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| 1 | Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling显示文摘Triple-negative breast cancer (TNBC) is a heterogeneous disease with a poor prognosis due to the lack of an effective targeted therapy. Histone lysine methyltransferases (KMTs) have emerged as attractive drug targets for cancer therapy. However, the function of the majority of KMTs in TNBC has remained largely unknown. In the current study, we found that KMT nuclear receptor binding SET domain protein 2 (NSD2) is overexpressed in TNBC tumors and that its overexpression is associated with poor survival of TNBC patients. NSD2 regulates TNBC cell survival and invasion and is required for tumorigenesis and tumor growth. Mechanistically, NSD2 directly controls the expression of EGFR and ADAM9, a member of the ADAM (a disintegrin and metalloproteinase) family that mediates the release of growth factors, such as HB-EGF. Through its methylase activity, NSD2 overexpression stimulates EGFR-AKT signaling and promotes TNBC cell resistance to the EGFR inhibitor ge?tinib. Together, our results identify NSD2 as a major epigenetic regulator in TNBC and provide a rationale for targeting NSD2 alone or in combination with EGFR inhibitors as a targeted therapy for TNBC. | Jun-Jian Wang June X. Zou Hong Wang Zhi-Jian Duan Hai-Bin Wang Peng Chen Pei-Qing Liu Jian-Zhen Xu Hong-Wu Chen | 2019 | Acta Pharmacologica Sinica2019，40，8： | 4 |
| 2 | Ferric oxide nanosheet-engineered Mg alloy for synergetic osteosarcoma photothermal/chemodynamic therapy显示文摘Osteosarcoma(OS)is a malignant tumor with a high rate of recurrence.Recently,biodegradable Mg-based implants have become a new therapeutic platform for bone-related diseases.However,poor biosafety and deficient intelligent tumor-killing ability of Mg-based implants are still the main challenges for the pre-cise treatment of OS.Herein,based on the excellent catalytic and photothermal conversion properties of nanozyme ferric oxide(Fe_(3)O_(4)),a novel two-step hydrothermal method for in situ preparation of Fe_(3)O_(4)nanosheets on the surface of plasma electrolytic oxidation(PEO)-treated Mg alloy using Mg-Fe layered double hydroxides(Mg-Fe LDH)as precursor was proposed.Compared with Mg alloy,there were no obvious corrosion cracks on the surface of Fe_(3)O_(4)nanosheets-coated Mg alloy(Fe_(3)O_(4)-NS)immersed in 0.9 wt.%NaCl for 14 days,which demonstrated the corrosion resistance of Mg alloy was significantly enhanced.Cytocompatibility experiments and hemolysis assay confirmed the great biocompatibility of Fe_(3)O_(4)-NS,especially,hemolysis ratio was lower than 1%.Meanwhile,Fe_(3)O_(4)-NS presented excellent cat-alytic oxidation capacity in the presence of H_(2)O_(2),and its temperature can significantly increase from 27℃to approximately 56℃under NIR irradiation.Therefore,intelligent responsive Fe_(3)O_(4)nanosheets-engineered Mg-based implants demonstrated excellent antitumor properties in vivo and in vitro due to their photothermal and chemodynamic synergetic effects.This study provides a novel approach for the preparation of Fe_(3)O_(4)coatings on the surface of Mg alloys and a new strategy for the treatment of OS. | Huihui Du Dongdong Zhang Ru Xu Juning Xie Shiwei Guan Shuhan Chen Feng Peng Shi Qian Xuanyong Liu | 2023 | Journal of Materials Science & Technology2023，，7： | 2 |
| 3 | A high performance electrochemical sensor for acetaminophen based on single-walled carbon nanotube-graphene nanosheet hybrid films显示文摘 | Xu Chen June Zhu Qian Xi | 2012 | Sensors and Actuators B2012，161，： | 1 |
| 4 | A case study of digital-twin-modelling analysis on power-plant-performance optimizations显示文摘China Energy’s National Institute of Clean-and-Low-Carbon Energy(NICE)is developing a Power Plant Smart Management(PPSM)platform that employs digital-twin technology to undertake techno-economic modelling analysis on China Energy’s existing coal-fired power-plant units and explore cost-effective solutions to improve those plant units’thermal efficiencies and operating performance.This paper presents a case study of PPSM on a 320-MWe coal-fired thermal power-plant unit,demonstrating how the digital-twin technology was employed to explore and analyse optimization solutions.Various optimization solutions and their cost-effectiveness were assessed using the digital-twin-modelling analysis;the results indicated the optimization solutions are expected to improve the plant unit’s operating efficiency and reduce its current electricity-generation coal consumption by up to 3.5 g/kWh standard coal equivalent(sce),worth annual fuel-cost savings of approximately 4 million RMB for a single unit or 8 million RMB for the two identical 320-MWe units that the power plant currently operates.The digital twin was also employed to assess the power-plant unit’s operating economics during both summer and winter.In summer,when the unit operates in electricity-generation-only mode,the unit’s operating thermal efficiency could drop by up to 6%points following the grid demand of load changes from 100%maximum continuous rating(MCR)down to 30% MCR,resulting in an~45 RMB/MWh increase of electricity-generation cost.In winter,when the unit operates in combined heat and power(CHP)cogeneration mode,for the same boiler load,the CHP operation increases the plant unit’s operating profit with increasing district-heating duty,although the relative profit gain from the CHP cogeneration could start to decrease when the district-heating steam-extraction flow increases to a certain point that varies depending on the market prices of heat and electricity,while the fuel cost was found to be equivalent to~50% of the unit’s total CHP income cogenerated from its electricity and district heat outputs. | Bin Xu June Wang Xinping Wang Zhihong Liang Liming Cui Xiao Liu Anthony Y.Ku | 2019 | Clean Energy2019，3，3： | 1 |
