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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Diagnosis and surgical management of breast cancer metastatic to the spine显示文摘Breast cancer is the most common malignancy and the second leading cause of death in Western women. Breast cancer most commonly metastasizes to the bone and has a particular affinity with the spine, accounting for 2/3 of osseous metastases discovered. With significant improvements in cancer therapies, the number of patients at risk for symptomatic spinal metastases is likely to increase. Patients may suffer from intractable pain and neurological dysfunction, negatively influencing their quality of life. Timely diagnosis of patients is crucial and has been aided by several breakthrough advances in imaging techniques which aid in detection, staging, and follow-up of bone metastases. Breast metastases are usually responsive to hormonal therapy and pharmacologic interventions, but skeletal metastases often require surgical intervention. The treatments are palliative but goals include the preserving or restoring neurologic function, ensuring spinal stability, and relieving pain. Advances in surgical techniques and instrumentation have allowed more effective decompres-sion and stabilization of the spine, and with the support of recent evidence the trend has shifted towards using more advanced surgical options in appropriately selected patients. In this review, the clinical presentation, diagnosis, patient selection, and surgical management of breast cancer metastatic to the spine are discussed. | Derek G Ju Alp Yurter Ziya L Gokaslan Daniel M Sciubba | 2014 | World Journal of Clinical Oncology2014，5，3： | 4 |
| 3 | Epicardium-to-fat transition in injured heart显示文摘 | Qiaozhen Liu Xiuzhen Huang Jin-Hee Oh Ruei-Zeng Lin Shengzhong Duan Ying Yu Rui Yang Ju Qiu Juan M Melero-Martin William T Pu Bin Zhou | 2014 | Cell Research2014，24，11： | 2 |
| 4 | Antiproliferative activity induced by the somatostatin analogue, TT-232, in human pancreatic cancer cells显示文摘 | Lee JU Hosotani R Wada M | 2002 | Eur J Caneer2002，38，11： | 2 |
| 5 | Effective Elastic Moduli of Two-Phase Composites Containing Randomly Dispersed Spherical Inhomogeneities显示文摘 | Chen T M | 1994 | Acta Mechanica1994，103，： | 1 |
| 6 | Enhanced sensor capability of juxtaposed fi-eyclodextrin rings in TiO2 ultrathin matrix as determined by cyclic surface-polarization impedance measurement 显示文摘 | Yang DH Ju M J Maeda A | 2008 | Sensors and Materials2008，20，4： | 1 |
| 7 | Up-regulated CNTF plays a protective role for retrograde degeneration in the axotomized rat retina显示文摘 | Ju WK Kim KY Lee MY Hofmann HD Kirsch M Cha JH | 2000 | Neuroreport2000，11，17： | 1 |
| 8 | Intrafascial nerve-sparing endoscopic extraperitoneal radical prostatectomy 显示文摘 | Stolzenburg JU Rabenalt R Do M | 2008 | Eur Urol2008，53，5： | 1 |
| 9 | The Bmi-1 oncogene induces telomerase activity and immortalizes human mam-mary epithelial cells显示文摘 | Goberdhan PD Jose-Luis M Jacqueline JU | 2002 | Cancer Res2002，62，： | 1 |
| 10 | Thermochemistry of gasphase 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane(b-HMX)显示文摘 | Fan X W Ju X H Xiao H M | 2005 | J Mol Struct(THEOCHEM)2005，714，14： | 1 |
| 11 | Abnormal placentation:twentyyear analysis显示文摘 | Wu S Kocherginsky M Hibbard JU | 2005 | Am J Obstet Gynecol2005，192，5： | 1 |
| 12 | Behind organizational slack and firm performance in China: the moderating roles of owner- ship and competitive intensity显示文摘 | Ju M Zhao H | 1996 | Asia Pacific Journal of Management Journal1996，39，： | 1 |
| 13 | Selective stimulation of VEGFR-1prevents oxygen-induced retinal vascular degeneration in reti-nopathy of prematurity显示文摘 | Shih SC Ju M Liu N Smith LE | 2003 | J Clin Invest2003，112，1： | 1 |
| 14 | Compatibilization of PET/PS Blends Through SMA and PMPI Dual Compatibilizers显示文摘 | Ju M Y Chang F C | 2000 | Poly-mer2000，41，： | 1 |
| 15 | Compatibilization of PET/PS blends through SMA and PMPI dual compatibilizers显示文摘 | Ju M Y Chang F C | 2000 | Polymer2000，41，5： | 1 |
| 16 | Electrochemical performances of electric double layer capacitor with UV-cured gel polymer electrolyte based on poly -poly ( vinylidene fluor- ide) blend显示文摘 | YANG C M JU J B LEE J K | 2004 | Electrochim Acta2004，50，： | 1 |
| 17 | Regula-tion of growth, fatty acid composition and delta-6 desaturase expression by dietary lipids in gilthead seabream larvae (Sparus aurata) 显示文摘 | Izquierdo M S Robaina L Juárez-Carrillo E | 2008 | Fish Physiol Biochem2008，34，11： | 1 |
| 18 | Spatial distribution of carbon sources and sinks in Canada' s forests based on remote sensing显示文摘 | Chen J M Ju W Cihlar J | | 0，，02： | 1 |
| 19 | A cysteine-rich domain of the “mannose” receptor mediates GalNAc-4-SO4 binding显示文摘 | Fiete D J Beranek M C Baenziger JU | 1998 | Proc Natl Acad Sci U S A1998，95，5： | 1 |
| 20 | Incidence of dysphagia after anterior cervical spine surgery: a prospective study显示文摘 | Bazaz R Lee M J Yoo JU | 2002 | Spine2002，27，22： | 1 |
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