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| 1 | Pathogenesis and management issues for non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease (NAFLD) has, although it is a very common disorder, only relatively recently gained broader interest among physicians and scientists. Fatty liver has been documented in up to 10 to 15 percent of normal individuals and 70 to 80 percent of obese individuals. Although the pathophysiology of NAFLD is still subject to intensive research, several players and mechanisms have been suggested based on the substantial evidence. Excessive hepatocyte triglyceride accumulation resulting from insulin resistance is the first step in the proposed 'two hit' model of the pathogenesis of NAFLD. Oxidative stress resulting from mitochondrial fatty acids oxidation, NF-κB-dependent inflammatory cytokine expression and adipocytokines are all considered to be the potential factors causing second hits which lead to hepatocyte injury, inflammation and fibrosis. Although it was initially believed that NAFLD is a completely benign disorder, histologic follow-up studies have showed that fibrosis progression occurs in about a third of patients. A small number of patients with NAFLD eventually ends up with end-stage liver disease and even hepatocellular carcinoma. Although liver biopsy is currently the only way to confirm the NAFLD diagnosis and distinguish between fatty liver alone and NASH, no guidelines or firm recommendations can still be made as for when and in whom it is necessary. Increased physical activity, gradual weight reduction and in selected cases bariatric surgery remain the mainstay of NAFLD therapy. Studies with pharmacologic agents are showing promising results, but available data are still insufficient to make specific recommendations; their use therefore remains highly individual. | Marko Duvnjak Ivan Leroti Neven Bari Vedran Tomai Lucija Virovi Juki Vedran Velagi | 2007 | World Journal of Gastroenterology2007，13，34： | 74 |
| 2 | Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)is a condition in which excess fat accumulates in the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic steatosis.The pathogenesis of NAFLD and nonalcoholic steatohepatitis(NASH)has not been fully elucidated.The'two-hit'hypothesis is probably a too simplified model to elaborate complex pathogenetic events occurring in patients with NASH.It should be better regarded as a multiple step process,with accumulation of liver fat being the first step,followed by the development of necroinflammation and fibrosis.Adipose tissue,which has emerged as anendocrine organ with a key role in energy homeostasis,is responsive to both central and peripheral metabolic signals and is itself capable of secreting a number of proteins.These adipocyte-specific or enriched proteins,termed adipokines,have been shown to have a variety of local,peripheral,and central effects.In the current review,we explore the role of adipocytokines and proinflammatory cytokines in the pathogenesis of NAFLD.We particularly focus on adiponectin,leptin and ghrelin,with a brief mention of resistin,visfatin and retinol-binding protein 4 among adipokines,and tumor necrosis factor-α,interleukin(IL)-6,IL-1,and briefly IL-18 among proinflammatory cytokines.We update their role in NAFLD,as elucidated in experimental models and clinical practice. | Sanja Stojsavljevi? Marija Gomer?i? Pal?i? Lucija Virovi? Juki? Lea Smir?i? Duvnjak Marko Duvnjak | 2014 | World Journal of Gastroenterology2014，20，48： | 42 |
| 3 | New experiences with the therapy of acute kidney injury显示文摘 | Kes P Basi'c Juki'c N | 2008 | Prilozi2008，29，： | 1 |
| 4 | Partial Linearization of One Class of the Nonlinear Total Least Squares Problem by Using the Inverse Model Function显示文摘 | D. Juki? R. Scitovski H. Sp?th | 1999 | Computing1999，，2： | 1 |
| 5 | Testing of the retinal visual acuity in high myopia with cataracts显示文摘 | Kordi R Pokupec R Juki T | 2013 | Col Antropo12013，37，4： | 1 |
| 6 | Clinical manifestation of ver- tebrobasilar doliechoectasia显示文摘 | Titlic M Tonkic A Jukie I | 2008 | Bratlslleklisty2008，109，6： | 1 |
| 7 | Partial spectral analysis of hydrological time series显示文摘 | D Juki V Deni-Juki | 2011 | Journal of Hydrology2011，400，12： | 1 |
| 8 | Expression of bone morphoge- netic proteins in kidneys显示文摘 | Cunko VF Kes P Juki 6 NB | 2012 | Acta Med Croatica2012，66，3： | 1 |
| 9 | Expression of bone morphogeneticproteins in kidneys显示文摘 | Cunko VF Kes P Juki NB | | 0，，： | 1 |
| 10 | Clinical manifestations of verte- brobasilar doliehoectasia 显示文摘 | Titlic M Tonkic A Jukie I | 2008 | Bratlsl Lek Listy2008，109，6： | 1 |
| 11 | New experiences with the therapy of acute kidney injury显示文摘 | KES P BASI JUKI N | 2008 | Prilozi2008，29，2： | 1 |
| 12 | Correlation of electronic structure and catalytic activity of Zn-Ni amorphous alloys for the hydrogen evolution reaction显示文摘 | METIKOˇS-HUKOVI′C M JUKI′C A | 2000 | Electrochim Acta2000，45，： | 1 |
| 13 | Impedance spectroscopy of semiconducting films on tin electrodes显示文摘 | M. Metiko?-Hukovi? S. Omanovi? A. Juki? | 1999 | Electrochimica Acta1999，，6： | 1 |
| 14 | 显示文摘 | Mesar I Kes P Juki N B | 2012 | Acta Med Croatica2012，662，： | 1 |
| 15 | Augmenttion of human influenza A rius-specific cytotoxic T lymphocyte memory by influenza vaccine and adjuvanted carriers(ISCOMS)显示文摘 | Francis AE Jhon C Jukie J | 1999 | Virol1999，259，： | 1 |
| 16 | Computed tomographic imaging to determine the frequency of anatomical variations in pneumatization of the ethmoid bone显示文摘 | N. Ba?i? V. Ba?i? T. Juki? M. Ba?i? M. Jeli? J. Hat | 1999 | European Archives of Oto - Rhino - Laryngology1999，，： | 1 |
| 17 | A combined Doppler and morphopathologieal study of ovarian tumors 显示文摘 | Kurjak A Jukie S Kupesic S | 1997 | Ultrasound Obstet Gynecol1997，71，2： | 1 |
| 18 | Cardiovascular diseases after kidney transplantation显示文摘 | Kes P Brunetta B Basi(c)-Juki(c) N | | 0，，7： | 1 |
| 19 | Acute kidney injury in the intensive care unit显示文摘 | Kes P Basi Juki N | 2010 | Bosh J Basic Med Sci2010，10，： | 1 |
| 20 | Wheat dough rheology and bread quality effected by Lacto- bacillus brevis preferment, dry sourdough and lactic acid addition 显示文摘 | Komleni D K Ugari Hardi Juki M | 2010 | International Journal of Food Sci- ence ~ Technology2010，45，7： | 1 |
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