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1篇 您的检索式:作者名="Joonbeom Bae"
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1Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8^(+) T cells显示文摘Dear Editor,CLDN18.2(CLDN),a member of tight junction protein family,is strictly limited to express on differentiated epithelial cells of the gastric mucosa and abnormal overexpression has been found in many cancers,especially in digestive system malignancies.1 Those features make CLDN a potential therapeutic target.However,monoclonal antibody targeting CLDN induce limited antitumor immune responses in clinical trials and fusion of strong immunomodulators might be needed to enhance its efficacy.High dose IL-2 activates tumor infiltrating lymphocytes(TILs),but the severe toxicity and poor tumor targeting limits its use.Xue Wang Longchao Liu Tao Yue Zhichen Sun Joonbeom Bae Kuo-Fu Tseng Anli Zhang Jian Qiao Yang-Xin Fu 2023Signal Transduction and Targeted Therapy2023,8,8:0
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