4篇
您的检索式：作者名="Ju Xiulian"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CoMFA analysis on a set of new noncompetitive GABA_A receptor antagonists:fipronil and related analogs显示文摘Fipronil and related analogs, a set of new noncompetitive GABAA receptor antagonists, were investigated using comparative molecular field analysis (CoMFA) to explore their three-dimensional quantitative structure-activity relationships (3D-QSAR). Considering the structural complexity of molecules of fipronil and related analogs, three different alignments were performed in this paper. CoMFA model for housefly receptor yield the leave-one-out and cross-validated correlation coefficient q2 value of 0.511 and the conventional correlation coefficient r2 value of 0.997. The new compounds with higher activity would be designed from this model. CoMFA model for rat receptor was not successful using all these three alignments, the reason of which maybe that some molecules adopt different conformations for rat receptor. | HAO Yanli JU Xiulian | 2005 | 计算机与应用化学2005，22，12： | 3 |
| 2 | Investigation of structural requirements for inhibitory activity at the rat and housefly picrotoxinin binding sites in ionotropic GABA receptors using DISCOteeh and CoMFA 显示文摘 | Xiulian Ju Yanli Hao Janfeng Pei | 2007 | Chemosphere2007，69，： | 1 |
| 3 | Cytochrome P450 Monooxygenase Immobilization as a Model of Herbicide Metabolism in vitro显示文摘To investigate herbicide metabolism in vitro by cytochrome P450 with stable enzymatic activity, cytochrome P450 is immobilized in silk fibroin. The enzymatic activity of immobilized cytochrome P450 is maintained above 80% after repeated batch experiments for 10 times. Moreover, the enzymatic activity of immobilized cytochrome P450 is kept as relatively high as 73.8% after storage for two months at 4℃. In addition, immobilization can improve the temperature and pH stability of cytochrome P450. Immobilized cytochrome P450 has the similar affinity Km values for herbicide chlorsulfuron and triasulfuron as the free cytochrome P450. In the case of chlorosulfuron, affinity Km value is 53μmol/L for free cytochrome P450, and 63μmol/L for immobilized cytochrome P450, respectively. In the case of triasulfuron affinity, Km value is 36μmol/L for free cytochrome P450, and 44μmol/L for immobilized cytochrome P450, respectivily. Immobilized cytochrome P450 will be convenient, rapid, stable and continuous for herbicide metabolism in micro-bioreactor in vitro. | 向文胜 Wang Xiangjing Ju Xiulian Ren Tianrui | 2004 | High Technology Letters2004，10，2： | 0 |
| 4 | 依曲韦林的合成路线图解显示文摘依曲韦林(etravirine,1),化学名为4-[[6-氨基-5-溴-2-[(4-氰基苯基)氨基]嘧啶-4-基]-氧基]-3,5-二甲基苄腈,是强生公司下属Tibotec公司开发的新一代非核苷类逆转录酶抑制剂(NNRTIs),2008年1月经美国FDA批准上市,成为高效抗逆转录病毒治疗(HAART)药物的重要组分之一。 | GU Shuangxi XUE Ping ZHU Yuanyuan JU Xiulian Key Lab.for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology School of Chemistry and Environmental Engineering, Wuhan Institute of Technology | 2015 | 中国医药工业杂志2015，46，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员