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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Influence of 2-methoxyestradiol on cell mor- phology and Cdc2 Kinase activity in WHC03 esophageal carcino- ma cells显示文摘 | Joubert A Marais S | 2007 | Biomed Res2007，28，1： | 1 |
| 3 | Influence of prostagland in A2 on Bax,Bcl-2 and PCNA expression in MCF-7 cells显示文摘 | Joubert A Bianchi P Maritz C | 2006 | Biomed Res2006，27，4： | 1 |
| 4 | Cure of Fisher rats bearing :adioresistant F98 glioma treated with cis-platinum and irradiated with monochromatic synchrotron X-rays显示文摘 | Biston MC Joubert A Adam JF | 2004 | Cancer Res2004，64，7： | 1 |
| 5 | An investigation of preharvest browning of Litchi peel显示文摘 | Joubert A J Van Lelyveld L J | 1975 | Phytophylactica1975，，7： | 1 |
| 6 | Differential signaling involved in sutherlandia frutescens-induced cell death in mcf-7 and mcf-12a cells显示文摘 | Vorster C Stander A Joubert A | 2012 | J Ethnopharmacol2012，140，1： | 1 |
| 7 | The grapevine polygalacturonase-inhibiting protein ( VvPGIP1 ) reduces Botrytis cinerea susceptibility in transgenic tobacco and differentially inhibits fungal polygalacturonases显示文摘 | Joubert D A Slaughter A R Kemp G | 2006 | Transgenic Res2006，15，： | 1 |
| 8 | C2- and CA-position 17beta-estradiol metabolites and their relation to breast cancer显示文摘 | JOUBERT A VAN Z H LAURENS J | 2009 | Biocell2009，33，3： | 1 |
| 9 | Off center frequency analysis of a complete planar显示文摘 | COETZEE J C JOUBERT J MCNAMARA D A | 2000 | IEEE Transac- tions on Antenna and Propagation2000，48，11： | 1 |
| 10 | The grapevine polygalacturonase-inhibiting protein (VvPGIP1) reduces Botrytis cinerea susceptibility in transgenic tobacco and differentially inhibits fungal polygalacturonases 显示文摘 | Joubert D A Slaughter A R Kemp G | 2006 | Transgenic Research2006，15，6： | 1 |
| 11 | PML absorbing boundary condition for higher-order FDTD schemes显示文摘 | Joubert J | 1997 | Electronics Letters1997，33，3： | 1 |
| 12 | Investigations on HCI contaminated Cu 200 mm wafers using parallel angle resolved XPS 显示文摘 | PELISSIER B BEAURAIN A FONTAINE H DANEL A JOUBERT O | 2009 | Microelectronic Engineering2009，86，： | 1 |
| 13 | Antioxidant activity of South African red and white cuhivar wines: Free radical scavenging 显示文摘 | De Beer D Joubert E Gelderblom W C A | 2003 | Agric Food Chem2003，51，： | 1 |
| 14 | Relative masses of primary feathers显示文摘 | Underhill LG Joubert A | | 0，，： | 1 |
| 15 | 2methoxyestradiol stronglyinhibits human uterine sarcomatous cell growth显示文摘 | Amant F Lottering ML Joubert A | 2003 | Gynecol Oncol2003，91，2： | 1 |
| 16 | 显示文摘 | Joubert J M Latroche M Percheron G A | 1996 | J Alloys Comp1996，240，： | 1 |
| 17 | Compressibility and thermal expansion of LaNi5 and its substitutional derivatives (LaNi5-xMx ; M = Mn, Al, Co) 显示文摘 | Joubert J M Cemy R Latroche M Percheron-Guegan A Yvon K | 2005 | Intermetallics2005，13，： | 1 |
| 18 | A new gadolinium-based contrast agent for magnetic resonance imaging of brain tumors: kinetic study on a C6 rat glioma model显示文摘 | Lahrech H Francois -Joubert A | 2001 | J Magn Reson Imaging2001，14，2： | 1 |
| 19 | Sensitive and specific detection of staphylococcal epidermolysins A and B in broth cultures by flow eytometry-assisted multiplex immunoassay 显示文摘 | Joubert O Keller D Pinek A | 2005 | J Clin Microbiol2005，43，3： | 1 |
| 20 | Roughwall turbulent boundary layers 显示文摘 | PERRY A E SCHEFIELD W M JOUBERT P M | 1969 | Journal of FluidMechanics1969，37，2： | 1 |
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