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| 1 | Patterns of local recurrence in rectal cancer after a multidisciplinary approach显示文摘Improvements in surgery and the application of combined approaches to fight rectal cancer have succeeded in reducing the local recurrence (LR) rate and when there is LR it tends to appear later and less often in isolation. Moreover, a subtle change in the distribution of LRs with respect to the pelvis has been observed. In general terms, prior to total mesorectal excision the most common LRs were central types (perianastomotic and anterior) while lateral and posterior forms (presa-cral) have become more common since the growth in the use of combined treatments. No differences have been reported in the current pattern of LRs as a function of the type of approach used, that is, neo-adjuvant therapies (short-term or long-course radiotherapy, orchemoradiotherapy versus extended lymphadenectomy, though there is a trend towards posterior or presacral LR in patients in the Western world and lateral LR in Asia. Nevertheless, both may arise from the same mechanism. Moreover, as well as the mode of treatment, the type of LR is related to the height of the initial tumor. Nowadays most LRs are related to the advanced nature of the disease. Involvement of the circumferential radial margin and spillage of residual tumor cells from lymphatic leakage in the pelvic side wall are two plausible mechanisms for the genesis of LR. The patterns of pelvic recurrence itself (pelvic subsites) also have important implications for prognosis and are related to the potential success of salvage curative approach. The re-operability for cure and prognosis are generally better for anastomotic and anterior types than for presacral and lateral recurrences. Overall survival after LR diagnosis is lower with radio or chemoradiotherapy plus optimal surgery approaches, compared to optimal surgery alone. | Jose M Enríquez-Navascués Nerea Borda Aintzane Liz-erazu Carlos Placer Jose L Elosegui Juan P Ciria Adelaida Lacasta Luis Bujanda | 2011 | World Journal of Gastroenterology2011，17，13： | 14 |
| 2 | Hepatitis B and inflammatory bowel disease: Role of antiviral prophylaxis显示文摘Hepatitis B virus (HBV) is a very common infection worldwide. Its reactivation in patients receiving immunosuppression has been widely described as being associated with significant morbidity and mortality unless anti-viral prophylaxis is administered. Treatment in inflammatory bowel disease (IBD) patients has changed in recent years and immunosuppression and biological therapies are now used more frequently than before. Although current studies have reported an incidence of hepatitis B in inflammatory bowel disease patients similar to that in the general population, associated liver damage remains an important concern in this setting. Liver dysfunction may manifest in several ways, from a subtle change in serum aminotransferase levels to fulminant liver failure and death. Patients undergoing double immunosuppression are at a higher risk, and reactivation usually occurs after more than one year of treatment. As preventive measures, all IBD patients should be screened for HBV markers at diagnosis and those who are positive for the hepatitis B surface antigen should receive antiviral prophylaxis before undergoing immunosuppression in order to avoid HBV reactivation. Tenofovir/entecavir are preferred to lamivudine as nucleos(t)ide analogues due to their better resistance profile. In patients with occult or resolved HBV, viral reactivation does not appear to be a relevant issue and regular DNA determination is recommended during immunosuppression therapy. Consensus guidelines on this topic have been published in recent years. The prevention and management of HBV infection in IBD patients is addressed in this review in order to address practical | Pilar López-Serrano Jose Lázaro Pérez-Calle Maria Dolores Sánchez-Tembleque | 2013 | World Journal of Gastroenterology2013，19，9： | 12 |
