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| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 2 | A strategy for optimizing quality and quantity of DNA extracted from soil显示文摘 | Helmut Bürgmann Manuel Pesaro Franco Widmer Josef Zeyer | 2001 | Journal of Microbiological Methods2001，，1： | 2 |
| 3 | Electrical impedance tomography system based on active electrodes显示文摘 | Pascal O G Andy A Josef B | 2012 | Physiol Meas2012，33，5： | 1 |
| 4 | Effect of covering with natural topsoil as a reclamation measure on brown-coal mining dumpsite 显示文摘 | LUBOS B JOSEF K MARCELA M | 2012 | Journal of Geochemical Exploration2012，113，2： | 1 |
| 5 | Rapid quantification of viable Campylobacter bacteria on chicken carcasses,using real-time PCR and propidium monoazide treatment,as a tool for quantitative risk assessment显示文摘 | JOSEF SEN M H LOFSTROM C HANSEN T B | 2010 | Appl Environ Microbiol2010，76，15： | 1 |
| 6 | Aerodynamic performance analysis of a hypersonic inlet isolator using computa tion and experiment显示文摘 | Brigit U R Carsten D H Josef B | 2003 | Journal of Propulsion and Power2003，19，5： | 1 |
| 7 | Characterization of the last deglacial transition in tropical East Afri显示文摘 | Melissa A B Thomas C J Josef P W | 2014 | Palaeogeography Palaeoclimatology Palaeoecology2014，409，： | 1 |
| 8 | The use of phenology models in plant conservation prograrnmes: the establishment of the earliest cutting date for the wild daffodil Narcissus radiiflorus显示文摘 | Johann B Josef H | 2000 | Biological Conservation2000，93，2： | 1 |
| 9 | Tests for geno- toxicity and mutagenicity of furan and its metabolite cis - 2 - bu- tene - 1,4 - dialin LS178Ytk + / - - mouse lymphoma cells 显示文摘 | Mareo K Andreas B Ingrid R Josef S Werner KL | 2008 | Mutation Research2008，657，： | 1 |
| 10 | Localization of corresponding points in fingerprints by complex fi tering显示文摘 | Kenneth N Josef B | 2003 | Pattern Recognition Letters2003，24，13： | 1 |
| 11 | Dynamic Avalanche in Si Power Diodes and Impact Ionization at the nn : Junction 显示文摘 | B B Martin Domeij Josef Lutz Mikael Ostling | 2000 | Solid State Electronics2000，44，3： | 1 |
| 12 | Modified hysterosalpingography during infertility work-up:use of contrast medium and saline to investigate mechanical factors显示文摘 | Josef S Haim K Joseph B | 2000 | Fertil Steril2000，74，5： | 1 |
| 13 | Diagnosis and management of pathological laughter and crying显示文摘 | Josef Parivizi David B Ciniegas AR | 2006 | Mayo Clin Proc2006，81，11： | 1 |
| 14 | Performance of a cellular hybrid C/TDMA mobile radio system applying joint detection and coherent receiver antenna diversity显示文摘 | JOSEF B ANJA K MARKUS N | 1994 | IEEE Journal on Selected Areas in communications1994，12，4： | 1 |
| 15 | Impacts on electricity consumption of household appliances in Austria: a comparison of time series and cross-section analysis 显示文摘 | REINHARD H PETER B JOSEF Z | 1998 | Energy Policy1998，，26： | 1 |
| 16 | Tunable block co- polymers based on a polysiloxane backbone by anionic ring-opening polymerization 显示文摘 | JOSEF B NICOLA H GUIDO K | 2004 | J Polym Sci Part A: Polym Chem2004，42，16： | 1 |
| 17 | Osteoprotegerin ligand: a regulator of immune responses and bone physiology显示文摘 | Kong Y Y William J B Josef M P | 2000 | Immunology2000，21，10： | 1 |
| 18 | On the substructure of adiabatic shear bands显示文摘 | Josef b Jaroslav Buchar | 1992 | Scripta Met et Mater1992，，27： | 1 |
| 19 | Selenium in Biology: Facts and Medical Perspectives显示文摘 | Josef K?hrle Regina Brigelius-Flohé August B?ck Roland G?rtner Ortwin Meyer Leopold Flohé | 2000 | Biological Chemistry (-)2000，，9： | 1 |
| 20 | Inducible NO synthase and antibacterial host defence in times of Th17/Th22/q'22 immunity显示文摘 | Heiko M Malte B Josef P | 2011 | Cell Microbiology2011，13，3： | 1 |
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