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347篇 您的检索式:作者名="Jun M J"
    题名 作者 年代 出处 被引量
1Advances in immuno-oncology biomarkers for gastroesophageal cancer:programmed death ligand 1,microsatellite instability,and beyond显示文摘Blockade of the programmed death ligand 1(PD-L1) and programmed cell death 1(PD-1) receptor axis represents an effective form of cancer immunotherapy. Preclinical evidence initially suggested that gastric and gastroesophageal junction(GEJ) cancers are potentially immunotherapy-sensitive tumors. Early phase clinical trials have demonstrated promising antitumor activity with PD-1/PD-L1 blockade in advanced or metastatic gastric/GEJ cancer. Microsatellite instability(MSI) and PD-L1 expression have been shown to predict higher response to PD-1 inhibitors as highlighted by the recent approvals of pembrolizumab in treatmentrefractory solid tumors with MSI status and the thirdline or greater treatment of PD-L1 positive advanced gastric/GEJ cancers. However, predictive and prognostic biomarkers remain an ongoing need. In this review, we detail the preclinical evidence and early tissue biomarker analyses illustrating potential predictive biomarkers to PD-1/PD-L1 blockade in gastric/GEJ cancer. We also review the clinical development of PD-1/PD-L1 inhibitors in gastric/GEJ cancer and highlight several areas in need of future investigation in order to optimize the efficacy of PD-1/PD-L1 blockade in gastric/GEJ cancer.Emily M Lin Jun Gong Samuel J Klempner Joseph Chao 2018World Journal of Gastroenterology2018,24,25:10
2如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt 2022英国医学杂志中文版2022,25,6:7
32型糖尿病患者采用血管紧张素转换酶抑制剂治疗后血清肌酐急性升高及其继续治疗对主要临床结局的影响显示文摘血管紧张素转换酶抑制剂开始治疗后血清肌酐急性升高≥30%时推荐停药。但血清肌酐升高后继续服药或停药对主要临床结局的长期影响仍不明确。在ADVANCE(糖尿病与血管疾病行动:培哚普利-吲达帕胺与达美康缓释片对照评估)试验中,11 140例糖尿病患者在6周活性导入期后随机采用培哚普利-吲达帕胺或安慰剂治疗。Ohkuma T Jun M Rodgers A Cooper ME Glasziou P Hamet P Harrap S Mancia G Marre M Neal B Perkovic V Poulter N Williams B Zoungas S Chalmers J Woodward M 赵狄 练桂丽 2019中华高血压杂志2019,27,1:6
4Effects of rare earth elements on microstructure and high temperature mechanical properties of ZC63 alloy 显示文摘Jun J H Kim J M 2005Journal of Materials Science2005,0,910:1
5A new class of doubletalk detectors based on cross-correlation显示文摘Senesty J Dennis R M Jun H C 2000IEEE Trans on Speech and Audio Processing2000,8,2:1
6Selection of microalgae for lipid production under high levels carbon dioxide 显示文摘YOO C JUN S Y LEE J Y AHN C Y OH H M 2010Bioresoure Technology2010,101,1:1
7查看详情显示文摘Kim S D Baek S C Lee Y J Jun K W Kim M J Yoo I S 0,,:1
8The nominal capacity of wireless mesh networks显示文摘Jun J Sichitiu M L 2003IEEE Wireless Communications2003,10,5:1
9Experiments on vision guideddocking of an autonomous underwater vehicle using one cam-era显示文摘Park J Y Jun B H Lee P M 2009Ocean Engineering2009,36,1:1
10Comparing exposure assessment methods for traffic - related air pollution in an adverse pregnancy outcome study 显示文摘WU Jun WILHELM M CHUNG J 2011Environmental Research2011,111,5:1
11DNA Polymerase and Topoisomerase II Inhibitors from Psoralea corylifalia 显示文摘Jun Sun N S H W And J M C 1998Journal of Natural Products1998,61,3:1
12Active diffusers:some prototypes and 2D measurements显示文摘LE Jun xiao AVIS M R COX T J 2005Journal of Sound and Vibration2005,285,12:1
13A Hierarchical Real-Time Control Architecture for a Semi-Autonomous Underwater Vehicle 显示文摘Li J H Jun B H Pan M L 2005Ocean Engineering2005,32,13:1
14Mesenchymal stem cells derived from human adipose tissues favor tumor cell growth in vivo显示文摘Yu J M Jun E S Bae Y C 2008stem Cells Dev2008,17,3:1
15Effects of titanium impurity on alumina surface for the activity of Co/Ti-Al2O3 Fischer-Tropsch catalyst显示文摘PARK S J KIM S M WOO M H BAE J W JUN K W HA K S 2012Appl Catal A: Gen2012,,:1
16Ursolic acid is a PPAR- alpha agonist that regulates hepatic lipid metabolism 显示文摘Jia Y Bhuiyan M J Jun HJ 2011Bioorg Med Chem Lett2011,21,19:1
17Thermal con-ductivity of single-crystalline MgB2显示文摘 Jun J Kazakov S M 2002Phys Rev2002,66,1:1
18Synthesis of thermo-stable high surface area alumina powder from sol-gel derived boehmite 显示文摘Kim S M Lee Y J Jun K W 2007Materials Chemistry and Physics2007,104,56:1
19Nondestructive Evaluation of Austenitic Stainless Steel Using CIC-MFL and LIHa S显示文摘JUN J W CHOI M K LEE J Y 2011IEEE Transactions on Magnetics2011,47,10:1
20Prognostic nomograms for prediction of recurrence and survival after curative liver resection for hepatocellular carcinoma显示文摘Shim JH Jun M J Han S 2015Ann Surg2015,261,5:1
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