel exhaust gases II. Contact between soot and catalyst under practical conditions显示文摘 | John P.A. Neeft Olaf P. van Pruissen Michiel Makkee Jacob A. Moulijn | 1997 | Applied Catalysis B, Environmental1997，，1： | 1 |
| 10 | Processing of biodegradable blends of wheat gluten and modified polycaprolactone显示文摘 | Jacob John Jian Tang Mrinal Bhattacharya | 1998 | Polymer1998，39，13： | 1 |
| 11 | Methylation of microRNA-9 is a specific and sensitive biomarker for oral and oropharyngeal squamous cell carcinomas显示文摘 | Jacob Minor Xiaotian Wang Fang Zhang John Song Antonio Jimeno Xiao-Jing Wang Xian Lu Neil Gross Molly Kulesz-Martin Daren Wang Shi-Long Lu | 2011 | Oral Oncology2011，，1： | 1 |
| 12 | Kinetics of the oxidation of diesel soot显示文摘 | John P.A. Neeft T.Xander Nijhuis Erik Smakman Michiel Makkee Jacob A. Moulijn | 1997 | Fuel1997，，12： | 1 |
| 13 | Pegasus: A framework for mapping complex scientific workflows onto distributed systems显示文摘 | Ewa Deelman Gurmeet Singh Mei-Hui Su James Blythe Yolanda Gil Carl Kesselman Gaurang Mehta Karan Vahi G. Bruce Berriman John Good Anastasia Laity Joseph C. Jacob Daniel S. Katz | 2005 | Scientific Programming2005，，3： | 1 |
| 14 | Hemodynamics and vasopressor support in therapeutic hypothermia after cardiac arrest: Prognostic implications显示文摘 | John Bro-Jeppesen Jesper Kjaergaard Helle S?holm Michael Wanscher Freddy K. Lippert Jacob E. M?ller Lars K?ber Christian Hassager | 2013 | Resuscitation2013，，： | 1 |
| 15 | 2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines显示文摘 | Spencer B. King Sidney C. Smith John W. Hirshfeld Alice K. Jacobs Douglass A. Morrison David O. Williams Sidney C. Smith Ted E. Feldman John W. Hirshfeld Alice K. Jacobs Morton J. Kern Spencer B. King Douglass A. Morrison William W. O'Neill Hartzell V. Sc | 2008 | Circulation2008，，2： | 1 |
| 16 | Individual differences in reappraisal ability: Links to reappraisal frequency, well-being, and cognitive control 显示文摘 | McRae K Jacobs S E Ray R D John O P Gross J J | 2012 | Journal of Research in Personality2012，462，： | 1 |
| 17 | Esterase activities of human carbonic anhydrases B and C显示文摘 | Jacob A V Svchinta M John T E | 1967 | Journal of Biological Chemistry1967，242，18： | 1 |
| 18 | Does hyperparathy- roidism cause pancreatitis? A South Indian experience and a review of published work 显示文摘 | Jacob JJ John M Thomas N | 2006 | ANZ J Surg2006，76，8： | 1 |
| 19 | Processing of Biodegradable Blends of Wheat Gluten and Modified Polycaprolactone显示文摘 | Jacob John Jian Tang Mrinal Bhattacharya | 1998 | Polymer1998，39，13： | 1 |
| 20 | Inhibition of prostaglandin synthesis during polystyrene mi- crosphere-induced pulmonary embolism in the rat显示文摘 | Alan E Jones John A Watts Jacob P Debelak | 2003 | Am J Physiol Lung Cell Mol Physiol2003，284，6： | 1 |
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