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1螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 2018中华高血压杂志2018,26,3:7
2导致成人与儿童患者30天脑室腹腔分流失败的原因分析(英文)显示文摘OBJECTIVE The aim of this study was to provide a comprehensive benchmark of 30-day ventriculoperitoneal(VP)shunt failure rates for a single institution over a 5-year study period for both adult and pediatric patients,to compare this with the results in previously published literature,and to establish factors associated with shunt failure.METHODS A retrospective database search was undertaken to identify all VP shunt operations performed in a single,regional neurosurgical unit during a 5-year period.Data were collected regarding patient age,sex,origin of hydrocephalus,and whether the shunt was a primary or secondary shunt.Operative notes were used to ascertain the type of valve inserted,which components of the shunt were adjusted/replaced(in revision cases),level of seniority of the most senior surgeon who participated in the operation,and number of surgeons involved in the operation.Where appropriate and where available,postoperative imaging was assessed for grade of shunt placement,using a recognized grading system.Univariate and multivariate models were used to establish factors associated with early(30-day)shunt failure.RESULTS Six hundred eighty-three VP shunt operations were performed,of which 321 were pediatric and 362 were adult.The median duration of postoperative follow-up for nonfailed shunts(excluding deaths)was 1263 days(range 525-2226 days).The pediatric 30-day shunt failure rates in the authors'institution were 8.8%for primary shunts and 23.4%for revisions.In adults,the 30-day shunt failure rates are 17.7%for primary shunts and 25.6%for revisions.In pediatric procedures,the number of surgeons involved in the operating theater was significantly associated with shunt failure rate.In adults,the origin of hydrocephalus was a statistically significant variable.Primary shunts lasted longer than revision shunts,irrespective of patient age.CONCLUSIONS A benchmark of 30-day failures is presented and is consistent with current national databases and previously published data by other groups.The number of surgeons involved in shunt operations and the origin of the patient's hydrocephalus should be described in future studies and should be controlled for in any prospective work.The choice of shunt valve was not a significant predictor of shunt failure.Most previous studies on shunts have concentrated on primary shunts,but the high rate of early shunt failure in revision cases(in both adults and children)is perhaps where future research efforts should be concentrated.Anderson IA Saukila LF Robins JMW Akhunbay-Fudge CY Goodden JR Tyagi AK Phillips N Chumas PD 2018中华神经外科疾病研究杂志2018,17,3:3
3Pritonitis influences mortality in peritoneal dialysis显示文摘Fried LF Bernardinni J Johnston JR 1996J Am Soc Nephrol1996,7,:1
4Detection of trichomonosis in vaginal and urine from women by culture and PCR显示文摘Lawing LF Hedges SR Schwebke JR 2000J Clin Microbiol2000,38,10:1
5Ischemic colitis : an useful clinical diagno- sis, but is it ischemic? 显示文摘Williams LF Jr Wittenberg J 1975Ann Surg1975,182,4:1
6Gene copy number regulates the production of the human chemokine CCL3-L1 显示文摘Townson JR Barcellos LF Nibbs RJ 2002EurJImmunol2002,32,10:1
7Sensitization of U937 leukemia cells to doxorubicin by the MG132proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss显示文摘Ortiz-Lazareno PC Bravo-Cuellar A Lerma-Díaz JM Jave-Suárez LF Aguilar-Lemarroy A Domínguez-Rodríguez JR 2014Cancer Cell Int2014,14,1:1
8Immunotherapy for recurrent miscar- riage 显示文摘Wong LF Porter TF Scott JR 2014Cochrane Database Syst Rev2014,10,00:1
9Snake venom phospholipases A2 : a new class of antitumor agents 显示文摘Rodrigues RS Izidoro LF de Oliveira RJ Jr 2009Protein Pept Lett2009,16,:1
10Pathogenesis of radiation-induced myocardial fibrosis显示文摘Fajardo LF Stewart JR 1973Lab Invest1973,29,2:1
11Image - guided surgical planning using anatomical landmarks in the retrosigmoid approach 显示文摘DA SILVA EB J R LEAL A G MILANO J B DA SILVA LF Jr 2010Acta Neurochir (Wien)2010,152,5:1
12Decline in physical function following hip fracture 显示文摘Marottoli RA Berkman LF Cooney LM Jr 1992J Am Geri- atr Soc1992,40,9:1
13Rapid and sensitive detection of biological warfare agents using time-resolved fluorescence assays 显示文摘Peruski AH Johnson LH 3rd Peruski LF Jr 2002J Immunol Methods2002,263,12:1
14Postprocedural hypo tension after carotid artery stent placement: predictors and short and long term clinical outcomes 显示文摘DangasG Laird JR fr Satler LF 2000Radiology2000,215,:1
15Progression to androgen-independent LNCaP human prostate tumors: cellular and molecular alterations显示文摘Zhou JR Yu L Zerbini LF 2004Int J Cancer2004,110,6:1
16Postprocedural hypotension after carotid artery stent placement: predictors and short-and long-term clinical outcomes 显示文摘Dangas G Laird JR Jr Satler LF 2000Radiology2000,215,3:1
17Immediate TRAM flap breast reconstruction: 128 consecutive cases 显示文摘Elliott LF Eskenazi L Beegle PH Jr 1993Plast Reconstr Surg1993,92,2:1
18Spontaneous cholecystocutaneous fistula a rare complication of gallbladder disease显示文摘Cruz RJ Jr Nahas J de Figueiredo LF 2006Sao Paulo Med J2006,124,:1
19Radiation injury to the beart显示文摘 Fajardo LF Gillette SM 1995Int J Radiao Oncol Bio1 Phys1995,31,:1
20Dramatic improvement in Survival among adult BraZilian AIDS patientS 显示文摘MarinS JR Jamal LF Chen SY 2003AIDS2003,17,:1
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