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1篇 您的检索式:作者名="Jonathan C.Zhao"
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1Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression显示文摘Dear Editor,F0XA1,a forkhead(FKHD)family transcription factor,is highly expressed in the epithelium of endoderm-derived organs, including the prostate gland.1 Transgenic mouse studies have shown that F0XA1 expression is required for prostate epithelial cell differentiation and ductal morphogenesis during development and for the maintenance of this differentiated epithelial phenotype in the adult. Mechanistically, F0XA1 binds FKHD motifs in the DNA to open chromatin and in crease local accessibility.Bohan Xu Bing Song Xiaodong Lu Jung Kim Ming Hu Jonathan C.Zhao Jindan Yu 2019Cell Research2019,29,9:4
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