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| 1 | 3D printing of hydrogel composite systems:Recent advances in technology for tissue engineering显示文摘Three-dimensional(3D)printing of hydrogels is now an attractive area of research due to its capability to fabricate intricate,complex and highly customizable scaffold structures that can support cell adhesion and promote cell infiltration for tissue engineering.However,pure hydrogels alone lack the necessary mechanical stability and are too easily degraded to be used as printing ink.To overcome this problem,significant progress has been made in the 3D printing of hydrogel composites with improved mechanical performance and biofunctionality.Herein,we provide a brief overview of existing hydrogel composite 3D printing techniques including laser based-3D printing,nozzle based-3D printing,and inkjet printer based-3D printing systems.Based on the type of additives,we will discuss four main hydrogel composite systems in this review:polymer-or hydrogel-hydrogel composites,particle-reinforced hydrogel composites,fiber-reinforced hydrogel composites,and anisotropic filler-reinforced hydrogel composites.Additionally,several emerging potential applications of hydrogel composites in the field of tissue engineering and their accompanying challenges are discussed in parallel. | Tae-Sik Jang Hyun-Do Jung Houwen Matthew Pan Win Tun Han Shengyang Chen Juha Song | 2018 | International Journal of Bioprinting2018，4，1： | 1 |
| 2 | Customizable design ofmultiple-biomolecule delivery platform for enhanced osteogenic responses via‘tailored assembly system’显示文摘Porous titanium(Ti)scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical properties.However,naturally formed TiO2 on the surface limits fast osseointegration.Different biomolecules have been widely utilized to overcome this issue;however,homogeneous porous Ti scaffolds could not simultaneously deliver multiple biomolecules that have different release behaviors.In this study,functionally graded porous Ti scaffolds(FGPTs)with dense inner and porous outer parts were fabricated using a two-body combination and densification procedure.FGPTs with growth factor(BMP-2)and antibiotics(TCH)exhibited suitable mechanical properties as bone substituting material and presented good structural stability.The release of BMP-2 was considerably prolonged,whereas the release of TCH was comparable to that of homogenous porous titanium scaffolds(control group).The osteogenic differentiation obtained using FGPTs was maintained due to the prolonged release of BMP-2.The antimicrobial properties of these scaffolds were verified using S.aureus in terms of prior release time.In addition,various candidates for graded porous Ti scaffolds with altered pore characteristics were presented. | Hyun Lee Min-Kyu Lee Ginam Han Hyoun-Ee Kim Juha Song Yuhyeon Na Chang-Bun Yoon SeKwon Oh Tae-Sik Jang Hyun-Do Jung | 2022 | Bio-Design and Manufacturing2022，5，3： | 0 |
| 3 | Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages显示文摘Interleukin-10(IL-10)is the most potent anti-inflammatory cytokine in the body and plays an essential role in determining outcomes of many inflammatory diseases.Cellular metabolism is a critical determinant of immune cell function;however,it is currently unclear whether metabolic processes are specifically involved in IL-10 production.In this study,we aimed to find the central metabolic molecule regulating IL-10 production of macrophages,which are the main producers of IL-10.Transcriptomic analysis identified that metabolic changes were predominantly enriched in Kupffer cells at the early inflammatory phase of a mouse endotoxemia model.Among them,pyruvate dehydrogenase kinase(PDK)-dependent acute glycolysis was negatively involved in IL-10 production.Inhibition or knockdown of PDK selectively increased macrophage IL-10 expression.Mechanistically,PDK inhibition increased IL-10 production via profound phosphorylation of adenosine monophosphate(AMP)-activated protein kinase alpha 1(AMPKα1)by restricting glucose uptake in lipopolysaccharide-stimulated macrophages.AMPKα1 consequently activated p38 mitogen-activated protein kinase,c-Jun N-terminal kinase,and cyclic AMP-responsive element-binding protein to regulate IL-10 production.Our study uncovers a previously unknown regulatory mechanism of IL-10 in activated macrophages involving an immunometabolic function of PDK. | Yi Rang Na Daun Jung Juha Song Jong-Wan Park Jung Joo Hong Seung Hyeok Seok | 2020 | Journal of Molecular Cell Biology2020，12，7： | 0 |
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