|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antimicrobial peptide LL-37 forms complex with bacterial DNA to facilitate blood translocation of bacterial DNA and aggravate ulcerative colitis显示文摘Bacterial DNA(bacDNA) is frequently found in serum of patient with ulcerative colitis(UC) and Crohn's disease, even blood bacterial culture is negative. How bacDNA evades immune elimination and is translocated into blood remain unclear. Here, we showed that bacDNA avoids elimination and disables bacteriakilling function of antimicrobial peptide LL-37(Cramp in mice) by forming complex with LL-37, which is inducible after culture with bacteria or bacterial products. Elevated LL-37-bacDNA complex was found in plasma and lesions of patients with UC. LL-37-bacDNA promoted inflammation by inducing Th1, Th2 and Th17 differentiation and activating toll-like receptor-9(TLR9). The complex also increased paracellular permeability, which possibly combines its inflammatory effects to promote local damage and bacDNA translocation into blood. Cramp-bacDNA aggravated mouse colitis severity while interference with the complex ameliorated the disease. The study identifies that inflammatogenic bacDNA utilizes LL-37 as a vehicle for blood translocation and to evade immune elimination. Additionally, bacteria may make a milieu by releasing bacDNA to utilize and resist host antimicrobial peptides as a ‘trojan horse'. | Zilei Duan Yaqun Fang Yang Sun Ning Luan Xue Chen Mengrou Chen Yajun Han Yizhu Yin James Mwangi Junkun Niu Kunhua Wang Yinglei Miao Zhiye Zhang Ren Lai | 2018 | Science Bulletin2018，63，20： | 4 |
| 2 | BMAL1 functions as a cAMP-responsive coactivator of HDAC5 to regulate hepatic gluconeogenesis显示文摘 | Jian Li Sihan Lv Xinchen Qiu Jiamin Yu Junkun Jiang Yalan Jin Wenxuan Guo| Ruowei Zhao Zhen-Ning Zhang Chao Zhang Bing Luan | 2018 | Protein & Cell2018，9，11： | 3 |
| 3 | Large-scale multiferroic complex oxide epitaxy with magnetically switched polarization enabled by solution processing显示文摘Complex oxides with tunable structures have many fascinating properties,though high-quality complex oxide epitaxy with precisely controlled composition is still out of reach.Here we have successfully developed solution-based single-crystalline epitaxy for multiferroic(1-x)BiTi(1-y)/2FeyMg(1-y)/2O3–(x)CaTiO3(BTFM–CTO)solid solution in large area,confirming its ferroelectricity at the atomic scale with strong spontaneous polarization.Careful compositional tuning leads to a bulk magnetization of 0.07±0.035μB/Fe at room temperature,enabling magnetically induced polarization switching exhibiting a large magnetoelectric coefficient of 2.7–3.0×10^-7 s/m.This work demonstrates the great potential of solution processing in large-scale complex oxide epitaxy and establishes novel room-temperature magnetoelectric coupling in epitaxial BTFM–CTO film,making it possible to explore a much wider space of composition,phase,and structure that can be easily scaled up for industrial applications. | Cong Liu Feng An Paria S.M.Gharavi Qinwen Lu Junkun Zha Chao Chen Liming Wang Xiaozhi Zhan Zedong Xu Yuan Zhang Ke Qu Junxiang Yao Yun Ou Zhiming Zhao Xiangli Zhong Dongwen Zhang Nagarajan Valanoor Lang Chen Tao Zhu Deyang Chen Xiaofang Zhai Peng Gao Tingting Jia Shuhong Xie Gaokuo Zhong Jiangyu Li | 2020 | National Science Review2020，7，1： | 2 |
| 4 | Impact of the addition of a compound fertilizer on the dissolution of carbonate rock tablets: A column experiment显示文摘 | Song Chao Liu Changli Wang Junkun Zhang Yun Hou Hongbing | 2011 | Applied Geochemistry2011，，： | 1 |
| 5 | Impact of the addition of a compound fertilizer on the dissolution of carbonate rock tablets:A column experiment显示文摘 | Song Chao Liu Changli Wang Junkun | 2011 | Applied Geochemistry2011，26，： | 1 |
| 6 | Impact of the Addition of aCompound Fertilizer on the Dissolution of Carbonate Rock Tablets:aColumn Experiment显示文摘 | Chao S Changli L Junkun W | 2011 | Applied Geochemistry2011，，： | 1 |
| 7 | Trapping mobile targets in wireless sensor networks:an energy-efficient perspective显示文摘 | Jiming Chen Junkun Li T H Lai | 2013 | IEEE Transactions on Vehicular Technology2013，62，7： | 1 |
| 8 | Energy recovery on petro-chemical complexes through heat integration显示文摘 | Feng Xiao Pu Jing Yang Junkun | 2011 | Applied En-ergy2011，88，5： | 1 |
| 9 | Adsorption of arsenite and arsenate within activated alumina grains: equilibrium and kinetics显示文摘 | LIN T F WU Junkun | 2001 | Water Res2001，35，8： | 1 |
