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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Soil boron fertilization:The role of nutrient sources and rootstocks in citrus production显示文摘Boron(B) is a key element for citrus production, especially in tropical regions, where the nutrient availability is commonly low in the soil. In addition, information about doses, fertilizer sources, methods of application, and particularly, differential nutrient demand of scion/rootstock combinations are required for efficient fertilization of commercial groves. In a non-irrigated sweet orange orchard(cv. Natal), grafted onto Rangpur lime, Swingle citrumelo or Sunki mandarin, we studied the application of two sources of B: boric acid(17% B, soluble in water) and ulexite(12% B, partially soluble in water) at four levels of supply(control without B, and soil application of 2, 4 and 6 kg ha^(-1) yr^(-1) of B). The experiment was carried out for three years(2004-2006). Boron availability in the soil and concentration in the leaves, as well as the fruit yield and quality of trees were evaluated. Soil B extracted with hot water and total leaf B positively correlated with doses of the nutrient applied to the trees. Levels of B in the soil and in the leaves did not vary with fertilizer sources. Fruit yield of trees grafted onto Rangpur lime and Swingle citrumelo was more responsive to B doses than those grafted onto Sunki mandarin. The maximum fruit yield of trees grafted onto Swingle was obtained with 3.2 kg ha^(-1) yr^(-1) of B, and leaf B level of 280 mg kg^(-1) that point out to a highest demand for B when this combination was compared with other rootstocks. Furthermore, fertilization with B did not affect the quality of fruits, but correlated with B and potassium(K) concentrations in the leaves. These results also support that the current recommendations for levels of B in leaves should be revisited. | Dirceu Mattos Jr Franz W R Hippler Rodrigo M Boaretto Eduardo S Stuchi Jose A Quaggio | 2017 | Journal of Integrative Agriculture2017，16，7： | 5 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 5 | Biochemical basis for the in vitro peroxidant action of carbon tetrachloride 显示文摘 | Glende Jr E A Recknagel R O | 1969 | Ex pl Molec Path1969，11，： | 1 |
| 6 | Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes; the insulin resistance atherosclerosis study显示文摘 | Festa A DAgostino R Jr Tracy RP | 2002 | Diabetes2002，51，4： | 1 |
| 7 | Three-dimensional flexibility and stiffness properties of the human thoracic spine 显示文摘 | Panjabi M M Brand R A Jr White A A 3rd | | J Biomech0，1976，： | 1 |
| 8 | Grb2 signaling in cell motility and cancer显示文摘 | Giubellino A Burke T R Jr Bottaro D P | 2008 | Expert Opin Ther Targets2008，12，8： | 1 |
| 9 | Rapid recovery protocol for pefi - operative care of total hip and total hip knee arthroplasty patients 显示文摘 | BEREND K R LOMBARDI A V Jr MALLOPY T H | 2004 | Surg technol Int2004，13，： | 1 |
| 10 | Effect of thickness on the transverse thermalconductivity of thin dielectric films显示文摘 | GRIFFIN Jr A J Brotzen F R | 1994 | J Appl Phys1994，75，8： | 1 |
| 11 | Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS) 显示文摘 | Festa A D'Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 12 | Pentaoxygenated xanthones from Bredemyera floribunda显示文摘 | SILVEIRA E R FALCAL A J C MENEZES Jr A | 1995 | Phytochemistry1995，39，6： | 1 |
| 13 | Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and or paracrine substance显示文摘 | Carrillo-Vieo A Cairo JR Abreu P Lardone PJ Garcia-Maurino S Reiter R J | 2004 | FASEB J2004，18，3： | 1 |
| 14 | An experimental 225 GHz pulsed coherent radar显示文摘 | McMillan R W Trussell C W Jr Bohlander R A | 1991 | IEEE Trans on Microwave Theory and Techniques1991，39，3： | 1 |
| 15 | Chronic subclinical inflammation as part of the insulin-resistance syndrome: the insulin resistance atherosclerosis study (IRAS)显示文摘 | Festa A D Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 16 | Are there trends in hurricane destruction显示文摘 | Pielke R A Jr | 2005 | Nature2005，25，4： | 1 |
| 17 | Time-domain modeling, characterization,and measurements of anechoic and semi-anechoic electromagnetic test chambers显示文摘 | Holloway C L McKenna P M Dalke R A Perala R A and Devor C L Jr | 2002 | Electromagnetic Compatibility IEEE Transactions on2002，44，： | 1 |
| 18 | The Role o{ Risk in Executive Compensation显示文摘 | GRAY S R CANNELLA JR A A | 1997 | Journal of Manage- ment1997，23，4： | 1 |
| 19 | Chronic sub clinical inflammation as part of the insulin resistance syn drome: the insulin resistance atherosclerosis study (IRAS) 显示文摘 | Festa A D'Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 20 | Clinical comparison of the midvastus and medial parapatellar surgical ap- proaches 显示文摘 | WHITE R E Jr ALLMAN J K TRAUGER J A | 1999 | Clin Orthop Relat Res1999，，367： | 1 |
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