| 3 | Timely reperfusion for ST-segment elevation myocardial infarction:Effect of direct transfer to primary angioplasty on time delays and clinical outcomes显示文摘Primary percutaneous coronary intervention(PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction(STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the benefit of selecting this therapeutic option. Several strategies have been proposed to decrease the temporal delays to deliver PPCI. Among them,prehospital diagnosis and direct transfer to the cath lab,by-passing the emergency department of hospitals,has emerged as anattractive way of diminishing delays. The purpose of this review is to address the effect of direct transfer on time delays and clinical events of patients with STEMI treated by PPCI. | Rodrigo Estévez-Loureiro ángela López-Sainz Armo Pérez de Prado Carlos Cuellas Ramón Calvio Santos Norberto Alonso-Orcajo Jorge Salgado Fernández Jose Manuel Vázquez-Rodríguez Maria López-Benito Felipe Fernández-Vázquez | 2014 | World Journal of Cardiology2014，6，6： | 6 |
| 4 | Effectiveness of an intervention for reducing social stigma towards mental illness in adolescents显示文摘AIM: To evaluate the effectiveness of an intervention for reducing social stigma towards mental illness in adolescents. The effect of gender and knowledge of someone with mental illness was measured. METHODS: Two hundred and eighty secondary school students were evaluated using the Community Attitudes towards Mental Illness(CAMI) questionnaire. The schools were randomized and some received the intervention and others acted as the control group. The programme consisted of providing information via a documentary film and of contact with healthcare staff in order to reduce the social stigma within the school environment. RESULTS: The intervention was effective in reducing the CAMI authoritarianism and social restrictiveness subscales. The intervention showed significant changes in girls in terms of authoritarianism and social restrictiveness, while boys only showed significant changes in authoritarianism. Following the intervention, a significant reduction was found in authoritarianism and social restrictiveness in those who knew someone with mental illness, and only in authoritarianism in those who did not know anyone with mental illness. CONCLUSION: The intervention was effective to reduce social stigma towards people with mental illness, especially in the area of authoritarianism. Some differences were found depending on gender and whether or not the subjects knew someone with mental illness. | Regina Vila-Badia Francisco Martínez-Zambrano Otilia Arenas Emma Casas-Anguera Esther García-Morales Raúl Villellas José Ramón Martín María Belén Pérez-Franco Tamara Valduciel Diana Casellas Mar García-Franco Jose Miguel Joaquim Balsera Gemma Pascual Eugènia Julia Susana Ochoa | 2016 | World Journal of Psychiatry2016，6，2： | 4 |
| 5 | Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: When and how to apply prophylaxis, with a special focus on corticosteroid therapy显示文摘Currently immunosuppressive and biological agentsare used in a more extensive and earlier way in patients with inflammatory bowel disease, rheumatic or dermatologic diseases. Although these drugs have shown a significant clinical benefit, the safety of these treatments is a challenge. Hepatitis B virus(HBV) reactivations have been reported widely, even including liver failure and death, and it represents a deep concern in these patients. Current guidelines recommend to preemptive therapy in patients with immunosuppressants in general, but preventive measures focused in patients with corticosteroids and inflammatory diseases are scarce. Screening for HBV infection should be done at diagnosis. The patients who test positive for hepatitis B surface antigen, but do not meet criteria for antiviral treatment must receive prophylaxis before undergoing immunosuppression, including corticosteroids at higher doses than prednisone 20 mg/d during more than two weeks. Tenofovir and entecavir are preferred than lamivudine because of their better resistance profile in long-term immunosuppressant treatments. There is not a strong evidence, to make a general recommendation on the necessity of prophylaxis therapy in patients with inflammatory diseases that are taking low doses of corticosteroids in short term basis or low systemic bioavailability corticosteroids such as budesonide or beclomethasone dipropionate. In these cases regularly HBV DNA monitoring is recommended, starting early antiviral therapy if DNA levels begin to rise. In patients with occult or resolved hepatitis the risk of reactivation is much lower, and excepting for Rituximab treatment, the prophylaxis is not necessary. | Pilar López-Serrano Elsa de la Fuente Briongos Elisa Carrera Alonso Jose Lázaro Pérez-Calle Conrado Fernández | 2015 | World Journal of Hepatology2015，7，3： | 4 |
