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| 1 | Total pancreatectomy and islet autotransplantation: A decade nationwide analysis显示文摘AIM: To investigate outcomes and predictors of inhospital morbidity and mortality after total pancreatectomy(TP) and islet autotransplantation. METHODS: The nationwide inpatient sample(NIS) database was used to identify patients who underwent TP and islet autotransplantation(IAT) between 2002-2012 in the United States. Variables of interest were inherent variables of NIS database which included demographic data(age, sex, and race), comorbidities(such as diabetes mellitus, hypertension, and deficiency anemia), and admission type(elective vs nonelective). The primary endpoints were mortality and postoperative complications according to the ICD-9 diagnosis codes which were reported as the second to 25 th diagnosis of patients in the database. Risk adjusted analysis was performed to investigate morbidity predictors. Multivariate regression analysis was used to identify predictors of in-hospital morbidity.RESULTS: We evaluated a total of 923 patients who underwent IAT after pancreatectomy during 2002-2012. Among them, there were 754 patients who had TP + IAT. The most common indication ofsurgery was chronic pancreatitis(86%) followed by acute pancreatitis(12%). The number of patients undergoing TP + IAT annually significantly increased during the 11 years of study from 53 cases in 2002 to 155 cases in 2012. Overall mortality and morbidity of patients were 0% and 57.8 %, respectively. Postsurgical hypoinsulinemia was reported in 42.3% of patients, indicating that 57.7% of patients were insulin independent during hospitalization. Predictors of inhospital morbidity were obesity [adjusted odds ratio(AOR): 3.02, P = 0.01], fluid and electrolyte disorders(AOR: 2.71, P < 0.01), alcohol abuse(AOR: 2.63, P < 0.01), and weight loss(AOR: 2.43, P < 0.01). CONCLUSION: TP + IAT is a safe procedure with no mortality, acceptable morbidity, and achieved high rate of early insulin independence. Obesity is the most significant predictor of in-hospital morbidity. | Reza Fazlalizadeh Zhobin Moghadamyeghaneh Aram N Demirjian David K Imagawa Clarence E Foster Jonathan R Lakey Michael J Stamos Hirohito Ichii | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 2 | Oral eplerenone for the management of chronic central serous chorioretinopathy显示文摘AIM: To examine eplerenone(Inspra, Pfizer), a mineralocorticoid receptor antagonist, as a treatment option for chronic central serous chorioretinopathy(CSCR).METHODS: A retrospective consecutive case series was conducted for patients receiving oral eplerenone for chronic CSCR. At baseline and each follow-up visit,spectral domain optical coherence tomography(SD-OCT)imaging was performed, including manual measurements of the height and diameter size of subretinal fluid. The primary outcome measure was the reduction in subretinal fluid following initiation of therapy.RESULTS: A total of 17 eyes of 13 patients treated with25 and 50 mg of oral eplerenone per day were identified.Subretinal fluid(SRF) decreased over time following eplerenone therapy(P = 0.007 and P =0.002, diameter and height respectively). Maximum SRF height decreased from a mean of 131.5 μm at baseline to 15.3 μm at day181+. SRF diameter decreased from an average of 2174.4μm at baseline to 46.9 μm at day 181 +. Log MAR visual acuity improved from 0.42(Snellen equivalent: 20/53) at baseline to 0.29(Snellen equivalent: 20/39) at day 181 +(P = 0.024). Central subfield thickness(CST) decreased from 339.5 μm at baseline to 270.3 μm at day 181+(P = 0.029).CONCLUSION: Eplerenone therapy resulted in significant anatomic and visual improvements in eyes with chronic CSCR. | Rishi P Singh Jonathan E Sears Rumneek Bedi Andrew P Schachat Justis P Ehlers Peter K Kaiser | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 6 |
| 3 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 4 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 5 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 6 | Regulatory role of SGTI in early R Gene-Mediated plant defenses显示文摘 | Mark J Paul M Katherine K Bart J Jonathan D G Jane E | 2002 | Science2002，295，15： | 1 |
| 7 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 8 | Relationship between epidemiological risk factors and hormone receptor expression in ovarian cancer: results from the nurses'health study显示文摘 | Jonathan L Joanne K Susan E | 2009 | Cancer Epidemiol Biomarkers Prey2009，18，5： | 1 |
| 9 | Evaluation of Mannich Bases of 2-arylidene-1,3- diketones Versus Murine P388 Leukemia 显示文摘 | JONATHAN R D SRINIVAS K R GLEN E B | 1988 | Eur J Med Chem1988，23，2： | 1 |
| 10 | Ross young labor-associated regulation of prostaglandin E and F synthesis and action in the ovine amnion and cervix显示文摘 | Hannah K Jonathan J Gregory E | 2006 | J Soc Gynecol Investig2006，21，： | 1 |
| 11 | Relationship between epi- demiological risk factors and hormone receptor expression in ovarian cancer:results from the nurses'health study 显示文摘 | Jonathan L Joanne K Susan E | 2009 | Cancer Epidemiol Biomarkers Prev2009，18，5： | 1 |
| 12 | Re-flooding a historically drained wetland leads to rapid sediment phosphorus release显示文摘 | LAUREN E K JONATHAN O STEPHEN K H | 2014 | Ecosystems2014，17，4： | 1 |
| 13 | Synchronous primary neoplasms of the female reproductive tract显示文摘 | ROBIN F E ROBERTA K N JONATHAN T B | 1989 | Gynecologic Oncology1989，33，3： | 1 |
| 14 | Evaluation of Mannich bases of 2-arylidene-1,3-diketones versus mu- rine P388 leukemia 显示文摘 | Jonathan R D Srinivas K R Glen E B | 1988 | Eur J Med Chem1988，23，： | 1 |
| 15 | Two-step Triangular- pattern Phase-shifting Method for Three-dimensional Object-shape Measurement显示文摘 | Jia Peirong Jonathan K Chad E | 2007 | Optical Engineering2007，46，8： | 1 |
| 16 | Repeated phase-offset measurement for error compensation in two-step triangular phase-shifting profilometry 显示文摘 | PEIRONG J JONATHAN K CHAN E | 2006 | Optomechatronic Sensors Instrumentation and Computer-Vision Systems2006，6375，63： | 1 |
| 17 | Holmes treating opportunistic infections among HIV-infected adults and adolescent 显示文摘 | CONSTANCE A B JONATHAN E K HENTY M | 2004 | MMWR Recornm Rep2004，53，15： | 1 |
| 18 | Two-step triangular-pattern phase-shifting method for three-dimension object-shape measurement 显示文摘 | PEIRONG J JONATHAN K CHAN E | 2007 | Optical Engineering2007，46，8： | 1 |
| 19 | Intensity-ratio error compensatiaon for triangular-pattern phase-shifting profilmetry显示文摘 | PEIRONG J JONATHAN K CHAN E | 2007 | Optical Society of America2007，24，10： | 1 |
| 20 | Correlation of postpercutaneous coronary intervention creatine kinase-MB and troponin I elevation in predicting mid-term mortality显示文摘 | Annapoorna S Kini Paul Lee Jonathan D Marmur Ajay Agarwal Mary E Duffy Michael C Kim Samin K Sharma | 2004 | The American Journal of Cardiology2004，，1： | 1 |
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