|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | SYFPEITHI: database for MHC ligands and peptide motifs显示文摘 | Hans-Georg R Jutta B Oskar AB | 1999 | Immunogenetics1999，50，： | 2 |
| 2 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 3 | Sorption of tetracycline and chlortetracycline on K-and Ca-Saturated soil clays, humic substances, and Clay-Humic complexes 显示文摘 | Jutta R V P David A L | 2007 | Environ Sci Technol2007，41，： | 1 |
| 4 | Mature embryo axis-based high frequency somatic embryogenesis and plant regeneration from mult-iple cultivars of barley显示文摘 | SHARMA VIJENDRA K MENDEL RALF R JUTTA SCHULZE | 2005 | Journal of Experimental Botany2005，，7： | 1 |
| 5 | Effect of the novel anxiolytic drug deramciclane on cytochrome P450 2D6 activity as measured by desipramine pharmacokinetics显示文摘 | Kari L Steven DB Harry B Juha R Jutta H Harry S | 2004 | Eur J Clin Pharmacol2004，59，： | 1 |
| 6 | Newmiero RNAs from mouse and human 显示文摘 | Mariana LQ Reinhard R Jutta M | 2003 | Rna2003，9，： | 1 |
| 7 | Does health information matter for modifying consumption?a field experi-ment measuring the impact of risk information on fish con-sumption显示文摘 | JuTTA R STEPHAN M SANDRINE B et aL | 2009 | Review of Agricultural Economics2009，31，1： | 1 |
| 8 | Coexpression of Avian Influenza Virus H5 and N1 by Recombinant Newcastle disease virus and the impact on immune response in chickens显示文摘 | Kristina R Jutta V Daniela D | 2011 | Avi- an Diseases2011，55，3： | 1 |
| 9 | Parallel bubble columns with fed-batch technique for microbial process development on a small scale显示文摘 | Jutta A R Christina N Matthias A | 1999 | Chem Eng Technol1999，22，12： | 1 |
| 10 | 鹅源新城疫病毒ZJI株基因组cDNA克隆的序列修饰显示文摘将鹅源新城疫病毒ZJI株全基因组cDNA克隆通过酶切切下包含T7启动子区域和转录载体的片段,将其自身环化后获得约6.5kb的质粒。设计引物,利用基因定点突变技术,在此质粒上T7启动子与NDV Leader序列之间突变插入额外的3个G碱基,将此突变最终引入到原基因组cDNA克隆中。应用RT-PCR技术从尿囊液中扩增NDV基因组F/HN基因区域部分片段,利用限制性内切酶BsmB I将扩增片段连接,最终将原cDNA克隆中相应片段替换下。测序结果表明,原基因组cDNA克隆中特定位置碱基插入突变成功,F/HN基因区域碱基突变均得以纠正。以上cDNA克隆的修饰与替换为该毒株的反向遗传研究打下了基础。 | 刘玉良 胡顺林 张艳梅 吴艳涛 刘秀梵 Rmer-Oberdrfer Angela Weits Jutta Lange Martina 黄勇 龙进学 | 2005 | 微生物学通报2005，32，6： | 1 |
| 11 | Health Information and Substitution between fish: Lessons From Laboratory and Field Experiments 显示文摘 | Stephan M Jutta R Sandrine B | 2008 | Food Policy2008，33，3： | 1 |
| 12 | High viable cell concentration fed-batch culture of hybridoma cells through on-line nutrient feeding 显示文摘 | Zhou W C Jutta R Hu W S | 1995 | Biotechnol Bioeng1995，46，6： | 1 |
| 13 | Amphiphilic poly (ethylene oxide ) macromolecular RAFT agent as a stabilizer and control agent in ab initio batch emulsion polymerization 显示文摘 | Jutta R Francois S Chuong B | 2008 | Macromolecules2008，41，12： | 1 |
| 14 | Modelling vertical migration of the cyanobacterium Microcystis 显示文摘 | Petra M V Jutta P Luuc R M | 1997 | Hydrobiologia1997，349，： | 1 |
| 15 | Parallel bubble columns with fed-batch technique for microbial process development on a small scale显示文摘 | Jutta A R Christina N Matthias A | 1999 | Chem Eng Technol1999，22，12： | 1 |
| 16 | Parallel substrate feeding and pH-control in shaking-flasks显示文摘 | Dirk W B Jutta A R Christina N | 2001 | Biochem Eng J2001，7，： | 1 |
| 17 | Determination of BOD values of starch-containing waste water by a BOD-biosensor 显示文摘 | MONIKA R ANDREAS H JUTTA M | 1998 | Biosensors and Bioelectronics1998，13，10： | 1 |
| 18 | Leadership and the provision of fe food显示文摘 | Hennessy David A Jutta R | 2001 | American Journal of Agricultural Ecunornies2001，183，4： | 1 |
| 19 | A new class of organosilanemodified polycarboxylate superplasticizers with low sulfate sensitivity显示文摘 | Wei F Francois S Jutta R | 2012 | Cement and Concrete Research2012，42，1： | 1 |
| 20 | Level of protection of chickens against highly pathogenic H5 avian influenza virus with Newcastle disease virus based live attenuated vector vaccine depends on homology of H5 sequence between vaccine and challenge virus显示文摘 | Angela R O Jutta V Dorothee H | 2008 | Vaccine2008，26，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员