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| 1 | Colorectal cancer in patients under 50 years of age:A retrospective analysis of two institutions' experience显示文摘AIM:To investigate the epidemiological characteristics of colorectal cancer(CRC)in patients under 50 years of age across two institutions.METHODS:Records of patients under age 50 years of age who had CRC surgery over a 16 year period were assessed at two institutions.The following documents where reviewed:admission notes,operative notes,and discharge summaries.The main study variables included:age,presenting symptoms,family history,tumor location,operation,stage/differentiation of disease,and post operative complications.Stage of disease was classified according to the American Joint Committee on Cancer TNM staging system:tumor depth;node status;and metastases.RESULTS:CRC was found in 180 patients under age50 years(87 females,93 males;mean age 41.4±6.2years).Young patients accounted for 11.2%of cases during a 6 year period for which the full data set wasavailable.Eight percent had a 1stdegree and 12%a 2nd degree family CRC history.Almost all patients(94%)were symptomatic at diagnosis;common symptoms included:bleeding(59%),obstruction(9%),and abdominal/rectal pain(35%).Evaluation was often delayed and bleeding frequently attributed to hemorrhoids.Advanced stage CRC(Stage 3 or 4)was noted in 53%of patients.Most tumors were distal to the splenic flexure(77%)and 39%involved the rectum.Most patients(95%)had segmental resections;6 patients had subtotal/total colectomy.Poorly differentiated tumors were noted in 12%and mucinous lesions in 19%of patients of which most had Stage 3 or 4 disease.Twenty-two patients(13%)developed recurrence and/or progression of disease to date.Three patients(ages 42,42and 49 years)went on to develop metachronous primary colon cancers within 3 to 4 years of their initial resection.CONCLUSION:CRC was common in young patients with no family history.Young patients with symptoms merit a timely evaluation to avoid presentation with late stage CRC. | Elizabeth A Myers Daniel L Feingold Kenneth A Forde Tracey Arnell Joon Ho Jang Richard L Whelan | 2013 | World Journal of Gastroenterology2013，19，34： | 9 |
| 2 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 3 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 4 | Estimation of Survival Proba- Bility for a Ship in Beam Seas using the Safe Basin显示文摘 | Zhan J L Seung K L Joon Y K | 2010 | Ocean Engng2010，，37： | 1 |
| 5 | Quantitation of carnosine in humans plasma after dietary consumption of beef显示文摘 | Park Young Joon Volpe Stella L Decker Eric A | 2005 | Journal of agricultural and food chemistry2005，53，12： | 1 |
| 6 | Primary colorectal lymphoma: spectrum of imaging findings with pathologic correlation显示文摘 | Hyun J L Joon K H | 2002 | European Radiology2002，12，： | 1 |
| 7 | Adiponectin levels and Risk of type 2 disbetes 显示文摘 | Shanshan Li Hyun Joon Shin Eric L | 2009 | The journal of the American Medical Association2009，302，2： | 1 |
| 8 | Characterization of poly(vinyl pivalate) polymerized in tertiary butyl alcohol and resulting syndiotactic poly(vinyl alcohol) microfibrils saponified显示文摘 | WON S L JOON H K HAND G | 2001 | Polymer2001，42，14： | 1 |
| 9 | Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection显示文摘AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC resection.METHODS: A plasma bank was screened for minimally invasive colorectal cancer resection(MICR) for CRC and benign disease(BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples(postoperative day 7-27) were available. Monocyte chemotactic protein-1(MCP-1) levels(pg/mL) were determined via enzyme linked immuno-absorbent assay. RESULTS: One hundred and two CRC and 86 BEN patients were studied. The CRC patient's median preoperative MCP-1 level(283.1, CI: 256.0, 294.3) was higher than the BEN group level(227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1(446.3, CI: 418.0, 520.1), postoperative day 3(342.7, CI: 320.4, 377.4), postoperative day 7-13(326.5, CI: 299.4, 354.1), postoperative day 14-20(361.6, CI: 287.8, 407.9), and postoperative day 21-27(318.1, CI: 287.2, 371.6; P < 0.001 for all). CONCLUSION: Preoperative MCP-1 levels were higher in CRC patients(vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis. | HMC Shantha Kumara Elizabeth A Myers Sonali AC Herath Joon Ho Jang Linda Njoh Xiaohong Yan Daniel Kirchoff Vesna Cekic Martin Luchtefeld Richard L Whelan | 2014 | World Journal of Gastrointestinal Oncology2014，6，10： | 1 |
| 10 | Development of a newbiomonitoring method to detect the abnormal activity ofDaphnia magna using automated Grid Counter device显示文摘 | Junho J Joon H K Byung C L | 2008 | Science of the total environment2008，389，： | 1 |
| 11 | Transfer alignment considering measurement time delay and ship body flexure显示文摘 | JOON L YOU-CHOL L | 2009 | Journal of Mechanical Science and Technology2009，23，1： | 1 |
| 12 | Defect detection method for 1TT-LCD panel based on saliency map model显示文摘 | Kyu B L Min S K Joon J L | 2004 | IEEEInternational Symposium2004，，4： | 1 |
| 13 | Pressure and flow distribution in internal gas manifolds of a fuel-cell stack显示文摘 | Joon Ho Koh Hai Kyung Seo Choong G L | 2003 | Journal of Power Sources2003，，115： | 1 |
| 14 | An Improvement of AUSM Schemes by Introducing the Pressure- Based Weight Func- tions 显示文摘 | Kim K H Joon H L Rho O H | 1998 | Computer&Fluids1998，27，3： | 1 |
| 15 | Experimental study on the flow characteristics of streamwise inclined jets in crossflow on flat plate显示文摘 | Sang W L Joon S L Sung T R | 1994 | ASME Journal of Turbomachinery1994，116，1： | 1 |
| 16 | The Anti-influenza Virus Effect of Phellinus igniarius Extract显示文摘 | Sangmoo L Jin Il K Jun H Ilseob L Sehee P Min W H Joon Y B Mee S P Hyoung J P Man S P | 2013 | Journal of Microbiology2013，51，5： | 1 |
| 17 | Treatment options for wide-necked intracranial aneurysms using a self-expandable hydrophilic coil and a self-expandable stent combination显示文摘 | Brisman Joon K | 2005 | Am J Neuroradiol2005，26，： | 1 |
| 18 | Transfer alignment error compensator design based on robust state estimation显示文摘 | Joon L You-Chol L | 2005 | Transactions of the Japan Society for Aeronautical and Space Sciences2005，48，61： | 1 |
| 19 | Transfer alignment considering measurement time delay and ship body flexure显示文摘 | Joon L You-Chol L | 2009 | Journal of Mechanical Science and Technology2009，23，1： | 1 |
| 20 | Optimal single deletion correcting code of length four over an alphabet of even size显示文摘 | Hyun K K Joon Y L Dong Y O | | 0，，07： | 1 |
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