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您的检索式：作者名="John PLemmon"
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| 1 | 锂金属电池研究中对称电池的短路现象显示文摘锂金属是具有高能量密度的负极材料,是下一代高能量密度电池研究的重点。在锂金属负极的改性研究中,锂对称电池是最常用的测试对象,但判断其短路的依据尚未统一,因此存在部分对短路数据的解析错误。本文利用原位电池对锂沉积过程中由于枝晶生长导致的短路现象进行了描述,对锂金属对称电池在充放电过程中的短路现象进行了分类和讨论。通过区分硬短路、软短路及电池活化过程,提出了判断锂对称电池中枝晶生长及电池短路的依据,为判定锂金属负极改性方法的有效性提供参考。 | 康丹苗 Noam Hart 肖沐野 John PLemmon | 2021 | 物理化学学报2021，37，2： | 2 |
| 2 | Homogenous charge distribution by free-standing porous structure for dendrite-free Li metal anode显示文摘Lithium metal has a high theoretical capacity of 3860 mAh g^-1 and a low electrochemical potential(-3.04 V vs.H2/H^+).Hence,using a lithium anode significantly improves the energy density of a secondary battery.However,the lithium dendrites generated on the lithium anode during the platingdissolution process significantly reduce its cycling life and safety.Here,we provide a simple method for lithium anode protection,by applying a free-standing porous carbon film with a high specific surface area to reduce the local current density and obtain a homogenous ion distribution.The protected lithium anode has a long cycle life over 1000 h when cycled at 3 mA cm^-2 with a lithium capacity of 2.5 mAh cm^-2.Moreover,the deposited lithium has a smoother surface than Li anode without carbon protection.This study will promote the wide application of Li-metal-based batteries with high safety levels. | Danmiao Kang Kun Tang Joonho Koh Wenbin Liang John PLemmon | 2020 | Journal of Energy Chemistry2020，29，5： | 1 |
| 3 | AAV8 transduction capacity is reduced by prior exposure to endosome-like pH conditions显示文摘Adeno-associated virus(AAV)is an essential instrument in the neuroscientist’s toolkit,which allows delivery of DNA to provide labeling with fluorescent proteins or genetic instructions to regulate gene expression.In the field of neural regeneration,the transduction of neurons enables the observation and regulation of axon growth and regeneration,and in the future will likely be a mechanism for delivering molecular therapies to promote sprouting and regeneration after central nervous system injury.Traditional formulations of AAV preparations permit efficient viral transduction under physiologic conditions,but an improved understanding of the mechanistic limitations of AAV transduction may facilitate production of more resilient AAV strains for investigative and therapeutic purposes.We studied AAV transduction in the context of prior exposure of AAV serotype 8(AAV8)to environmental pH within the range encountered during endosomal endocytosis(pH 7.4 to pH 4.4),during which low pH-triggered structural and autoproteolytic changes to the viral capsid are believed to be necessary for endosome escape and virus uncoating.Due to the fundamental nature of these processes,we hypothesized that premature exposure of AAV8 particles to acidic pH would decrease viral transduction of HT1080 cells in vitro,as measured by fluorescent reporter gene expression using high-content imaging analysis.We found that increasingly acidic incubation conditions were associated with concomitant reductions in transduction efficiency,and that quantitative levels of reporter gene expression in transduced cells were similarly decreased.The biggest decrease in transduction occurred between pH 7.4 and pH 6.4,suggesting the possible co-occurrence of a pH-associated event and viral inactivation within that range.Taken together,these findings indicate that exposure of AAV8 to acidic pH for as little as 1 hour is deleterious to transduction ability.Future studies are necessary to understand the pH-associated causative mechanisms involved.This study was approved by the University of Miami Institutional Animal Care and Use Committee,USA(Protocol#18-108-LF)on July 12,2018. | Jeffrey ALowell Kar Men Mah John LBixby Vance PLemmon | 2021 | Neural Regeneration Research2021，16，5： | 0 |
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