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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Plasma cathepsin L:A prognostic marker for pancreatic cancer显示文摘AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic cancer.METHODS:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ELISA.Out of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by immunohistochemistry.Survival of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical analysis.RESULTS:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival analysis.Elevated plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate analysis.The plasma levels of the protease decreased after surgery.Though no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in plasma.CONCLUSION:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease. | Nidhi Singh Prasenjit Das Surabhi Gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta Gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 3 | Efficient construction of multibit tries for IP lookup显示文摘 | Sahni S Kun Suk Kim | 2003 | IEEE/ACM Transactions on Networking2003，11，4： | 2 |
| 4 | GPU - to - GPU and host - to - host mul- tipattern string matching on a GPU 显示文摘 | ZHA X SAHNI S | 2013 | IEEE Transactions on Computers2013，62，6： | 1 |
| 5 | P- complete approximation problems 显示文摘 | Sahni S Gonzalez T | 1976 | Journal of the Association of computing Machinery1976，23，： | 1 |
| 6 | Special issue on general-purpose processing using graphics processing units显示文摘 | GOTTLIED A HWANG K SAHNI S | 2008 | Journal of Parallel and Distributed Computing2008，68，10： | 1 |
| 7 | Flowshop and jobshop schedules:complexity and approximation显示文摘 | GONZALEZ T SAHNI S | 1978 | Operations Research1978，26，1： | 1 |
| 8 | Giant haemangioma of the liver:is enucleation better than resection显示文摘 | SINGH R K KAPOOR S SAHNI P | 2007 | Ann RColl Surg Engl2007，89，5： | 1 |
| 9 | Open shop scheduling to minimize finish time显示文摘 | T Gonsalez S Sahni | 1976 | Journal of ACM1976，23，4： | 1 |
| 10 | Approximation algorithms for sensor deployment显示文摘 | XU Xiaochun SAHNI S | | 0，，12： | 1 |
| 11 | Fibrinogen regulates the expression of inflammatory chemokines through NF- kappaB activation of endothelial cells显示文摘 | Guo M Sahni S K Sahni A | 2004 | Thromb Haem- ost2004，92，4： | 1 |
| 12 | Maximum liftetime broadcasting in wireless networks显示文摘 | PARK J SAHNI S | 2005 | IEEE Transaction on Computers2005，54，9： | 1 |
| 13 | Computing Partitions with Applications to Knapsack Problem显示文摘 | Horowitz E Sahni S | | 0，，02： | 1 |
| 14 | Unusual complications of heroinabuser: transverse myelitis, rhabdomylysis, compartment syndrome, and ARF 显示文摘 | Sahni V Garg D Garg S | 2007 | Clin Toxicol2007，45，10： | 1 |
| 15 | Flow shop and job shop schedules 显示文摘 | Sahni S | 1978 | Operations Research1978，26，： | 1 |
| 16 | Flow shop and job shop schedules 显示文摘 | Gonzalez T Sahni S | 1978 | Operations Research1978，26，： | 1 |
| 17 | 显示文摘 | Srolovitz D J Grest G S Sahni P S | 1984 | Acta Metall1984，32，： | 1 |
| 18 | Efficient 2D multibit tries for packet classification显示文摘 | WENCHENG L SAHNI S | 2009 | IEEE Transactions on Computers2009，58，12： | 1 |
| 19 | Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase 显示文摘 | Jackson SA Sahni S Lee L | 2005 | Bioorg Med Chem2005，13，12： | 1 |
| 20 | Spontaneous correction of the malpositioned percutaneous central venous line in infants显示文摘 | Rastogi S Bhutada A Sahni R | | 0，，09： | 1 |
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