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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Abnormal placentation:twentyyear analysis显示文摘 | Wu S Kocherginsky M Hibbard JU | 2005 | Am J Obstet Gynecol2005，192，5： | 1 |
| 3 | Regula-tion of growth, fatty acid composition and delta-6 desaturase expression by dietary lipids in gilthead seabream larvae (Sparus aurata) 显示文摘 | Izquierdo M S Robaina L Juárez-Carrillo E | 2008 | Fish Physiol Biochem2008，34，11： | 1 |
| 4 | Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-I induction in astrocytes 显示文摘 | Youn G S Kwon D J Ju S M | 2014 | Toxicol Appl Pharmacol2014，280，1： | 1 |
| 5 | Fast Decoding Algorithm for RS Codes显示文摘 | Ju S M Bi G G | 1997 | IEE Electronics Letters1997，33，17： | 1 |
| 6 | Bilayered scaffold for engineering cellularized blood vessels 显示文摘 | Ju Y M Choi J S Atala A | 2010 | Biomaterials2010，31，15： | 1 |
| 7 | Prevalence and characterisation of potentially virulent Vibrio parahaemolyticus in seafood in Malaysia using conventional methods,PCR and REP-PCR显示文摘 | Paydar M Ju Teh C S Thong K L | 2013 | Food Control2013，32，1： | 1 |
| 8 | Abnormal placentaion: twenty-year analysis 显示文摘 | Wu S Kocherginsky M Hibbard JU | 2005 | Am J Obstet Gynaecol2005，192，： | 1 |
| 9 | Two-mode Operation in Highly Birefringent Photonic Crystal Fiber 显示文摘 | JU J JIN W JDEMOKAN M S | 2004 | IEEE Photon TechnolLett2004，16，11： | 1 |
| 10 | A rehabilitation robot with force-po- sition hybrid fuzzy controller: hybrid fuzzy control of rehabilitation robot 显示文摘 | Ju M S Lin C C K Lin D H | 2005 | IEEE Transactionjs on Neural Systems and Rehabilitation Engi- neering2005，13，3： | 1 |
| 11 | Comparison of phenolic compositions between common and tartary buckwheat (Fagopyrum) sprouts显示文摘 | SUN JU KIM ZAIDUL I S M TATSURO SUZUKI et al | 2008 | Food Chemistry2008，，110： | 1 |
| 12 | Abnormal placentation:twentyyear analysis显示文摘 | Wu S Kocherginsky M Hibbard JU | 2014 | Am J Obstet Gynecol2014，192，5： | 1 |
| 13 | Abnormal placentation: twenty-year analysis显示文摘 | Wu S Kocherginsky M Hibbard JU | 2005 | Am J Obstet Gynecol2005，192，5： | 1 |
| 14 | Establishment and characterization of human uveal maligant melanoma xenografts in nude mice 显示文摘 | Heegaard S Spang-Thomsen M Prause JU | 2003 | Melanoma Research2003，13，3： | 1 |
| 15 | Transforming growth factor induction of vascular endothelial growth factor receptor 1: Mechanism of pericyte-inducted vascular survival in vivo显示文摘 | Shih S Ju M Liu N | 2003 | Proc Nat Acad Sci USA2003，100，15： | 1 |
| 16 | pH/temperature-responsive behaviors of semi-IPN and comb-type graft hydrogels composed of alginate and poly(Nqsopropylacrylamide)显示文摘 | Ju H K Kim S Y Lee Y M | 2001 | Polymer2001，42，16： | 1 |
| 17 | Mitral valve replacement with or without a concomitant Maze procedure in patients with atrial fibril- lation显示文摘 | Kim J B Ju M H Yun S C | 2010 | Heart2010，96，14： | 1 |
| 18 | Investigation of the effects of bottom anti- reflective coating on nanoscale patterns by laser interfer- ence lithography显示文摘 | Park E M Choi J Kang B H Dong K Y Park Y Song I S Ju B K | 2011 | Thin Solid Films2011，519，13： | 1 |
| 19 | A GABAergic system in airway epithelium is essential for mucus overproduction in asthma显示文摘 | Xiang YY Wang S Liu M Hirota JA Li J Ju W | | 0，，07： | 1 |
| 20 | Heat conduction in graphite nanoplatelet-reinforced polymer nanocomposites显示文摘 | Hung M T Choi O Ju Y S | 2006 | Appl Phys Lett2006，89，： | 1 |
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