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| 1 | Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin显示文摘AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients. | Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C Espinós Josep M Viver Antonio Salas Fernando Fernández-Baares | 2013 | World Journal of Gastroenterology2013，19，26： | 13 |
| 2 | Translating auxin responses into ovules, seeds and yield: Insight from Arabidopsis and the cereals显示文摘Grain production in cereal crops depends on the stable formation of male and female gametes in the flower.In most angiosperms, the female gamete is produced from a germline located deep within the ovary, protected by several layers of maternal tissue, including the ovary wall,ovule integuments and nucellus. In the field, germline formation and floret fertility are major determinants of yield potential, contributing to traits such as seed number,weight and size. As such, stimuli affecting the timing and duration of reproductive phases, as well as the viability,size and number of cells within reproductive organs can significantly impact yield. One key stimulant is the phytohormone auxin, which influences growth and morphogenesis of female tissues during gynoecium development, gametophyte formation, and endosperm cellularization. In this review we consider the role of the auxin signaling pathway during ovule and seed development, first in the context of Arabidopsis and then in the cereals. We summarize the gene families involved and highlight distinct expression patterns that suggest a range of roles in reproductive cell specification and fate. This is discussed in terms of seed production and how targeted modification of different tissues might facilitate improvements. | Neil J.Shirley Matthew K.Aubert Laura G.Wilkinson Dayton C.Bird Jorge Lora Xiujuan Yang Matthew R.Tucker | 2019 | Journal of Integrative Plant Biology2019，61，3： | 3 |
| 3 | Genetic and biologic characteristics of Toxoplasma gondii isolates in free-range chickens from Colombia, South America显示文摘 | J.P. Dubey Jorge E. Gomez-Marin Angela Bedoya Fabiana Lora M.C.B. Vianna D. Hill O.C.H. Kwok S.K. Shen P.L. Marcet T. Lehmann | 2005 | Veterinary Parasitology2005，，1： | 1 |
| 4 | Octogenarian liver grafts:Is their use for transplant currently justified?显示文摘AIM To analyse the impact of octogenarian donors in liver transplantation.METHODS We present a retrospective single-center study, performed between November 1996 and March 2015, that comprises a sample of 153 liver transplants. Recipients were divided into two groups according to liver donor age: recipients of donors ≤ 65 years(group A; n = 102), and recipients of donors ≥ 80 years(group B; n = 51). A comparative analysis between the groups was performed. Quantitative variables were expressed as mean values and SD, and qualitative variables as percentages. Differences in properties between qualitative variables were assessed by χ2 test. Comparison of quantitative variables was made by t-test. Graft and patient survivals were estimated using the Kaplan-Meier method.RESULTS One, 3 and 5-year overall patient survival was 87.3%, 84% and 75.2%, respectively, in recipients of younger grafts vs 88.2%, 84.1% and 66.4%, respectively, in recipients of octogenarian grafts(P = 0.748). One, 3 and 5-year overall graft survival was 84.3%, 83.1% and 74.2%, respectively, in recipients of younger grafts vs 84.3%, 79.4% and 64.2%, respectively, in recipients of octogenarian grafts(P = 0.524). After excluding the patients with hepatitis C virus cirrhosis(16 in group A and 10 in group B), the 1, 3 and 5-year patient(P = 0.657) and graft(P = 0.419) survivals were practically the same in both groups. Multivariate Cox regression analysis demonstrated that overall patient survival was adversely affected by cerebrovascular donor death, hepatocarcinoma, and recipient preoperative bilirubin, and overall graft survival was adversely influenced by cerebrovascular donor death, and recipient preoperative bilirubin.CONCLUSION The standard criteria for utilization of octogenarian liver grafts are: normal gross appearance and consistency, normal or almost normal liver tests, hemodynamic stability with use of < 10 μg/kg per minute of vasopressors before procurement, intensive care unit stay < 3 d, CIT < 9 h, absence of atherosclerosis in the hepatic and gastroduodenal arteries, and no relevant histological alterations in the pre-transplant biopsy, such as fibrosis, hepatitis, cholestasis or macrosteatosis > 30%. | Carlos Jiménez-Romero Felix Cambra Oscar Caso Alejandro Manrique Jorge Calvo Alejandro Marcacuzco Paula Rioja David Lora Iago Justo | 2017 | World Journal of Gastroenterology2017，23，17： | 1 |
| 5 | Self-assembly as a tool to study microscale curvature and strain-dependent magnetic properties显示文摘The extension of 2D ferromagnetic structures into 3D curved geometry enables to tune its magnetic properties such as uniaxial magnetic anisotropy.Tuning the anisotropy with strain and curvature has become a promising ingredient in modern electronics,such as flexible and stretchable magnetoelectronic devices,impedance-based field sensors,and strain gauges,however,has been limited to extended thin films and to only moderate bending.By applying a self-assembly rolling technique using a polymeric platform,we provide a template that allows homogeneous and controlled bending of a functional layer adhered to it,irrespective of its shape and size.This is an intriguing possibility to tailor the sign and magnitude of the surface strain of integrated,micronsized devices.In this article,the impact of strain and curvature on the magnetic ground state and anisotropy is quantified for thinfilm Permalloy micro-scale structures,fabricated on the surface of the tubular architectures,using solely electrical measurements. | Balram Singh Jorge A.Otálora Tong H.Kang Ivan Soldatov Dmitriy D.Karnaushenko Christian Becker Rudolf Schäfer Daniil Karnaushenko Volker Neu Oliver G.Schmidt | 2022 | npj Flexible Electronics2022，6，1： | 0 |
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