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| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | Circulating pregnancy as sociated plasma protein a predicts outcome in patients with acute coronary syndromes but no troponin I elevation显示文摘 | Juha M Qiu-Ping Q Tuomo I | 2003 | Circulation2003，108，6： | 1 |
| 3 | Crosstalk between colon cancercells and macrophages via inflammatory mediators and CD47 pro-motes tumour cell migration 显示文摘 | Zhang Y Sime W Juhas M | 2013 | Eur J Cancer2013，49，15： | 1 |
| 4 | Responses of methane oxi-dation to temperature and water content in cover soil of a boreal landfill显示文摘 | JUHA KALLE M EINOLA RIITTA H ETTUNEN JUKKA A | 2007 | Soil Biology & Biochemistry2007，，39： | 1 |
| 5 | Constrained shape modification of cubic B-spline curves by means of knots显示文摘 | JUHA'SZA I HOFFMANNB M | 2004 | Computer-Aided Design2004，36，： | 1 |
| 6 | Microstructural Refinement and Property Enhancement of Cast Light Alloys via Frietion Stir Processing显示文摘 | MA Z Y PILCHAK A L JUHAS M C | 2008 | Scripta Materialia2008，58，5： | 1 |
| 7 | Elevated lev- els of peripheral blood CD14brightCD16+ and CD14dimCD16+ mono- cytes may contribute to the development of retinopathy in patients with juvenile onset type 1 diabetes 显示文摘 | Ryba-Stanis awowska M My liwska J Juhas U | 2015 | Apmis2015，123，9： | 1 |
| 8 | Method for measuring neurotoxicity of aggregating polypeptides with the MTT assay on differentiated neuroblastoma cells 显示文摘 | Datki Z Juha sz A Ga lfi M | 2003 | Brain Res Bull2003，62，3： | 1 |
| 9 | Modelling of chlorophenol treatment in aqueous solutions:ozonation and ozonation combination with UV radiation under acidic conditions显示文摘 | Marjaana H Juha K Rein M | 1998 | Ozone:Science & Engineering1998，20，4： | 1 |
| 10 | Defoliation causes parallel temporal responses in a host tree and its fungal symbionts显示文摘 | Saravesi K Markkola A Rautio P Roitto M Juha Tuomi J | 2008 | Oecologia2008，156，1： | 1 |
| 11 | AMP-activated protein kinase in-hibits NF-κB signaling and inflammation:impact on healthspan andlifespan显示文摘 | Salminen A Juha M Hyttinen T | 2011 | J Mol Med(Berl)2011，89，7： | 1 |
| 12 | Screening for endomtrial cancer in asymptomatic postmenopausal women with conventional and colour Doppler sonography显示文摘 | Jouko P Pirhonen Juha I Mkinen | 1999 | British Journal of Obstetrics and Gynaecology1999，106，1： | 1 |
| 13 | Microstructure Refinement and Property Enhancement of Cast Light Alloys Via Friction Stir Processing 显示文摘 | MA Z Y PILCHAK A L JUHAS M C | 2008 | Scripta Materialia2008，58，5： | 1 |
| 14 | Microstructural refinement and property enhancement of cast light alloys via friction stir processing 显示文摘 | MA Z Y PILCHAK A L JUHAS M C WILLIAMS J C | 2008 | Scripta Materialia2008，58，： | 1 |
| 15 | A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis(APPAC trial)显示文摘 | Hannu Paajanen Juha M Gronroos Tero Rautio | 2013 | BMC Surgery2013，，13： | 1 |
| 16 | Simple semantics in topic deteetion and tracking 显示文摘 | Juha M Helena A M Marko S | 2004 | Information Retrieval2004，7，34： | 1 |
| 17 | Circulating pregnancy-associated plasma protein A predicts outcome in patients with acute coronary syndromes but no troponin I elevation显示文摘 | Juha M Qiu-ping Q Tuomo I | 2003 | Circulation2003，108，： | 1 |
| 18 | Maternal separation at birthand schizophrenia-a long-term follow-up of the Finnish Christ-mas Seal Home Children显示文摘 | Pirjo M Juha V Matti J | 2003 | Schizophr Res2003，60，1： | 1 |
| 19 | Bacillus subtilis and Escherichia eoli essential genes and minimal cell factories after one decade of genome engineering显示文摘 | Juhas M Reuss D Zhu B | 2014 | Microbiology2014，，： | 1 |
| 20 | Tracing the decomposition of dissolved organic carbon in artificial groundwater recharge using carbon isotope ratios显示文摘 | Nina M Kortelainen Juha A Karhu | | 0，，： | 1 |
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