| 6 | Vaccines and recommendations for their use in inflammatory bowel disease显示文摘The patient with inflammatory bowel disease will be predisposed to numerous infections due their immune status. It is therefore important to understand the immune and serologic status at diagnosis and to put the patient into an adapted vaccination program. This program would be applied differently according to two patient groups: the immunocompromised and the non-immunocom-promised. In general, the first group would avoid the use of live-virus vaccines, and in all cases, inflammatory bowel disease treatment would take precedence over vaccine risk. It is important to individualize vaccination schedules according to the type of patient, the treatment used and the disease pattern.In addition, patient with inflammatory bowel disease should be considered for the following vaccines: varicella vaccine, human papilloma virus, influenza, pneumococcal polysaccharide vaccine and hepatitis B vaccine. | María Dolores Sánchez-Tembleque Carmen Corella Jose L Pérez-Calle | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 7 | The effect of the operating point on the pressure fluctuations at the blade passage frequency in the volute of a centrifugal pump显示文摘 | Jorge L P Jose G Joaquin F | 2002 | Journal of Fluids Engineering2002，124，3： | 1 |
| 8 | Parallcl ization of the Scatter Search for the p median Problem 显示文摘 | FELIX G L BELEN M B JOSE A M P | 2003 | Parallel Computing2003，29，5： | 1 |
| 9 | Evaluation of antibacterial activity of Zanthoxylum rhetsa seed essential oil显示文摘 | Jose B Reddy L J Shaft P | 2009 | Inter- national Journal of Agriculture Environment & Biotechnology2009，，4： | 1 |
| 10 | Tillage effects on soil properties and crop production in the sub-humid and semiarid Argentinean Pampas 显示文摘 | Daniel E B Jose L P Paul W U | 1998 | Soil & Tillage Res1998，49，： | 1 |
| 11 | Sugarcane micropropa- gation and phenolic excretion显示文摘 | Jose C L Marfa de los AB Osvaldo P | 2001 | Plant Cell2001，65，： | 1 |
| 12 | Invasive species can handle higher leaf temperature under water stress than Mediterranean natives显示文摘 | Oscar G Jose P L Fernando V | 2011 | Envi- ronmental and Experimental Botany2011，71，2： | 1 |
| 13 | Seismic Damage Identification in Buildings Using Neural Networks and Modal Data显示文摘 | Maria P Gonzalez Jose L Zapico | 2008 | Computers & Structures2008，86，35： | 1 |
| 14 | Trace Analysis of Seven Neonicotinoid Insecticides in Bee Pollen by Solid-liquid Extraction and Liquid Chromatography Coupled to Electrospray Ionization Mass Spectrometry显示文摘 | KAREN P Y MARIA T M JOSE L B | 2014 | Food Analytical Methods2014，7，2： | 1 |
| 15 | Environmental policy in a green market显示文摘 | Jose L M Noemi P F | 2002 | Environmental and Resource Economics2002，22，： | 1 |
| 16 | Cd (Ⅱ) complexe with phthalic acid:solution study and crystal structure of cadmium(Ⅱ) phthalate hydrate显示文摘 | JOSE L L V GERARD D MICHELLE P R | 1996 | Canadian Journal of Chemistry1996，74，3： | 1 |
| 17 | Treatment of textile wastewater by heterogeneous Fenton process using a new composite Fe2O3/carbon 显示文摘 | Dantas T L P Mendonca V P Jose H J | 2006 | Chemical Engineering Journal2006，118，5： | 1 |
| 18 | The extraction of an- thocyanins and proanthocyanidins from grapes to wine during fermenta- tive maceration is affected by the enological technique 显示文摘 | NAIARA B V ENCARNA G P JOSE L R | 2011 | J Agr Food Chem2011，59，10： | 1 |
| 19 | Electronic nose based on metal oxide semiconductor sensors and pattern recognition techniques: characterization of vegetable oils显示文摘 | Yolanda G M Concepcion C O Jose L P P | 2001 | Analytica Chimica Acta2001，449，： | 1 |
| 20 | Electronic' nosebased on metal oxide semiconductor sensors and pattern recogni-tion techniques characterization of vegetable oils 显示文摘 | Yolande G M Concepcion C O Jose L P | 2001 | AnalyticalChimica Acta2001，449，12： | 1 |
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