| 10 | In-situ quantification of the surface roughness for facile fabrications of atomically smooth thin films显示文摘This work presents an in-situ technique to quantify the layer-by-layer roughness of thin films and heterostructures by measuring the spectral profile of the reflection high-energy electron diffraction(RHEED).The characteristic features of the diffraction spot,including the vertical to lateral size ratio c/b and the asymmetrical ratio c_(1)/c_(2) along the vertical direction,are found to be quantitatively dependent on the surface roughness.The quantitative relationships between them are established and discussed for different incident angles of high-energy electrons.As an example,the surface roughnesses of LaCoO_(3) films grown at different temperatures are obtained using such an in-situ technique,which are confirmed by the ex-situ atomic force microscopy.Moreover,the in-situ measured layer-by-layer roughness oscillations of two LaCoO_(3) films are demonstrated,revealing drastically different information from the intensity oscillations.The experiments assisted with the in-situ technique demonstrate an outstanding high resolution down to-0.1 A.Therefore,the new quantitative RHEED technique with real-time feedbacks significantly escalates the thin film synthesis efficiency,especially for achieving atomically smooth surfaces and interfaces.It opens up new prospects for future generations of thin film growth,such as the artificial intelligence-assisted thin film growth. | Genhao Liang Long Cheng Junkun Zha Hui Cao Jingxian Zhang Qixin Liu Mingrui Bao Jia Liu Xiaofang Zhai | 2022 | Nano Research2022，15，2： | 0 |
| 11 | CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats显示文摘Background and purpose C-C motif chemokine ligand 17(CCL17)presents an important role in immune regulation,which is critical in the pathophysiology of brain injury after subarachnoid haemorrhage(SAH).There is rare evidence to illustrate the function of CCL17 towards SAH.In this study,we try to reveal the therapeutic effects of CCL17 and its underlying mechanism in rat SAH model.Methods SAH rat models were assigned to receive recombinant CCL17(rCCL17)or phosphate buffer saline(PBS).AZD2098 and JR-AB2-011 were applied to investigate the C-C motif chemokine receptor 4(CCR4)/mammalian target of rapamycin complex 2(mTORC2)axis in CCL17-mediated neuroprotection.To elucidate the underlying mechanism,the in vitro kinase assay was performed in primary microglia.Microglial-specific Rictor knockdown was administered via intracerebroventricular injection of adenovirus-associated virus.Brain water content,short-term neurobehavioural evaluation,western blot analysis,quantitative RT-PCR and histological staining were performed.Results The expression of CCL17 was increased and secreted from neurons after oxyhaemoglobin stimulation.Exogenous rCCL17 significantly alleviated neuronal apoptosis,and alleviated short-term neurofunction after SAH in rats.In addition,rCCL17 increased M2-like polarisation of microglia in rats post-SAH and in primary microglia culture.The neuroprotection of rCCL17 was abolished via inhibition of either CCR4 or mTORC2.Conclusion CCL17 activated the CCR4/mTORC2 axis in microglia,which can alleviate SAH-induced neurological deficits by promoting M2-like polarisation of microglia. | Anke Zhang Yibo Liu Houshi Xu Zeyu Zhang Xiaoyu Wang Ling Yuan Cameron Lenahan Chuan Zhang Junkun Jiang Chaoyou Fang Yuanjian Fang Jianmin Zhang Sheng Chen | 2023 | Stroke & Vascular Neurology2023，8，1： | 0 |
| 12 | Early detection of joint degeneration in the subtalar and talonavicular joints secondary to ankle instability in a mouse model显示文摘Background:Many patients with ankle sprain have secondary subtalar and talonavicular injuries,which have a great impact on their life and body.Purpose::This study aimed to investigate the biomechanical impact of ankle instability on the subtalar joint(STJ)and talonavicular joint(TNJ)using a mouse model to enhance the clinical understanding of early stage secondary joint degeneration.Methods:Twenty four 8-week old male C57BL/6 J mice were randomly allocated to three groups.Both the calcaneofibular ligament(CFL)and anterior talofibular ligament(ATFL)of the left ankle were cut off in the CFLþATFL group to simulate severe ankle instability while only the CFL was excised in the CFL group to mimic moderate ankle instability.No operation was done in SHAM group to simulate the normal ankle.Then histological analysis,atomic force microscopy(AFM)–based nanoindentation tests and inspection by scanning electron microscopy(SEM)were used to assess the degree of joint degeneration in the tibiotalar joint(TTJ),STJ and TNJ of three groups.Results:A significant increase of histological score for both CFL and CFLþATFL group was demonstrated in the TTJ,compared with the SHAM group.While in the STJ and TNJ,the histological score only increased for CFLþATFL group.AFM-based nanoindentation results demonstrated significant differences in elastic modulus between all groups in the TTJ,while for the STJ and TNJ,only the comparison between the CFLþATFL group and SHAM group was considered statistically significant.The SEM presented signs of cracking and disintegration within the subchondral bone(SCB)interface in the CFLþATFL group only.Conclusions:The findings indicate that severe ankle instability resulted in early degeneration of the STJ and TNJ in a mouse model,which may provide referential values for clinical practice. | Zhi Chen Ting Liang Junkun Li Chao Gao Fan He Zongping Luo Huilin Yang Hongtao Zhang Jia Yu | 2021 | Medicine in Novel Technology and Devices2021，，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员