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| 1 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 2 | <ce:link locator='fx1'/> A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis显示文摘 | Geert D’Haens William J. Sandborn Brian G. Feagan Karel Geboes Stephen B. Hanauer E. Jan Irvine Marc Lémann Philippe Marteau Paul Rutgeerts Jurgen Sch?lmerich Lloyd R. Sutherland | 2007 | Gastroenterology2007，，2： | 2 |
| 3 | Impact of mobile health and medical applications on clinical practice in gastroenterology显示文摘Mobile health apps (MHAs) and medical apps (MAs) are becoming increasinglypopular as digital interventions in a wide range of health-related applications inalmost all sectors of healthcare. The surge in demand for digital medical solutionshas been accelerated by the need for new diagnostic and therapeutic methods inthe current coronavirus disease 2019 pandemic. This also applies to clinicalpractice in gastroenterology, which has, in many respects, undergone a recentdigital transformation with numerous consequences that will impact patients andhealth care professionals in the near future. MHAs and MAs are considered tohave great potential, especially for chronic diseases, as they can support the selfmanagementof patients in many ways. Despite the great potential associated withthe application of MHAs and MAs in gastroenterology and health care in general,there are numerous challenges to be met in the future, including both the ethicaland legal aspects of applying this technology. The aim of this article is to providean overview of the current status of MHA and MA use in the field ofgastroenterology, describe the future perspectives in this field and point out someof the challenges that need to be addressed. | Sven Kernebeck Theresa S Busse Maximilian D Bottcher Jurgen Weitz Jan Ehlers Ulrich Bork Didactics Educational Research in Health | 2020 | World Journal of Gastroenterology2020，26，29： | 2 |
| 4 | <ce:link locator='fx1'/> A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis显示文摘 | Geert D'Haens William J. Sandborn Brian G. Feagan Karel Geboes Stephen B. Hanauer E. Jan Irvine Marc Lémann Philippe Marteau Paul Rutgeerts Jurgen Sch?lmerich Lloyd R. Sutherland | 2007 | Gastroenterology2007，，2： | 2 |
| 5 | Golimumab administered subcutaneously every 4 weeks in ankylosing spondy- litis: 104-week results of the GO-RAISE study显示文摘 | Jurgen Braun Atul Deodhar Robert D Inman | 2012 | Ann Rheum Dis2012，71，5： | 1 |
| 6 | Bcl9/Bcl91 are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas显示文摘 | JURGEN D NORBERT W PASCALE A | 2010 | Cancer Research2010，70，16： | 1 |
| 7 | Efflux-dependent auxin gradients establish the apical-basal axis of Arabidopsis 显示文摘 | Friml J Vieten A Sauer M Weijers D Schwarz H Hamann T Offringa R Jurgens G | 2003 | Nature2003，426，： | 1 |
| 8 | Unspecific binding of group B streptocococcal cocytdysin (CAMP factor) to immunoglobulins and its possible in pathogenicity显示文摘 | Jurgens D Sterzik B Fehrenbeeh F J | 1987 | J Exp Med1987，165，3： | 1 |
| 9 | Auxin and embryo axis formation:the ends in sight?显示文摘 | Weijers D Jurgens G | 2005 | Current Opinion in Plant Biol2005，8，： | 1 |
| 10 | The effect of dietary active dry yeast supplement on performance of sows during gestation-lactation and their pigs显示文摘 | JURGENS M H RIKABI R A ZIMMERMAN D R | 1997 | Journal of Animal Science1997，75，： | 1 |
| 11 | High-resolution 1D moire s as counterfeit security features显示文摘A moireis an interference pattern that appears when two different periodic structures are overlaid.The image created is extremely sensitive to small variations in the original layers and is thus very interesting for anti-counterfeit protection.We present a microfabricated 1D moire enabling complex high-resolution patterns as a significantly improved security feature that cannot be reproduced using standard printing methods.Furthermore,we demonstrate,theoretically and experimentally,that a microscopic deviation from the original design results in a macroscopic variation in the moire that is clearly visible to the naked eye.The record resolution achieved in the elements fabricated and the increased design freedom,make these high-resolution moires excellent candidates for a variety of visually appealing security applications. | Victor J Cadarso Sylvain Chosson Katrin Sidler Roger D Hersch Jurgen Brugger | 2013 | Light(Science & Applications)2013，2，1： | 1 |
| 12 | The potential for estradiol and ethinylestradiol degradation in English rivers显示文摘 | Jurgens M D Holthaus K I E Johnson A C | 2002 | Environ Toxicol Chem2002，21，： | 1 |
| 13 | Unspe- cific binding of group B streptococcal coeytdysin ( CAMP factor) to immunoglobulins and its possible role in patho- genicity 显示文摘 | JURGENS D STERZIK B FEHRENBEEH F J | 1987 | J Exp Med1987，165，3： | 1 |
| 14 | The effect of dietary active dry yeast supplement on performance of sows during gestation lactation and their pigs显示文摘 | Jurgens M H Rikabi R A Zimmerman D R | 1997 | J Anim Sci1997，75，3： | 1 |
| 15 | A retrospective analysis of 42 patients 显示文摘 | Jurgens H Bier V Harms D Malign<1nl peripheral neuro-ectodermal tumors | 1988 | Cancer1988，61，2： | 1 |
| 16 | The effects of vapreotide, a somatostatin analogue, on gastric acidity, gallbladder emptying and hormone release after 1 week of continuous subcutaneous infusion in normal subjects显示文摘 | MARC A R JURGEN D ANNETTE Z | 1999 | Brit J Clin Pharmacol1999，47，： | 1 |
| 17 | Receptor-like kinases shape the plant 显示文摘 | SMET I D VOSS U JURGENS G | 2009 | Nat Cell B iol2009，11，10： | 1 |
| 18 | Strategies of adaptatior1 of oxygen transport systems in mammals to life at high altitude显示文摘 | Jurgens K D | | 0，，09： | 1 |
| 19 | Malignant peripheral neuroectodermal tumors: a retrospective analysis of 42 patients 显示文摘 | Jurgens H Bier V Harms D | 1988 | Cancer1988，61，2： | 1 |
| 20 | Stem cells that make stems显示文摘 | WEIGEL D JURGENS G | 2002 | Nature2002，415，6873： | 1 |
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