| 1 | Mixed neuroendocrine-non-neuroendocrine neoplasms of the digestive system:A mini-review显示文摘Mixed neuroendocrine-non-neuroendocrine neoplasms(MiNENs)are rare mixed tumors containing both neuroendocrine(NE)and non-NE components.Each component must occupy at least 30%of the tumor volume by definition.Recent molecular evidence suggests MiNENs are clonal neoplasms and potentially harbor targetable mutations similar to conventional carcinomas.There have been multiple changes in the nomenclature and classification of MiNENs which has created some confusion among pathologists on how to integrate the contributions of each component in a MiNEN,an issue which in turn has resulted in confusion in communication with front-line treating oncologists.This mini review summarizes our current understanding of MiNENs and outline diagnosis,prognosis,and management of these neoplasms.The authors emphasize the importance of treating the most aggressive component of the tumor regardless of its percentage volume. | Deepak Toor Jonathan M Loree Zu-Hua Gao Gang Wang Chen Zhou | 2022 | World Journal of Gastroenterology2022，28，19： | 2 |
| 2 | Real-world treatment attrition rates in advanced esophagogastric cancer显示文摘BACKGROUND Over the last decade,multiple agents have demonstrated efficacy for advanced esophagogastric cancer(EGC).Despite the availability of later lines of therapy,there remains limited real-world data about the treatment attrition rates between lines of therapy.AIM To characterize the use and attrition rates between lines of therapy for patients with advanced EGC.METHODS We identified patients who received at least one cycle of chemotherapy for advanced EGC between July 1,2017 and July 31,2018 across six regional centers in British Columbia(BC),Canada.Clinicopathologic,treatment,and outcomes data were extracted.RESULTS Of 245 patients who received at least one line of therapy,median age was 66 years(IQR 58.2-72.3)and 186(76%)were male,Eastern Cooperative Oncology Group(ECOG)performance status 0/1(80%),gastric vs GEJ(36%vs 64%).Histologies included adenocarcinoma(78%),squamous cell carcinoma(8%),and signet ring(14%),with 31%HER2 positive.72%presented with de novo disease,and 25%had received previous chemoradiation.There was a high level of treatment attrition,with patients receiving only one line of therapy n=122,50%),two lines n=83,34%),three lines n=34,14%),and four lines n=6,2%).Kaplan-Meier analysis demonstrated improved survival with increasing lines of therapy(median overall survival 7.7 vs 16.6 vs 22.8 vs 40.4 mo,P<0.05).On multivariable Cox regression,improved survival was associated with better baseline ECOG and increased lines of therapy(P<0.05).CONCLUSION The steep attrition rates between therapies highlight the unmet need for more efficacious early-line treatment options for patients with advanced EGC. | Erica S Tsang Howard J Lim Daniel J Renouf Janine M Davies Jonathan M Loree Sharlene Gill | 2020 | World Journal of Gastroenterology2020，26，39： | 0 |
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