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| 1 | Small-Molecule Fluorophores for Near-Infrared IIb Imaging and ImageGuided Therapy of Vascular Diseases显示文摘Accurate and dynamic visualization of vascular diseases can contribute to restraining further deterioration from diseases in a timely manner.However,visualization is still unable to precisely determine whether and to what extent blood vessels or brain tissues are damaged.Here,we report novel benzobis(1,2,5-thiadiazole)-based second near-infrared region(NIR-II)fluorophores HY1-HY4 with highly twisted structures(55°at the S_(0) state),extremely strong aggregation-induced emission(AIE)characteristics(I/I_(0)>13),and remarkably high fluorescence quantum yields(QYs)(up to 14.45%)in the NIR-II region(>1000 nm)and∼0.27%in the nearinfrared IIb window(NIR-IIb,>1500 nm)in aqueous solution.Using NIR-IIb AIE HY4 dots,high-resolution NIR-IIb fluorescence imaging of revascularization and thrombolysis,and real-time feedback of the therapeutic efficacy of Chinese medicine Dengzhan Xixin injection(DXI)on ischemic stroke,were achieved for the first time.In addition,results showed that DXI conferred neuroprotection against cerebral ischemia injury mediated via the angiogenesis pathway.These attractive results provide a new perspective for designing ultrabright NIR-IIb probes for vascular-related phenomena,disease assessment,and precise intraoperative imageguided therapy with a deeper tissue penetration depth and higher resolution. | Yang Li Hua Zhu Xiaobo Wang Yan Cui Lijuan Gu Xiaowen Hou Mengting Guan Junzhu Wu Yuling Xiao Xiaoxing Xiong Xianli Meng Xuechuan Hong | 2022 | CCS Chemistry2022，4，12： | 0 |
| 2 | Physical stimuli-responsive cell-free protein synthesis显示文摘Cell-free protein synthesis has been developed as a critical platform in synthetic biology.Unlike the cell-based synthesis system,cell-free system activates transcriptional and translational mechanisms in vitro,and can control protein synthesis by artificially adding components or chemicals.However,the control method puts forward higher requirements in terms of accurate and non-toxic control,which cannot be achieved by chemical substances.For cell-free system,physical signal is a kind of ideal spatiotemporal control approach to replace chemical substances,realizing high accuracy with little side effect.Here we review the methods of using physical signals to control gene expression in cell-free systems,including studies based on light,temperature,electric field,and magnetic force.The transfer of these switches into cell-free system further expands the flexibility and controllability of the system,thus further expanding the application capability of cell-free systems.Finally,existing problems such as signal source and signal transmission are discussed,and future applications in pharmaceutical production,delivery and industrial production are further looked into. | Junzhu Yang Yuan Lu | 2020 | Synthetic and Systems Biotechnology2020，5，4： | 0 |
| 3 | Effects of Meteorological Factors on Overwintering Ability,Yield and Quality of Forage Rape显示文摘In order to investigate the effects of meteorological factors on rape overwintering ability,forage yield and quality of rape in the North China plain,Brassia campestris L.and Brassica napus L.were used in this study.The results showed that compared with the B.napus L.varieties,the growth period of B.campestris L.was shortened by 10-15 d,the overwintering rate(WR)increased by 50.6%,and the density after winter(PD)increased by 41.5%.The fresh forage yield(FFY)and dry forage yield(DFY)of the B.campestris L.type significantly increased by 40.9%and 38.1%compared with the B.napus L.type.,respectively,while the forage quality of the B.napus L.type rape was significantly better than that of the B.campestris L.type.Compared with the B.campestris L.type,the crude protein(CP),fat,ash and total fatty acid(TFA)contents of the B.napus L.type of rape increased by 27.6%,42.9%,23.9%and 52.3%,respectively,and the milk productivity(HM),relative forage value(RFV)and relative forage quality(RFQ)increased by 14.0%,16.2%and 42.1%,respectively.The light and heat resources before wintering increased the WR and PD(P<0.05),and were positively correlated with FFY and DFY(P>0.05),and lower temperature during the wintering period led to lower WR(P<0.01).The light and heat resources during the overwintering period and after regreening were negatively correlated with FFY and DFY(P>0.05).The contents of CP,fat and TFA of rape had an extremely significant negative correlation with the temperature and sunshine hours before wintering,but an extremely significant positive correlation with the temperature during the wintering period and after regreening,as well as the sunshine hours and rainfall during the wintering period;and HM had an extremely significant positive correlation with the temperature,sunshine hours and rainfall during the wintering period,while RFV and RFQ were only extremely significantly positively correlated with the maximum temperature and rainfall.In summary,in the North China Plain,for autumn sowing rape,the B.campestris L.type can be selected to improve the wintering rate,and the B.napus L.type should be the main choice to improve the forage quality of rape.Therefore,the B.napus L.variety HYZ62 can be selected for autumn sowing in the North China Plain. | Yao ZHANG Junzhu GE Guangsheng ZHOU Xidong WU Yong an YANG Haipeng HOU Qian LIANG Zhiqi MA | 2021 | Agricultural Biotechnology2021，10，3： | 0 |
| 4 | Chemico-biological conversion of carbon dioxide显示文摘The unabated carbon dioxide(CO_(2))emission into the atmosphere has exacerbated global climate change,resulting in extreme weather events,biodiversity loss,and an intensified greenhouse effect.To address these challenges and work toward carbon(C)neutrality and reduced CO_(2)emissions,the capture and utilization of CO_(2)have become imperative in both scientific research and industry.One cutting-edge approach to achieving efficient catalytic performance involves integrating green bioconversion and chemical conversion.This innovative strategy offers several advantages,including environmental friendliness,high efficiency,and multi-selectivity.This study provides a comprehensive review of existing technical routes for carbon sequestration(CS)and introduces two novel CS pathways:the electrochemicalbiological hybrid and artificial photosynthesis systems.It also thoroughly examines the synthesis of valuable Cnproducts from the two CS systems employing different catalysts and biocatalysts.As both systems heavily rely on electron transfer,direct and mediated electron transfer has been discussed and summarized in detail.Additionally,this study explores the conditions suitable for different catalysts and assesses the strengths and weaknesses of biocatalysts.We also explored the biocompatibility of the electrode materials and developed novel materials.These materials were specifically engineered to combine with enzymes or microbial cells to solve the biocompatibility problem,while improving the electron transfer efficiency of both.Furthermore,this review summarizes the relevant systems developed in recent years for manufacturing different products,along with their respective production efficiencies,providing a solid database for development in this direction.The novel chemical-biological combination proposed herein holds great promise for the future conversion of CO_(2)into advanced organic compounds.Additionally,it offers exciting prospects for utilizing CO_(2)in synthesizing a wide range of industrial products.Ultimately,the present study provides a unique perspective for achieving the vital goals of“peak shaving”and C-neutrality,contributing significantly to our collective efforts to combat climate change and its associated challenges. | Liangwei Hu Junzhu Yang Qi Xia Jin Zhang Hongxin Zhao Yuan Lu | 2024 | Journal of Energy Chemistry2024，89，2： | 0 |
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