| 5 | A high performance electrochemical sensor for acetanlinophen based on single-walled carbon nanotube-graphene nanosheet hybrid films显示文摘 | CHEN Xu ZHU June XI Qian | 2012 | Sensors and Actuators B: Chemical2012，161，1： | 1 |
| 6 | Three types of maximally entangled states for a two-particle system显示文摘For a two-particle (spin 1/2) system, three fundamental forms of complete sets of commuting observables (CSCO) composed of two-body operators s 1as 2b are given. The corresponding simultaneous eigenstates constitute three types of maximally entangled states, one of which is the well known Bell basis. This paper discusses the possible pairs of spin observables whose simultaneous measurement outcomes are definitely correlated in probabilistic fashion. | RUAN Manqi, XU Gang & ZENG Jinyan Department of Physics, Tsinghua University, Beijing 100084, China Department of Physics, Peking University, Beijing 100871, China Correspondence should be addressed to Zeng Jinyan (email: jyzeng@pku.edu.cn) Received June 16, 2003 | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，1： | 0 |
| 7 | Past,Present and Future of PXI显示文摘 | Xu Benny Zhu June | 2007 | 国外电子测量技术2007，26，1： | 0 |
| 8 | NUMERICAL STUDY OF SEMI-CONFINED SLOT JET IMPINGEMENT显示文摘The standard k ε turbulence model in conjunction with the logarithmic law of the wall has been applied to the prediction of a fully developed turbulent slot impinging jet within a semi confined space. A single geometry with a Reynolds number of 10,000 and a nozzle to plate spacing of eight slot widths has been considered with inlet boundary conditions based on the previous calculated result of a fully developed turbulent 2 D flow. The numerical results of mean velocity agree with the experimental data. But the fluctuating velocity is somewhat poorly predicted. The difference between the numerical study and the experimental data is attributed directly to the turbulence model, and the application of the wall function. | Xu Jing lei, Xu Zhong, Huang Shu juan Department of Fluid Engineering, Energy and Power School,Xi′an Jiaotong University, Xi′an 710049, P.R.China (Received June 1, 1998) | 1999 | Journal of Hydrodynamics1999，11，3： | 0 |
| 9 | A phase II study on Mefatinib as first-line treatment of patients with advanced non-small-cell lung cancer harboring uncommon EGFR mutations显示文摘Dear Editor,Uncommon mutations in exons 18-21 of the epidermal growth factor receptor(EGFR)gene account for 10%–15%of all EGFR mutations when considered as a whole group[1,2].However,each variant confers heterogeneous clinical outcomes to different generations of EGFR tyrosine kinase inhibitors(TKIs)with G719X,L861Q,and/or S768I showing adequate sensitivity to EGFR inhibition[1–3].Osimertinib,based on its superior survival outcomes,has become the preferred first-line treatment for patients diagnosed with advanced non-small cell lung cancer(NSCLC)harboring common EGFR mutations[4];however,its efficacy in patients harboring G719X,S768I,and/or L861Q mutations was comparable or even inferior to Afatinib[5].Afatinib,a second-generation EGFR-TKI,has received approval for extended clinical indication in treating previously untreated patients with metastatic NSCLC harboring G719X,L861Q,and/or S768I based on the findings from the pooled analysis of three clinical trials(LUX-Lung 2/3/6)[2].The real-world clinical efficacy of Afatinib for treating this patient subset has been consistently demonstrated by two large retrospective studies[6,7].In China,chemotherapy remains a standard first-line treatment for this patient subset,with Afatinib available only as an off-label treatment option. | Pingli Wang Liming Cao Panwen Tian Shengxiang Ren Liyun Miao Chengzhi Zhou Yun Fan Yuping Li Dongqing Lv Xin Zhao Mei Yang Chaonan Zhu Bing Yu June Xu Yong Song Kai Wang | 2023 | Cancer Communications2023，43，9： | 0 |
| 10 | Engineered T Cell Therapies from a Drug Development Viewpoint显示文摘Cancer is one of the leading causes of death worldwide. Recent advances in cellular therapy have demonstrated that this platform has the potential to give patients with certain cancers a second chance at life. Unlike chemical compounds and proteins, cells are living, self-replicating drugs that can be engineered to possess exquisite specificity. For example, T cells can be genetically modified to express chimeric antigen receptors (CARs), endowing them with the capacity to recognize and kill tumor cells and form a memory pool that is ready to strike back against persisting malignant cells. Anti-CD19 chimeric antigen receptor T cells (CART19s) have demonstrated a remarkable degree of clinical efficacy for certain malignancies. The process of developing CART19 essentially follows the conventional “one gene, one drug, one disease” paradigm derived from Paul Ehrlich’s “magic bullet” concept. With major players within the pharmaceutical industry joining forces to commercialize this new category of “living drugs,” it is useful to use CART19 as an example to examine the similarities and differences in its development, compared with that of a conventional drug. In this way, we can assimilate existing knowledge and identify the most effective approach for advancing similar strategies. This article reviews the use of biomarker-based assays to guide the optimization of CAR constructs, preclinical studies, and the evaluation of clinical efficacy;adverse effects (AEs);and CART19 cellular kinetics. Advanced technologies and computational tools that enable the discovery of optimal targets, novel CAR binding domains, and biomarkers predicting clinical response and AEs are also discussed. We believe that the success of CART19 will lead to the development of other engineered T cell therapies in the same manner that the discovery of arsphenamine initiated the era of synthetic pharmaceuticals. | Fang Chen Joseph A. Fraietta Carl H. June Zhongwei Xu J. Joseph Melenhorst Simon F. Lacey | 2019 | Engineering2019，5，1： | 0 |
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