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1篇 您的检索式:作者名="Jose M.Fuentes"
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1The dual role of necrostatin-1 in Parkinson’s disease models显示文摘Neuronal cell death is the main hallmark of Parkinson’s disease(PD).It is an irreversible process promoted by neurotoxins and/or genetic mutations.Different types of cell death have been associated with PD.The mechanisms by which neurons decide to specific type of cell death remain elusive.However,it is well known that cell death can be either programmed or not.Apoptosis is a programmed cell death that involves the release of cytochrome c from damaged mitochondria to cytosol and the activation of caspases leading to nuclear condensation.Necrosis is a caspase-independent cell death characterized by a gain in cell volume,rupture of plasma membrane and leak of cell contents,inflammation,and affects neighbouring cells.It was classified as a nonprogrammed cell death,but there are types of necrotic death triggered by a protein activation cascade,including necroptosis.Eva Alegre-Cortes Guadalupe Martinez-Chacon Jose M.Fuentes Sokhna M.S.Yakhine-Diop 2021Neural Regeneration Research2021,16,10:0
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