|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 3 | Thermomechanical cracking due to moving frictional loads显示文摘 | HUANG J H JU F D | 1985 | Wear1985，102，12： | 1 |
| 4 | Modeling and simulation of quenching and tempering process in steels显示文摘 | DENG X H JU D Y | 2013 | Physics Procedia2013，50，： | 1 |
| 5 | Effect of additives on the microstructure of ferrite sintered body and its characteristic evaluation 显示文摘 | SUZUKI Y BI/(N P JU D Y MITAMURA T KOBAYASHI H | 2001 | J Jpn Soc Powder Powder Metallurgy2001，48，： | 1 |
| 6 | Thermal flow simulation on twin rollcasting process for thin strip production of magnesium alloy 显示文摘 | Ju D Y ZHAO H Y HU X D | 2005 | Materials Science Forum2005，，： | 1 |
| 7 | Influence of pressure on coal pyrolysis and char gasification显示文摘 | Yang H P Chen H P Ju F D | 2007 | Energy & Fuels2007，21，6： | 1 |
| 8 | UCP-mediated energy depletionin skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction 显示文摘 | Han D H Nolte L A Ju J S | 2004 | Am J Physiol Endocrinol Metab2004，286，3： | 1 |
| 9 | Adenovirus-mediated intratumoral lymphotactin gene transfer potentiates the antibody-targeted superantigen therapy of cancer显示文摘 | Yu H Zhang L Ju D Pan J Xia D | 2002 | J Mol Med2002，80，9： | 1 |
| 10 | Effect of humidity on the tribological behavior of carbon-carbon composites显示文摘 | Chen J D Chern Lin J H Ju C P | 1996 | Wear1996，193，： | 1 |
| 11 | A rehabilitation robot with force-po- sition hybrid fuzzy controller: hybrid fuzzy control of rehabilitation robot 显示文摘 | Ju M S Lin C C K Lin D H | 2005 | IEEE Transactionjs on Neural Systems and Rehabilitation Engi- neering2005，13，3： | 1 |
| 12 | Vaccination with IL-18 gene-modified, superantigen-coated tumor cells elicits potent antitumor immune response显示文摘 | Yu H Zhang L Ju D Pan J Xia D | 2001 | J Cancer Res Clin Oncol2001，127，12： | 1 |
| 13 | The MMA and SO3Li- grafted polypropylene separator used in Li ion batteries 显示文摘 | Li Z H Ju L Li D C | 2012 | Ionics2012，18，： | 1 |
| 14 | 查看详情显示文摘 | Hao C Yan F Ding L Xue Y D Ju H X | | 0，，06： | 1 |
| 15 | Whole-genome analysis of porcine epidemic diarrhea virus (PEDV) from eastern China 显示文摘 | Yang D Q Ge F F Ju H B | 2014 | Arch Virol2014，19，： | 1 |
| 16 | 查看详情显示文摘 | Ding L Hao C Xue Y D Ju H X | | 0，，： | 1 |
| 17 | 查看详情显示文摘 | Du D Liu S Chen J Ju H Lian H Li J | | 0，，： | 1 |
| 18 | Synthesis of nanosized Co3O4 particles by spray pyrolysis显示文摘 | KIM D Y JU S H KOO H Y | 2006 | Journal of Alloys and Compounds2006，417，12： | 1 |
| 19 | Electrospun Hydrophilic Fumed Silica/Polyacrylonitrile Nanofiber-based Composite Electrolyte Membranes显示文摘 | Jung H Ju D Lee W | 2009 | Electrochimica Acta2009，54，13： | 1 |
| 20 | A rehabilitation robot with force-position hybrid fuzzy controller: hybrid fuzzy control of rehabilitation robot 显示文摘 | M S Ju C C K Lin D H Lin | 2005 | IEEE Transactions on Neural Systems and Rehabilitation Engineering (S1534-4320)2005，13，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员