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| 1 | Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome显示文摘BackgroundThere 是在质子泵禁止者(PPI ) 和 clopidogrel 之间的可能的不利相互作用上的大争论。另外, PPI 的使用是否少些影响 ticagrelor 遗体的临床的功效,知道。在经皮的冠的干预(一种总线标准) .MethodsWe 回顾地从 “ 分析了数据以后,我们试图与急性冠的症候群(交流)在病人在临床的结果上决定 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响;真实 world” ;,国际,在 2003 和 2014 之间的多中心登记( n = 15,401 )并且在1年的合成主要端点上估计了 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响(所有原因死亡收到 PPI 的病人更老,更经常女性,并且是更可能的有 comorbidities。没有协会为收到 clopidogrel 的病人在 PPI 使用和主要端点之间被观察(调整 HR:1.036;95% CI:0.903-1.189 ) 或 ticagrelor (调整 HR:2.320;95% CI:0.875-6.151 )(P 相互作用 = 0.2004 ) 。同样, PPI 的使用没与所有原因死亡,重新梗塞,或与交流后面的一种总线标准的为与任何一个 clopidogrel 对待的病人或 ticagrelor.ConclusionsIn 病人的严重流血的减少的风险的增加的风险被联系, PPI 的伴随物使用没在收到 clopidogrel 或 ticagrelor 的病人与不利结果的增加的风险被联系。我们的调查结果显示与 clopidogrel 或 ticagrelor 在联合使用 PPI 是合理的,特别在有胃肠的流血的更高的风险的病人。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzfilez-Juanatey Stephen B Wilton Wouter J Kikkert Ivlin Nufiez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiril Sasko Kedev | 2016 | Journal of Geriatric Cardiology2016，13，3： | 12 |
| 2 | Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants显示文摘For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial(DFM) can be the most suitable solutions. Microorganisms that are commonly used in DFM for ruminants may be classified mainly as lactic acid producing bacteria(LAB), lactic acid utilizing bacteria(LUB), or other microorganism's species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, Megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFM has not been established; although a variety of mechanisms have been suggested. Bacterial DFM potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFM may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFM may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFM administration. However, the response to DFM is not constant; depending on dosages, feeding times and frequencies, and strains of DFM. Nonetheless, recent studies have supported the positive effects of DFM on ruminant performance. | Mona M Y Elghandour Abdelfattah Z M Salem Jose S Martínez Castaeda Luis M Camacho Ahmed E Kholif Juan C Vázquez Chagoyán | 2015 | Journal of Integrative Agriculture2015，14，3： | 7 |
| 3 | P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析显示文摘目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂(PPI)治疗对经皮冠状动脉介入(PCI)术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究,纳入2003至2014年因急性冠脉综合征人院行PCI术的患者,分为PPI组及非PPI组并随访1年,主要临床终点为全因死亡/再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类,将入组患者分为氯吡格雷组及替格瑞洛组,并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者,PPI组占54.8%,具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡/再发心肌梗死复合事件的发生差异无统计学意义(HR1.00,95%CI 0.86—1.18)。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组,不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异,联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险,尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。 | 冯斯婷 严妍 范婧尧 王晓 郑文 聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo Jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiri Sasko Kedev | 2016 | 中华医学杂志2016，96，33： | 6 |
| 4 | AMP-activated kinase in human spermatozoa: identification, intracellular localization, and key function in the reRulation of sperm motility显示文摘 | Violeta Calle-Guisado Ana Hurtado de Llera David Martin-Hidalgo Jose Mijares Maria C Gil Ignacio S Alvarez Maria J Bragado Luis J Garcia-Marin | 2017 | Asian Journal of Andrology2017，19，6： | 5 |
| 5 | Chitosan and Chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as noval carriers for proteins and vaccines显示文摘 | PILAR C CARMEN R L JOSE LUIS V J | 1997 | Pharm Res1997，14，10： | 1 |
| 6 | A distribution company energy acquisition market model with integration of distributed generation and load curtailment option显示文摘 | Palma-Behnke R Jose L C A Luis S V | 2005 | IEEE Trans on Power Systems2005，20，4： | 1 |
| 7 | High- strength steel development for pipelines: a Brazilian perspective 显示文摘 | Ivanide S B de Luis F G S Jose C G T | 2005 | Metallurgical and Materials Transactions A2005，36，44： | 1 |
| 8 | Study of the presence of pesticides in surface waters in the Ebro river basin (Spain)显示文摘 | Ana C Pena O Luis R Jose L O | 2006 | Chemosphere2006，4，： | 1 |
| 9 | Kinetics of the initial stage of sintering from shrinkage data: Simultaneous determination of activation energy and kinetic model from a single nonisotherrnal experiment显示文摘 | MAQUEDA P LUIS P M JOSE M C CONCEPCION R | 2002 | J Am Ceram Soc2002，85，： | 1 |
| 10 | Recurrent primary cerebral hemorrhage:frequency,mechanisms,and prognosis显示文摘 | Alejandra G Duurte Carlos C Jose Luis Ru | 1998 | Stroke1998，29，3： | 1 |
| 11 | Global profiling in vestibular schwannomas shows critical deregulation of microRNAs and upregulation in those included in chromosomal region 14q32 显示文摘 | MIGUEL T M LUIS L JOSE M C | 2013 | PLOS One2013，8，65： | 1 |
| 12 | Novel emissive bio-inspired non-proteinogenic coumarin-ala- nine amino acid:Fluorescent probe for polyfunctional systems 显示文摘 | Elisabete O Jose Luis C Joao C L | 2012 | Amino Acids2012，43，： | 1 |
| 13 | The role of nutrient availability inregulating root architecture显示文摘 | Jose L B Alfredo C R Luis H E | 2003 | Current Opinion in Plant Biology2003，6，： | 1 |
| 14 | Kernel antenna array processing显示文摘 | Manel M R Jose Luis R á Gustavo C V | 2007 | IEEE Transactions on Antennas and Propagation2007，55，3： | 1 |
| 15 | Ant colony optimization for learning Bayesian networks显示文摘 | LUIS M C JUAN M F JOSE A G | 2002 | International Journal of Approximate Reasoning2002，31，： | 1 |
| 16 | A distribution company energy acquisition market model with integration of distributed generation and load curtailment options显示文摘 | Palma-Behnke R Jose L C A Luis S V | 2005 | IEEE Trans on Power Systems2005，20，4： | 1 |
| 17 | Management of hepatic hemangiomas: A 14-year experience显示文摘 | Paulo Herman M.D. Ph.D. Marcelo L. V. Costa M.D. Marcel Autran Cesar Machado M.D. Ph.D. Vincenzo Pugliese M.D. Ph.D. Luis Augusto Carneiro D'Albuquerque M.D. Ph.D. Marcel Cerqueira César Machado M.D. Ph.D. Joaquim Jose Gama-Rodrigues M.D. Ph.D. Will | 2005 | Journal of Gastrointestinal Surgery2005，，6： | 1 |
| 18 | Synthesis of cepharanone显示文摘 | Luis C Enrique G Jose S M | 1982 | Heterocycles1982，19，2： | 1 |
| 19 | Proteomics as an approach to the understanding of the molecular physiology of fruit development and ripening显示文摘 | JOSE M P FRANCISCO J C LUIS A R | 2011 | Journal of Proteomics2011，74，8： | 1 |
| 20 | Ant colony optimization for learning Bayesian networks 显示文摘 | LUIS M C JUAN M F JOSE A G | 2002 | International Journal of Approximate Reasoning2002，31，3： | 1 |
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